ID   FOXB2_XENLA             Reviewed;         317 AA.
AC   Q8JIT6;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Forkhead box protein B2;
DE            Short=FoxB2;
DE            Short=xFoxB2;
DE   AltName: Full=Fork head domain-related protein 5;
DE            Short=FD-5;
DE            Short=xFD-5;
GN   Name=foxb2 {ECO:0000312|EMBL:CAD31848.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:CAD31848.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP   STAGE.
RX   PubMed=12204271; DOI=10.1016/s0925-4773(02)00184-3;
RA   Pohl B.S., Knoechel S., Dillinger K., Knoechel W.;
RT   "Sequence and expression of FoxB2 (XFD-5) and FoxI1c (XFD-10) in Xenopus
RT   embryogenesis.";
RL   Mech. Dev. 117:283-287(2002).
RN   [2] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4-114.
RX   PubMed=1358174; DOI=10.1016/0925-4773(92)90007-7;
RA   Knoechel S., Lef J., Clement J.H., Klocke B., Hille S., Koester M.,
RA   Knoechel W.;
RT   "Activin A induced expression of a fork head related gene in posterior
RT   chordamesoderm (notochord) of Xenopus laevis embryos.";
RL   Mech. Dev. 38:157-165(1992).
RN   [3] {ECO:0000305}
RP   REVIEW.
RX   PubMed=15656969; DOI=10.1016/j.gene.2004.09.037;
RA   Pohl B.S., Knoechel W.;
RT   "Of fox and frogs: fox (fork head/winged helix) transcription factors in
RT   Xenopus development.";
RL   Gene 344:21-32(2005).
CC   -!- FUNCTION: Transcription factor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: First expressed within the dorsolateral ectoderm,
CC       except for the organizer territory. During gastrulation, expressed in 2
CC       ectodermal stripes adjacent to the dorsal midline. With the onset of
CC       neurulation, expression shifts first to the neural plate before
CC       settling on the bottom of the neural tube, on top of the notochord.
CC       Expression is then absent until stage 35, at which stage a pair of
CC       cells in the fourth rhombomere in the dorsolateral outer area of the
CC       rhombencephalon show expression. This is followed shortly afterwards by
CC       expression in a pair of cells in rhombomere 6 at the ventricular side
CC       of the rhombencephalon. {ECO:0000269|PubMed:12204271}.
CC   -!- DEVELOPMENTAL STAGE: Expression begins after the mid-blastula
CC       transition, peaks during gastrulation and is completely extinguished at
CC       the end of neurulation, before reappearing in swimming tadpoles.
CC       {ECO:0000269|PubMed:12204271}.
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DR   EMBL; AJ487619; CAD31848.1; -; Genomic_DNA.
DR   PIR; F56556; F56556.
DR   RefSeq; NP_001165547.1; NM_001172076.1.
DR   AlphaFoldDB; Q8JIT6; -.
DR   SMR; Q8JIT6; -.
DR   GeneID; 100337555; -.
DR   KEGG; xla:100337555; -.
DR   CTD; 100337555; -.
DR   Xenbase; XB-GENE-1021720; foxb2.S.
DR   OrthoDB; 1236900at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 100337555; Expressed in gastrula and 1 other tissue.
DR   GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; NAS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..317
FT                   /note="Forkhead box protein B2"
FT                   /id="PRO_0000257999"
FT   DNA_BIND        13..107
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
SQ   SEQUENCE   317 AA;  35294 MW;  79BAF21149FB02B1 CRC64;
     MPRPGKSSYS EQKPPYSYIS LTAMAIQGSQ EKMLPLSDIY KFIMDRFPYY RENTQRWQNS
     LRHNLSFNDC FIKIPRRPDQ PGKGSFWALH PNCGDMFENG SFLRRRKRFK VVRAEHLASK
     SHQMIHYFHH PHNQTKMGLP PSEGSPVPSL GRLPHFQSYN IGNISGNQTS GFKHPFAIEN
     IIGRDYKGVM TGGLPLASMM HHLGYPVPSQ ISNMVSSMWP HVGMMDSMAT MTVPQEYGHF
     GVPMKTLCHG PSQTIPAVPL PIKPTASLPP VSAIPSLAVN PSIMCPSPPA VAGTLLEPAI
     SQPENKSSML HSVLVHS