ID   FOXC2_XENTR             Reviewed;         464 AA.
AC   Q6NVT7;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 2.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Forkhead box protein C2;
DE            Short=FoxC2;
GN   Name=foxc2 {ECO:0000312|EMBL:AAH67916.1}; ORFNames=TGas062l07.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:CAJ83766.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula {ECO:0000312|EMBL:CAJ83766.1};
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:CAJ83766.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula {ECO:0000312|EMBL:CAJ83766.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional activator. May be involved in the dorso-
CC       ventral patterning of the mesoderm (By similarity).
CC       {ECO:0000250|UniProtKB:Q61850, ECO:0000250|UniProtKB:Q9PVY9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH67916.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAJ83766.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CR762327; CAJ83766.1; ALT_INIT; mRNA.
DR   EMBL; BC067916; AAH67916.1; ALT_INIT; mRNA.
DR   RefSeq; NP_998857.1; NM_213692.1.
DR   AlphaFoldDB; Q6NVT7; -.
DR   SMR; Q6NVT7; -.
DR   PaxDb; Q6NVT7; -.
DR   DNASU; 407875; -.
DR   GeneID; 407875; -.
DR   KEGG; xtr:407875; -.
DR   CTD; 2303; -.
DR   Xenbase; XB-GENE-481382; foxc2.
DR   eggNOG; KOG2294; Eukaryota.
DR   HOGENOM; CLU_035722_3_1_1; -.
DR   InParanoid; Q6NVT7; -.
DR   OMA; HMCAPST; -.
DR   OrthoDB; 1270467at2759; -.
DR   TreeFam; TF316127; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031490; F:chromatin DNA binding; ISS:UniProtKB.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:1990841; F:promoter-specific chromatin binding; ISS:UniProtKB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0001946; P:lymphangiogenesis; ISS:UniProtKB.
DR   GO; GO:0007498; P:mesoderm development; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0009725; P:response to hormone; ISS:UniProtKB.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..464
FT                   /note="Forkhead box protein C2"
FT                   /id="PRO_0000250440"
FT   DNA_BIND        72..166
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          168..196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          220..258
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          341..366
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        224..258
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   464 AA;  51432 MW;  9491112C89B27B63 CRC64;
     MMQARYSVAD PNALGVVPYL SEQNYYRAAG TYGSMATPMS VYPAHEQYTP GMARSYGPYH
     HHQPAAPKDL VKPPYSYIAL ITMAIQNAPD KKITLNGIYQ FIMDRFPFYR ENKQGWQNSI
     RHNLSLNECF VKVPRDDKKP GKGSYWTLDP DSYNMFENGS FLRRRRRFKK KDVSREKEDR
     ILKDQGKVQG PIPSLELPKH DKKIVIKSES PELPVITKVE NLSPDGGSAM QDSPRSVAST
     PSVSTENSIP DQHPASNGFS VENIMTLRTS PHGDLSPVPA VPCRTGMVPS LPINYTQTQS
     SVYSQACTQS MDTSGSYQCS MRAMSLYTGD RPSHMCAPST LEEATSDHHN GTASPLNSMS
     LGSGQESVLT SSHHQQTATG GQTAAPWYLN PGADISHLSG HNFGSQQQTF PNVREMFNSH
     RLGIESSALS EHQVSGNTSC QIPYRSAPSI YRHSSPYAYD CTKY