ID   FOXD3_CHICK             Reviewed;         394 AA.
AC   P79772;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Forkhead box protein D3;
DE   AltName: Full=HNF3/FH transcription factor genesis;
DE   AltName: Full=Winged-helix protein CWH-3;
GN   Name=FOXD3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo;
RX   PubMed=8988052;
RA   Freyaldenhoven B.S., Freyaldenhoven M.P., Iacovoni J.S., Vogt P.K.;
RT   "Aberrant cell growth induced by avian winged helix proteins.";
RL   Cancer Res. 57:123-129(1997).
RN   [2]
RP   FUNCTION.
RX   PubMed=11684651; DOI=10.1242/dev.128.21.4127;
RA   Dottori M., Gross M.K., Labosky P., Goulding M.;
RT   "The winged-helix transcription factor Foxd3 suppresses interneuron
RT   differentiation and promotes neural crest cell fate.";
RL   Development 128:4127-4138(2001).
CC   -!- FUNCTION: Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and
CC       acts as a transcriptional repressor. Also acts as a transcriptional
CC       activator. Promotes development of neural crest cells from neural tube
CC       progenitors. Restricts neural progenitor cells to the neural crest
CC       lineage while suppressing interneuron differentiation. Required for
CC       maintenance of pluripotent cells in the pre-implantation and peri-
CC       implantation stages of embryogenesis. {ECO:0000269|PubMed:11684651}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; U37274; AAC60066.1; -; mRNA.
DR   AlphaFoldDB; P79772; -.
DR   SMR; P79772; -.
DR   PaxDb; P79772; -.
DR   VEuPathDB; HostDB:geneid_395794; -.
DR   InParanoid; P79772; -.
DR   OrthoDB; 1270467at2759; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0043009; P:chordate embryonic development; IDA:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..394
FT                   /note="Forkhead box protein D3"
FT                   /id="PRO_0000091820"
FT   DNA_BIND        117..211
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          1..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   394 AA;  40995 MW;  324A4B36B9E31899 CRC64;
     MTLSGGGSDM SGQTALAAED VDIDVVGEGD DAPGKDGDGE ARSPAALPLP LDEAAEPGEP
     ERAARRAAAA RQPGPGRPEG GRGGGGGGGG GEEGASGGGA AAAAAAGQSK PKSSLVKPPY
     SYIALITMAI LQSPQKKLTL SGICEFISNR FPYYREKFPA WQNSIRHNLS LNDCFVKIPR
     EPGNPGKGNY WTLDPQSEDM FDNGSFLRRR KRFKRHQQEH LRDQTALMMQ GFGAYGLAGP
     YGRPYGLPPG AYPHPAALQY PYIPPVGPML PPACPLLPSG ELSRKAFNAQ LGPSLQLQLS
     SLGAAGSIVK SEPSSRPSFS IENIIGGPAA SSAPSAQTFL RPPVTVQSGL VAHQPLALAR
     TTAAIAPILS VPTNIIAGQF LQPPAAVQAK WPAQ