FOXD2_XENLA
ID FOXD2_XENLA Reviewed; 346 AA.
AC Q90WN4; Q32NL7; Q9PS86;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Forkhead box protein D2;
DE Short=FoxD2;
DE Short=xFoxD2;
DE AltName: Full=Fork head domain-related protein 9;
DE Short=xFD-9;
DE AltName: Full=Forkhead protein 3;
DE Short=FKH-3;
DE Short=xFKH3;
GN Name=foxd2 {ECO:0000312|EMBL:CAC69867.1}; Synonyms=fkh3;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAC69867.1}
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC TISSUE=Neurula {ECO:0000269|PubMed:11804794};
RX PubMed=11804794; DOI=10.1016/s0925-4773(01)00617-7;
RA Pohl B.S., Knoechel W.;
RT "Temporal and spatial expression patterns of FoxD2 during the early
RT development of Xenopus laevis.";
RL Mech. Dev. 111:181-184(2002).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAI08570.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neurula {ECO:0000312|EMBL:AAI08570.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-223, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RA Scheucher M., Dege P., Lef J., Hille S., Knoechel W.;
RT "Transcription patterns of four different fork head/HNF-3 related genes
RT (XFD-4, 6, 9 and 10) in Xenopus laevis embryos.";
RL Roux's Arch. Dev. Biol. 204:203-211(1995).
RN [4] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 78-139, AND TISSUE SPECIFICITY.
RC TISSUE=Embryo {ECO:0000269|PubMed:7586752};
RX PubMed=7586752; DOI=10.1002/dvg.1020170203;
RA Dirksen M.-L., Jamrich M.;
RT "Differential expression of fork head genes during early Xenopus and
RT zebrafish development.";
RL Dev. Genet. 17:107-116(1995).
RN [5] {ECO:0000305}
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=8735935;
RA Lef J., Dege P., Scheucher M., Forsbach-Birk V., Clement J.H., Knoechel W.;
RT "A fork head related multigene family is transcribed in Xenopus laevis
RT embryos.";
RL Int. J. Dev. Biol. 40:245-253(1996).
RN [6] {ECO:0000305}
RP NOMENCLATURE.
RX PubMed=10702024;
RA Kaestner K.H., Knoechel W., Martinez D.E.;
RT "Unified nomenclature for the winged helix/forkhead transcription
RT factors.";
RL Genes Dev. 14:142-146(2000).
RN [7] {ECO:0000305}
RP REVIEW.
RX PubMed=15656969; DOI=10.1016/j.gene.2004.09.037;
RA Pohl B.S., Knoechel W.;
RT "Of fox and frogs: fox (fork head/winged helix) transcription factors in
RT Xenopus development.";
RL Gene 344:21-32(2005).
CC -!- FUNCTION: Probable transcription factor. {ECO:0000269|PubMed:15656969}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Absent from the notochord. First located in the
CC neuroectoderm of gastrula stage embryos. Located within the paraxial
CC mesoderm of neurulae, but not within the myotome. In tailbud embryos,
CC strongly expressed in the developing somites, with levels highest at
CC the dorsal and ventral margins. Beginning at stage 25, additional
CC expression is observed within migrating ventral abdominal muscle
CC precursors, in cranial neural crest cells surrounding the eye and in
CC cranial crest cells that migrate to the second and third visceral
CC arches. Also expressed in the diencephalon. At stage 31, expressed
CC diffusely in the proctodeum, becoming concentrated within the terminal
CC part of the gut in hatched tadpoles. In the head, expressed in the
CC facial mesenchyme being most prominent at the site where the two halves
CC of the lower jaw fuse. {ECO:0000269|PubMed:11804794,
CC ECO:0000269|PubMed:7586752, ECO:0000269|PubMed:8735935,
CC ECO:0000269|Ref.3}.
CC -!- DEVELOPMENTAL STAGE: Zygotic expression begins at the late gastrula
CC stage, increases during neurulation and becomes most abundant at
CC tailbud stages, then continues at a lower level in tadpoles.
CC {ECO:0000269|PubMed:11804794, ECO:0000269|PubMed:8735935,
CC ECO:0000269|Ref.3}.
CC -!- CAUTION: Was originally thought to be a FoxD1 protein but further
CC sequence comparisons (PubMed:11804794 and PubMed:15656969) clearly
CC suggests that it belongs to the FoxD2 subclass.
CC {ECO:0000305|PubMed:10702024}.
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DR EMBL; AJ344435; CAC69867.1; -; mRNA.
DR EMBL; BC108569; AAI08570.1; -; mRNA.
DR RefSeq; NP_001079322.1; NM_001085853.1.
DR AlphaFoldDB; Q90WN4; -.
DR SMR; Q90WN4; -.
DR DNASU; 378641; -.
DR GeneID; 378641; -.
DR KEGG; xla:378641; -.
DR CTD; 378641; -.
DR Xenbase; XB-GENE-865311; foxd2.S.
DR OMA; KNPNMNT; -.
DR OrthoDB; 1270467at2759; -.
DR Proteomes; UP000186698; Chromosome 4S.
DR Bgee; 378641; Expressed in neurula embryo and 4 other tissues.
DR GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; NAS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..346
FT /note="Forkhead box protein D2"
FT /id="PRO_0000250607"
FT DNA_BIND 78..172
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 1..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 323
FT /note="A -> S (in Ref. 2; AAI08570)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 346 AA; 38296 MW; B12195FAC6F90CF2 CRC64;
MTLGTEMSDN SLLSEDTDID VVGDMGAKDG KYSDYHSDND SDDNVARTPR GDPASPDLSS
GSESNQRAEK SPKNALVKPP YSYIALITMS ILQSPKKRLT LSEICEFISN RFPYYREKFP
AWQNSIRHNL SLNDCFVKIP REPGNPGKGN YWTLDPESAD MFDNGSFLRR RKRFKRQQSN
EILRDPSSFM PAAFGYGPYG YNYGLQLHNY QQHPGATFSF QPSHCPLPPP ASVFSSPTLS
PFLGNELSRK SLYSQLSPTL PILHTLKPDA QSRPSFSIDN IIGGSGSTPS PTSPYTAQPG
THPPVIAMLS PSLAPMHNHL NLAHENLLPP GQNFSSKITN LNSCHF
