FOXD1_RAT
ID FOXD1_RAT Reviewed; 101 AA.
AC Q63251;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Forkhead box protein D1;
DE AltName: Full=Brain factor 2;
DE Short=BF-2;
DE AltName: Full=HFH-BF-2;
DE Flags: Fragment;
GN Name=Foxd1; Synonyms=Hfhbf2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley;
RX PubMed=7683413; DOI=10.1073/pnas.90.9.3948;
RA Clevidence D.E., Overdier D.G., Tao W., Qian X., Pani L., Lai E.,
RA Costa R.H.;
RT "Identification of nine tissue-specific transcription factors of the
RT hepatocyte nuclear factor 3/forkhead DNA-binding-domain family.";
RL Proc. Natl. Acad. Sci. U.S.A. 90:3948-3952(1993).
CC -!- FUNCTION: Transcription factor involved in regulation of gene
CC expression in a variety of processes including formation of positional
CC identity in the developing retina, regionalization of the optic chiasm,
CC morphogenesis of the kidney, and neuralization of ectodermal cells (By
CC similarity). Involved in transcriptional activation of PGF and C3 genes
CC (By similarity). {ECO:0000250|UniProtKB:Q16676,
CC ECO:0000250|UniProtKB:Q61345}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
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DR EMBL; L13192; AAA41324.1; -; mRNA.
DR PIR; I60922; I60922.
DR AlphaFoldDB; Q63251; -.
DR SMR; Q63251; -.
DR STRING; 10116.ENSRNOP00000053990; -.
DR PaxDb; Q63251; -.
DR UCSC; RGD:621712; rat.
DR RGD; 621712; Foxd1.
DR eggNOG; KOG2294; Eukaryota.
DR InParanoid; Q63251; -.
DR PhylomeDB; Q63251; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; ISO:RGD.
DR GO; GO:0008301; F:DNA binding, bending; ISO:RGD.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:RGD.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; ISO:RGD.
DR GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; ISO:RGD.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; ISO:RGD.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0060678; P:dichotomous subdivision of terminal units involved in ureteric bud branching; ISS:UniProtKB.
DR GO; GO:0001822; P:kidney development; ISO:RGD.
DR GO; GO:0032275; P:luteinizing hormone secretion; ISO:RGD.
DR GO; GO:0072213; P:metanephric capsule development; ISS:UniProtKB.
DR GO; GO:0072267; P:metanephric capsule specification; ISS:UniProtKB.
DR GO; GO:0072210; P:metanephric nephron development; ISO:RGD.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0072076; P:nephrogenic mesenchyme development; ISO:RGD.
DR GO; GO:0072268; P:pattern specification involved in metanephros development; ISO:RGD.
DR GO; GO:0030513; P:positive regulation of BMP signaling pathway; ISS:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR GO; GO:0090184; P:positive regulation of kidney development; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN <1..>101
FT /note="Forkhead box protein D1"
FT /id="PRO_0000091813"
FT DNA_BIND 3..97
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT NON_TER 1
FT NON_TER 101
SQ SEQUENCE 101 AA; 11929 MW; EB27289A88E31851 CRC64;
LVKPPYSYIA LITMAILQSP KKRLTLSEIC EFISGRFPYY REKFPAWQNS IRHNLSLNDC
FVKIPREPGN PGKGNYWTLD PESADMFDNG SFLRRRKRFK R
