ID   FOXB2_MOUSE             Reviewed;         428 AA.
AC   Q64733;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 148.
DE   RecName: Full=Forkhead box protein B2;
DE   AltName: Full=Transcription factor FKH-4;
GN   Name=Foxb2; Synonyms=Fkh4;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8861101; DOI=10.1016/0925-4773(96)00507-2;
RA   Kaestner K.H., Schuetz G., Monaghan A.P.;
RT   "Expression of the winged helix genes fkh-4 and fkh-5 defines domains in
RT   the central nervous system.";
RL   Mech. Dev. 55:221-230(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4-114, AND DEVELOPMENTAL STAGE.
RC   STRAIN=129;
RX   PubMed=7689224; DOI=10.1073/pnas.90.16.7628;
RA   Kaestner K.H., Lee K.H., Schloendorff J., Hiemisch H., Monaghan A.P.,
RA   Schuetz G.;
RT   "Six members of the mouse forkhead gene family are developmentally
RT   regulated.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:7628-7631(1993).
CC   -!- FUNCTION: Transcription factor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Expressed during embryogenesis.
CC       {ECO:0000269|PubMed:7689224}.
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DR   EMBL; X92591; CAA63335.1; -; mRNA.
DR   EMBL; X71942; CAA50744.1; -; Genomic_DNA.
DR   CCDS; CCDS29686.1; -.
DR   PIR; D47746; D47746.
DR   RefSeq; NP_032049.1; NM_008023.1.
DR   AlphaFoldDB; Q64733; -.
DR   SMR; Q64733; -.
DR   STRING; 10090.ENSMUSP00000072687; -.
DR   PhosphoSitePlus; Q64733; -.
DR   PaxDb; Q64733; -.
DR   PRIDE; Q64733; -.
DR   Antibodypedia; 12836; 175 antibodies from 27 providers.
DR   DNASU; 14240; -.
DR   Ensembl; ENSMUST00000072915; ENSMUSP00000072687; ENSMUSG00000056829.
DR   GeneID; 14240; -.
DR   KEGG; mmu:14240; -.
DR   UCSC; uc008gxc.1; mouse.
DR   CTD; 442425; -.
DR   MGI; MGI:1347468; Foxb2.
DR   VEuPathDB; HostDB:ENSMUSG00000056829; -.
DR   eggNOG; KOG3562; Eukaryota.
DR   GeneTree; ENSGT00940000161970; -.
DR   HOGENOM; CLU_040357_2_1_1; -.
DR   InParanoid; Q64733; -.
DR   OMA; SGGFKHP; -.
DR   OrthoDB; 1236900at2759; -.
DR   PhylomeDB; Q64733; -.
DR   TreeFam; TF316127; -.
DR   BioGRID-ORCS; 14240; 1 hit in 72 CRISPR screens.
DR   PRO; PR:Q64733; -.
DR   Proteomes; UP000000589; Chromosome 19.
DR   RNAct; Q64733; protein.
DR   Bgee; ENSMUSG00000056829; Expressed in strand of hair and 34 other tissues.
DR   ExpressionAtlas; Q64733; baseline and differential.
DR   Genevisible; Q64733; MM.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..428
FT                   /note="Forkhead box protein B2"
FT                   /id="PRO_0000091805"
FT   DNA_BIND        12..103
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          118..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          408..428
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        136..164
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        165..206
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   428 AA;  45170 MW;  DB8A8EFD1E94AB10 CRC64;
     MPRPGKSSYS DQKPPYSYIS LTAMAIQHSA EKMLPLSDIY KFIMERFPYY REHTQRWQNS
     LRHNLSFNDC FIKIPRRPDQ PGKGSFWALH PDCGDMFENG SFLRRRKRFK VLRADHAHLH
     SGSSKGAPGT GPGGHLHPHH PHHAHHHHHH HHHAAHHHHH HHPPQPPPPP PPHMVPYFHQ
     QPAPAPQPPH LPSQPAQQPQ PQSQPPQTSH PGKMQEAAAV AAAAAAAAAA AVGSVGRLSQ
     FPPYGLGSAA AAAAAAAAST TGFKHPFAIE NIIGRDYKGV LQAGGLPLAS VMHHLGYPVP
     GQLSNVVGSV WPHVGVMDSV AAAAAAAAAA GVPVGPEYGA FGVPVKALCH SANQSLPAVP
     VPIKPTPALP PVTTLPPALS VPTASQQLPA PSTVCAAAAS PTAPLLEPTA AGRADSKGSS
     LHSVLVHS