FOXD2_MOUSE
ID FOXD2_MOUSE Reviewed; 492 AA.
AC O35392; A2AD43;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Forkhead box protein D2;
DE AltName: Full=Mesoderm/mesenchyme forkhead 2;
DE Short=MF-2;
GN Name=Foxd2; Synonyms=Mf2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Mesenchymal cell;
RX PubMed=9510020; DOI=10.1016/s0925-4773(97)00157-3;
RA Wu S.C.-Y., Grindley J., Winnier G.E., Hargett L., Hogan B.L.M.;
RT "Mouse mesenchyme forkhead 2 (Mf2): expression, DNA binding and induction
RT by sonic hedgehog during somitogenesis.";
RL Mech. Dev. 70:3-13(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Probable transcription factor involved in embryogenesis and
CC somatogenesis. {ECO:0000269|PubMed:9510020}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed at high levels in the ventral region of
CC newly formed somites, in sclerotomal derivatives, in lateral plate and
CC cephalic mesoderm and in the first and second branchial arches. Other
CC regions of mesodermal expression include the developing tongue,
CC meninges, nose, whiskers, kidney, genital tubercule and limb joints. In
CC the nervous system it is transcribed in restricted regions of the
CC mid- and forebrain. {ECO:0000269|PubMed:9510020}.
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DR EMBL; AF023915; AAB81275.1; -; mRNA.
DR EMBL; AL670035; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS18482.1; -.
DR RefSeq; NP_032619.1; NM_008593.3.
DR AlphaFoldDB; O35392; -.
DR SMR; O35392; -.
DR STRING; 10090.ENSMUSP00000066868; -.
DR iPTMnet; O35392; -.
DR PhosphoSitePlus; O35392; -.
DR PaxDb; O35392; -.
DR PeptideAtlas; O35392; -.
DR PRIDE; O35392; -.
DR ProteomicsDB; 271792; -.
DR Antibodypedia; 32890; 116 antibodies from 21 providers.
DR DNASU; 17301; -.
DR Ensembl; ENSMUST00000068654; ENSMUSP00000066868; ENSMUSG00000055210.
DR GeneID; 17301; -.
DR KEGG; mmu:17301; -.
DR UCSC; uc012dix.1; mouse.
DR CTD; 2306; -.
DR MGI; MGI:1347471; Foxd2.
DR VEuPathDB; HostDB:ENSMUSG00000055210; -.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000157140; -.
DR HOGENOM; CLU_040357_5_0_1; -.
DR InParanoid; O35392; -.
DR OMA; GCCCEIM; -.
DR OrthoDB; 1270467at2759; -.
DR PhylomeDB; O35392; -.
DR TreeFam; TF316127; -.
DR BioGRID-ORCS; 17301; 0 hits in 74 CRISPR screens.
DR ChiTaRS; Foxd2; mouse.
DR PRO; PR:O35392; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; O35392; protein.
DR Bgee; ENSMUSG00000055210; Expressed in lumbar dorsal root ganglion and 103 other tissues.
DR Genevisible; O35392; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..492
FT /note="Forkhead box protein D2"
FT /id="PRO_0000091816"
FT DNA_BIND 129..223
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 13..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 96
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O60548"
SQ SEQUENCE 492 AA; 48937 MW; 7F82440F4C435702 CRC64;
MTLGSCCCEI MSSESSPAAL SEPDADIDVV GGGSGGGELT ARSGPRAPRD VLPHGHEPPP
EEAEADVAED EEESGGCSDC EPRALAPRGA AAAAGSPGPG VQAARGATGP GPGPGPPSGG
AATRSPLVKP PYSYIALITM AILQSPKKRL TLSEICEFIS GRFPYYREKF PAWQNSIRHN
LSLNDCFVKI PREPGNPGKG NYWTLDPESA DMFDNGSFLR RRKRFKRQPL PPPHPHPHPH
PELLLRGGAA AAGDPGAFLS SFAAYGAYGY GYGLALPAYG APPPGPAPHP HPHPHAFAFA
ATAPCQLSVP PGRAAAPPPG PPTASVFASA ASAPAPAPAP GSGPSPAGLP AFLGAELGCA
KAFYPASLSP PAAGTAASLS TALLRQGLKT DAGGGAGGGG AGTGQRPSFS IDHIMGHGGG
GAAPPGSGDG SPGSPFAAAA GPGGQAQVLA MLTAPALTPV AGHIRLSHPG DSLLSSGPSF
ASKVAGLSGC HF
