FOXB1_XENLA
ID FOXB1_XENLA Reviewed; 319 AA.
AC O93529;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Forkhead box protein B1;
DE Short=FoxB1;
DE AltName: Full=Transcription factor FKH-5;
GN Name=foxb1 {ECO:0000303|PubMed:15656969};
GN Synonyms=fkh5 {ECO:0000303|PubMed:11404077};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAC62623.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL
RP STAGE, AND INDUCTION.
RC TISSUE=Ectoderm {ECO:0000269|PubMed:11404077}, and
RC Gastrula {ECO:0000269|PubMed:11404077};
RX PubMed=11404077; DOI=10.1016/s0925-4773(01)00358-6;
RA Gamse J.T., Sive H.;
RT "Early anteroposterior division of the presumptive neurectoderm in
RT Xenopus.";
RL Mech. Dev. 104:21-36(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP REVIEW.
RX PubMed=15656969; DOI=10.1016/j.gene.2004.09.037;
RA Pohl B.S., Knoechel W.;
RT "Of fox and frogs: fox (fork head/winged helix) transcription factors in
RT Xenopus development.";
RL Gene 344:21-32(2005).
CC -!- FUNCTION: Probable transcription factor. May be involved in the early
CC anteroposterior patterning of the neuroectoderm.
CC {ECO:0000269|PubMed:11404077, ECO:0000269|PubMed:15656969}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC -!- TISSUE SPECIFICITY: In early gastrulae, expressed in the inner layer of
CC the posterior dorsal ectoderm and in non-involuted mesoderm. By the
CC mid-gastrula stage, expressed solely in the posterior ectoderm. At the
CC end of gastrulation, expressed in ectodermal regions fated to become
CC diencephalon, midbrain and hindbrain, and weakly expressed in regions
CC fated to become spinal cord and tailbud. At the neurula stage,
CC expressed in the midbrain and posterior forebrain (diencephalon) but
CC not in the more anterior forebrain (telencephalon). Also expressed
CC posteriorly in rhombomere 5. At tailbud stages, expression remains in
CC the anterior brain and is also detectable along the length of the
CC central nervous system and in the tailbud.
CC {ECO:0000269|PubMed:11404077}.
CC -!- DEVELOPMENTAL STAGE: Expression begins in early gastrula stage embryos,
CC peaks at the mid-gastrula stage and remains detectable until late
CC tailbud. {ECO:0000269|PubMed:11404077}.
CC -!- INDUCTION: By FGF signaling. {ECO:0000269|PubMed:11404077}.
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DR EMBL; AF064810; AAC62623.1; -; mRNA.
DR EMBL; BC124883; AAI24884.1; -; mRNA.
DR RefSeq; NP_001081836.1; NM_001088367.1.
DR AlphaFoldDB; O93529; -.
DR SMR; O93529; -.
DR GeneID; 398078; -.
DR KEGG; xla:398078; -.
DR CTD; 398078; -.
DR Xenbase; XB-GENE-1018260; foxb1.S.
DR OMA; HMYSSSM; -.
DR OrthoDB; 1236900at2759; -.
DR Proteomes; UP000186698; Chromosome 3S.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; NAS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0007412; P:axon target recognition; ISS:UniProtKB.
DR GO; GO:0061381; P:cell migration in diencephalon; ISS:UniProtKB.
DR GO; GO:0007398; P:ectoderm development; IEP:UniProtKB.
DR GO; GO:0033504; P:floor plate development; ISS:UniProtKB.
DR GO; GO:0021855; P:hypothalamus cell migration; ISS:UniProtKB.
DR GO; GO:0061379; P:inferior colliculus development; ISS:UniProtKB.
DR GO; GO:0021767; P:mammillary body development; ISS:UniProtKB.
DR GO; GO:0061374; P:mammillothalamic axonal tract development; ISS:UniProtKB.
DR GO; GO:0030901; P:midbrain development; ISS:UniProtKB.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.
DR GO; GO:0022008; P:neurogenesis; IEP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR GO; GO:0001756; P:somitogenesis; ISS:UniProtKB.
DR GO; GO:0022029; P:telencephalon cell migration; ISS:UniProtKB.
DR GO; GO:0008542; P:visual learning; ISS:UniProtKB.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..319
FT /note="Forkhead box protein B1"
FT /id="PRO_0000257998"
FT DNA_BIND 13..107
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 278..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 319 AA; 34954 MW; 80F3ACD975929D86 CRC64;
MPRPGRNTYS DQKPPYSYIS LTAMAIQGSQ EKMLPLSEIY KFIMDRFPYY RENTQRWQNS
LRHNLSFNDC FIKIPRRPDQ PGKGSFWALH PRCGDMFENG SFLRRRKRFK VMKSDHLAPS
KASDAAQYLQ QQAKLRLSAL AASGTHLPPM STYNLGVSPT SSFKHPFAIE NIIAREYKMP
GGLAFSTMQP MPAAYPLHNQ LTTVGGSIGT GWPHMYSSSM LDSTTPISMA NSDYSVSAYG
VPIKPICHGA QTLLPAIPVP IKPTAALPAL PTHIPAILSN SSPSMSPTSP QTATSQSSPA
TPSDTLTNPS TALLSVAVH
