FOXD3_XENTR
ID FOXD3_XENTR Reviewed; 369 AA.
AC Q5M7L9;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Forkhead box protein D3;
DE Short=FoxD3;
GN Name=foxd3 {ECO:0000312|EMBL:CAJ82837.1}; ORFNames=TNeu088c09.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000312|EMBL:CAJ82837.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neurula {ECO:0000312|EMBL:CAJ82837.1};
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|EMBL:CAJ82837.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastrula {ECO:0000312|EMBL:AAH88566.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional repressor that is an essential upstream
CC regulator of neural crest determination. Also acts in a negative auto-
CC regulator loop by inhibiting the transcription of its own gene (By
CC similarity). {ECO:0000250|UniProtKB:Q9DEN4}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
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DR EMBL; CR760163; CAJ82837.1; -; mRNA.
DR EMBL; BC088566; AAH88566.1; -; mRNA.
DR RefSeq; NP_001011383.1; NM_001011383.1.
DR AlphaFoldDB; Q5M7L9; -.
DR SMR; Q5M7L9; -.
DR STRING; 8364.ENSXETP00000023699; -.
DR PaxDb; Q5M7L9; -.
DR DNASU; 496851; -.
DR Ensembl; ENSXETT00000023699; ENSXETP00000023699; ENSXETG00000010836.
DR GeneID; 496851; -.
DR KEGG; xtr:496851; -.
DR CTD; 27022; -.
DR Xenbase; XB-GENE-487289; foxd3.
DR eggNOG; KOG2294; Eukaryota.
DR HOGENOM; CLU_040357_0_1_1; -.
DR InParanoid; Q5M7L9; -.
DR OMA; GECDEGM; -.
DR OrthoDB; 1270467at2759; -.
DR PhylomeDB; Q5M7L9; -.
DR TreeFam; TF316127; -.
DR Proteomes; UP000008143; Chromosome 4.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000010836; Expressed in neurula embryo and 22 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0060351; P:cartilage development involved in endochondral bone morphogenesis; IEA:Ensembl.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0048484; P:enteric nervous system development; IEA:Ensembl.
DR GO; GO:0050935; P:iridophore differentiation; IEA:Ensembl.
DR GO; GO:0048937; P:lateral line nerve glial cell development; IEA:Ensembl.
DR GO; GO:0030318; P:melanocyte differentiation; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0050768; P:negative regulation of neurogenesis; ISS:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0014034; P:neural crest cell fate commitment; ISS:UniProtKB.
DR GO; GO:0001755; P:neural crest cell migration; IEA:Ensembl.
DR GO; GO:0007422; P:peripheral nervous system development; IEA:Ensembl.
DR GO; GO:0050769; P:positive regulation of neurogenesis; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0097066; P:response to thyroid hormone; IEA:Ensembl.
DR GO; GO:0048485; P:sympathetic nervous system development; IEA:Ensembl.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..369
FT /note="Forkhead box protein D3"
FT /id="PRO_0000250610"
FT DNA_BIND 92..186
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..57
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..89
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 369 AA; 39637 MW; 67F15CB9FE041850 CRC64;
MTLSGSSSAS DMSGQTVLSA DDADIDVVGE GDEPLDKDSE CGSPAGHAEE ADELGGKEIA
RSPSGSANEA EGKGESQQQE GMQNKPKNSL VKPPYSYIAL ITMAILQSPQ KKLTLSGICE
FISNRFPYYR EKFPAWQNSI RHNLSLNDCF VKIPREPGNP GKGNYWTLDP QSEDMFDNGS
FLRRRKRFKR QQPDSLREQT ALMMQSFGAY SLAGPYGRPY GLHPAAYTHP AALQYPYIPP
VGPMLPPAVP LLPSSELSRK AFSSQLSPSL QLQLSSLSST AASIIKSEPS SRPSFSIENI
IGVSAASSIA PQTFLRPPVT VQSALMSHQP LALSRSTAAI GPILSVPTNL ISGQFLPTAA
AAVAKWPAQ
