FOXD1_XENLA
ID FOXD1_XENLA Reviewed; 345 AA.
AC Q9PSY4; O93613; Q32NK9;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Forkhead box protein D1;
DE Short=FoxD1;
DE AltName: Full=Brain factor 2;
DE Short=BF-2;
DE Short=xBF-2;
DE AltName: Full=Xbf2;
GN Name=foxd1 {ECO:0000303|PubMed:15656969};
GN Synonyms=bf-2 {ECO:0000312|EMBL:AAC78313.1},
GN bf2 {ECO:0000303|PubMed:10096060};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAC78313.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Neurula {ECO:0000269|PubMed:9811586};
RX PubMed=9811586; DOI=10.1242/dev.125.24.5019;
RA Mariani F.V., Harland R.M.;
RT "XBF-2 is a transcriptional repressor that converts ectoderm into neural
RT tissue.";
RL Development 125:5019-5031(1998).
RN [2] {ECO:0000305, ECO:0000312|EMBL:CAA09725.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Gastrula {ECO:0000269|PubMed:10096060};
RX PubMed=10096060; DOI=10.1016/s0925-4773(98)00190-7;
RA Gomez-Skarmeta J.L., de la Calle-Mustienes E., Modolell J., Mayor R.;
RT "Xenopus brain factor-2 controls mesoderm, forebrain and neural crest
RT development.";
RL Mech. Dev. 80:15-27(1999).
RN [3] {ECO:0000312|EMBL:AAI08578.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neurula {ECO:0000312|EMBL:AAI08578.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP REVIEW.
RX PubMed=15656969; DOI=10.1016/j.gene.2004.09.037;
RA Pohl B.S., Knoechel W.;
RT "Of fox and frogs: fox (fork head/winged helix) transcription factors in
RT Xenopus development.";
RL Gene 344:21-32(2005).
CC -!- FUNCTION: Transcriptional repressor that down-regulates bmp4 signaling
CC in both mesoderm and ectoderm. Regulates mesoderm patterning by
CC repressing ventral mesoderm genes and promoting the expression of
CC dorsolateral genes. Can also neuralize ectodermal cells directly.
CC Inhibits neural crest migration. The transcription factors foxd1 and
CC foxg1 mutually repress each other to pattern the forebrain.
CC {ECO:0000269|PubMed:10096060, ECO:0000269|PubMed:9811586}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089,
CC ECO:0000269|PubMed:9811586}.
CC -!- TISSUE SPECIFICITY: Expressed in gastrula (stage 10) embryos in the
CC dorsolateral mesoderm, where expression continues until mesoderm
CC involution. In early neurula embryos (stage 12.5), expressed in the
CC anterior neural plate in the prospective diencephalon and eye field,
CC and in the anterior neural folds, with expression becoming stronger as
CC neurulation proceeds. At stage 14, transiently expressed in two stripes
CC lateral to the midline. Expressed in premigratory, but not migratory,
CC cephalic neural crest cells. At stage 20, expressed in the paraxial
CC mesoderm and in the optic vesicle. At stage 21, expression continues in
CC the forebrain and begins in cells lateral to the rostral somites as
CC well as in the neural tissue of the tailbud. By stage 36, detected in
CC restricted regions of the forebrain and in the temporal retina.
CC Caudally, expression continues in the neural tissue of the tailbud. At
CC this stage, there is also strong expression at the caudal (tail) end of
CC the embryo on the ventral side. {ECO:0000269|PubMed:10096060,
CC ECO:0000269|PubMed:9811586}.
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DR EMBL; AF072889; AAC78313.1; -; mRNA.
DR EMBL; AJ011652; CAA09725.1; -; mRNA.
DR EMBL; BC108577; AAI08578.1; -; mRNA.
DR RefSeq; NP_001079052.1; NM_001085583.1.
DR AlphaFoldDB; Q9PSY4; -.
DR SMR; Q9PSY4; -.
DR PRIDE; Q9PSY4; -.
DR DNASU; 373583; -.
DR GeneID; 373583; -.
DR KEGG; xla:373583; -.
DR CTD; 373583; -.
DR Xenbase; XB-GENE-865762; foxd1.L.
DR OMA; HAGTIIP; -.
DR OrthoDB; 1270467at2759; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR Bgee; 373583; Expressed in neurula embryo and 7 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0007398; P:ectoderm development; IMP:UniProtKB.
DR GO; GO:0030900; P:forebrain development; IMP:UniProtKB.
DR GO; GO:0007498; P:mesoderm development; IMP:UniProtKB.
DR GO; GO:0030336; P:negative regulation of cell migration; IMP:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0007399; P:nervous system development; IMP:UniProtKB.
DR GO; GO:0001755; P:neural crest cell migration; IMP:UniProtKB.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..345
FT /note="Forkhead box protein D1"
FT /id="PRO_0000253929"
FT DNA_BIND 68..162
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..37
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 29
FT /note="E -> V (in Ref. 1; AAC78313)"
FT /evidence="ECO:0000305"
FT CONFLICT 229
FT /note="A -> V (in Ref. 3; AAI08578)"
FT /evidence="ECO:0000305"
FT CONFLICT 272
FT /note="L -> F (in Ref. 2; CAA09725)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 345 AA; 38049 MW; 8BE2838A509B707F CRC64;
MTLSSDMSDV LAEETDIDVV GEEDEPRAEE EEEEDGELLM PRSPHCSSTK DPYKAAGSGG
VGRSALVKPP YSYIALITMS ILQSPKKRLT LSEICDFISS RFPYYREKFP AWQNSIRHNL
SLNDCFVKIP REPGNPGKGN YWTLDPESAD MFDNGSFLRR RKRFKRQQVP ELVLREPGHF
LPASAYGYGP YSCAYGIQIQ PFHPHSALIA FQQQQQHQQQ QARHQQQQAR HQQQQARHQQ
QPPSLPSMAA PALMPPAAQD LSRTCTFYPH QLSPAALPPS LQSKSSSALA RSTFSIESII
GGDLNPGPKA AGVPVISRAL VTFSSSEAAA ALGGNLQPGT VLTNH
