ID   FOXB2_HUMAN             Reviewed;         432 AA.
AC   Q5VYV0;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Forkhead box protein B2;
GN   Name=FOXB2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
CC   -!- FUNCTION: Transcription factor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; AL353637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS35045.1; -.
DR   RefSeq; NP_001013757.1; NM_001013735.1.
DR   AlphaFoldDB; Q5VYV0; -.
DR   SMR; Q5VYV0; -.
DR   STRING; 9606.ENSP00000365898; -.
DR   iPTMnet; Q5VYV0; -.
DR   PhosphoSitePlus; Q5VYV0; -.
DR   BioMuta; FOXB2; -.
DR   DMDM; 74747718; -.
DR   EPD; Q5VYV0; -.
DR   MassIVE; Q5VYV0; -.
DR   PaxDb; Q5VYV0; -.
DR   PeptideAtlas; Q5VYV0; -.
DR   PRIDE; Q5VYV0; -.
DR   Antibodypedia; 12836; 175 antibodies from 27 providers.
DR   DNASU; 442425; -.
DR   Ensembl; ENST00000376708.1; ENSP00000365898.1; ENSG00000204612.1.
DR   GeneID; 442425; -.
DR   KEGG; hsa:442425; -.
DR   MANE-Select; ENST00000376708.1; ENSP00000365898.1; NM_001013735.1; NP_001013757.1.
DR   UCSC; uc004ako.1; human.
DR   CTD; 442425; -.
DR   DisGeNET; 442425; -.
DR   GeneCards; FOXB2; -.
DR   HGNC; HGNC:23315; FOXB2.
DR   HPA; ENSG00000204612; Tissue enriched (brain).
DR   neXtProt; NX_Q5VYV0; -.
DR   OpenTargets; ENSG00000204612; -.
DR   PharmGKB; PA145148830; -.
DR   VEuPathDB; HostDB:ENSG00000204612; -.
DR   eggNOG; KOG3562; Eukaryota.
DR   GeneTree; ENSGT00940000161970; -.
DR   HOGENOM; CLU_040357_2_1_1; -.
DR   InParanoid; Q5VYV0; -.
DR   OMA; SGGFKHP; -.
DR   OrthoDB; 1236900at2759; -.
DR   PhylomeDB; Q5VYV0; -.
DR   TreeFam; TF316127; -.
DR   PathwayCommons; Q5VYV0; -.
DR   SignaLink; Q5VYV0; -.
DR   BioGRID-ORCS; 442425; 12 hits in 1092 CRISPR screens.
DR   GenomeRNAi; 442425; -.
DR   Pharos; Q5VYV0; Tdark.
DR   PRO; PR:Q5VYV0; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q5VYV0; protein.
DR   Bgee; ENSG00000204612; Expressed in sural nerve and 7 other tissues.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   4: Predicted;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..432
FT                   /note="Forkhead box protein B2"
FT                   /id="PRO_0000263091"
FT   DNA_BIND        13..107
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          118..220
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          413..432
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        135..163
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        164..209
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   432 AA;  45581 MW;  9A832ACDD9A765EF CRC64;
     MPRPGKSSYS DQKPPYSYIS LTAMAIQHSA EKMLPLSDIY KFIMERFPYY REHTQRWQNS
     LRHNLSFNDC FIKIPRRPDQ PGKGSFWALH PDCGDMFENG SFLRRRKRFK VLRADHTHLH
     AGSTKSAPGA GPGGHLHPHH HHHPHHHHHH HAAAHHHHHH HPPQPPPPPP PPPPHMVHYF
     HQQPPTAPQP PPHLPSQPPQ QPPQQSQPQQ PSHPGKMQEA AAVAAAAAAA AAAAVGSVGR
     LSQFPPYGLG SAAAAAAAAA ASTSGFKHPF AIENIIGRDY KGVLQAGGLP LASVMHHLGY
     PVPGQLGNVV SSVWPHVGVM DSVAAAAAAA AAAGVPVGPE YGAFGVPVKS LCHSASQSLP
     AMPVPIKPTP ALPPVSALQP GLTVPAASQQ PPAPSTVCSA AAASPVASLL EPTAPTSAES
     KGGSLHSVLV HS