ID   FOXD1_XENTR             Reviewed;         329 AA.
AC   Q6F2E4;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Forkhead box protein D1;
DE            Short=FoxD1;
DE   AltName: Full=Brain factor 2;
DE            Short=BF-2;
GN   Name=foxd1 {ECO:0000312|EMBL:AAH81361.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAT73696.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Qin S., Dors M., Johnson E., Bloom S., Hood L., Rowen L.;
RT   "Sequence of Xenopus tropicalis development genes.";
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:AAT73696.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAH81361.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor that down-regulates bmp4 signaling
CC       in both mesoderm and ectoderm. Regulates mesoderm patterning by
CC       repressing ventral mesoderm genes and promoting the expression of
CC       dorsolateral genes. Can also neuralize ectodermal cells directly.
CC       Inhibits neural crest migration. The transcription factors foxd1 and
CC       foxg1 mutually repress each other to pattern the forebrain (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
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DR   EMBL; AC149037; AAT73696.1; -; Genomic_DNA.
DR   EMBL; BC081361; AAH81361.1; -; mRNA.
DR   RefSeq; NP_001008148.1; NM_001008147.1.
DR   AlphaFoldDB; Q6F2E4; -.
DR   SMR; Q6F2E4; -.
DR   PaxDb; Q6F2E4; -.
DR   DNASU; 493510; -.
DR   Ensembl; ENSXETT00000076858; ENSXETP00000070899; ENSXETG00000035456.
DR   GeneID; 493510; -.
DR   KEGG; xtr:493510; -.
DR   CTD; 2297; -.
DR   Xenbase; XB-GENE-488077; foxd1.
DR   eggNOG; KOG2294; Eukaryota.
DR   HOGENOM; CLU_040357_5_0_1; -.
DR   InParanoid; Q6F2E4; -.
DR   OMA; HAGTIIP; -.
DR   OrthoDB; 1270467at2759; -.
DR   PhylomeDB; Q6F2E4; -.
DR   TreeFam; TF316127; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000035456; Expressed in neurula embryo and 5 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0007398; P:ectoderm development; ISS:UniProtKB.
DR   GO; GO:0030900; P:forebrain development; ISS:UniProtKB.
DR   GO; GO:0007498; P:mesoderm development; ISS:UniProtKB.
DR   GO; GO:0030336; P:negative regulation of cell migration; ISS:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0007399; P:nervous system development; ISS:UniProtKB.
DR   GO; GO:0001755; P:neural crest cell migration; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..329
FT                   /note="Forkhead box protein D1"
FT                   /id="PRO_0000253930"
FT   DNA_BIND        68..162
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          1..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..37
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   329 AA;  35831 MW;  1E716C8AEE441B14 CRC64;
     MTLSSDMSDV LAEETDIDVV GEDDEPRAEE EEDEDLHGDL LPTSPQSSAT KDPYKGTGGG
     GGRSALVKPP YSYIALITMA ILQSPKKRLT LSEICEFISN RFPYYREKFP AWQNSIRHNL
     SLNDCFVKIP REPGNPGKGN YWTLDPESAD MFDNGSFLRR RKRFKRQQAP ELVLREPGHF
     LPASAYSYGP YSCAYGIQLQ PFHPHSALIA FQQQQQQARQ QPPSLPPMAA PALMPPAAQD
     LSRTCTFYPH QLSPAALPPS LQSKSSSALA RSTFSIESII GGDLNPGQCN SPKAAGVPVI
     SRALVTFSSS QAAAALGGTL QPGTVLTNH