FOXD4_MOUSE
ID FOXD4_MOUSE Reviewed; 444 AA.
AC Q60688; B2RRJ0; Q61573;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Forkhead box protein D4;
DE AltName: Full=Forkhead-related protein FKHL9;
DE AltName: Full=Forkhead-related transcription factor 5;
DE Short=FREAC-5;
DE AltName: Full=Transcription factor FKH-2;
GN Name=Foxd4; Synonyms=Fkh2, Fkhl9, Freac5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/Sv;
RX PubMed=8530406; DOI=10.1074/jbc.270.50.30029;
RA Kaestner K.H., Monaghan A.P., Kern H., Ang S.-L., Weitz S., Lichter P.,
RA Schuetz G.;
RT "The mouse fkh-2 gene. Implications for notochord, foregut, and midbrain
RT regionalization.";
RL J. Biol. Chem. 270:30029-30035(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 94-204.
RC STRAIN=129;
RX PubMed=7689224; DOI=10.1073/pnas.90.16.7628;
RA Kaestner K.H., Lee K.H., Schloendorff J., Hiemisch H., Monaghan A.P.,
RA Schuetz G.;
RT "Six members of the mouse forkhead gene family are developmentally
RT regulated.";
RL Proc. Natl. Acad. Sci. U.S.A. 90:7628-7631(1993).
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Not detected in any adult tissues tested.
CC -!- DEVELOPMENTAL STAGE: Expressed in headfold stage embryos in the
CC notochord, the anterior neuroectoderm, and a few cells of the definite
CC endoderm. This expression becomes restricted to the anteriormost
CC portions of the invaginating foregut and the developing midbrain. From
CC day 11.5 of gestation onward, FOXD4 transcripts are restricted to the
CC midbrain and become progressively localized to the red nuclei as the
CC sole site of expression.
CC -!- DOMAIN: Contains two potential transactivation domains A and B.
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DR EMBL; X86368; CAA60128.1; -; Genomic_DNA.
DR EMBL; BC138432; AAI38433.1; -; mRNA.
DR EMBL; BC138434; AAI38435.1; -; mRNA.
DR EMBL; X71940; CAA50742.1; -; Genomic_DNA.
DR CCDS; CCDS29715.1; -.
DR PIR; B47746; B47746.
DR RefSeq; NP_032048.1; NM_008022.2.
DR AlphaFoldDB; Q60688; -.
DR SMR; Q60688; -.
DR STRING; 10090.ENSMUSP00000058575; -.
DR iPTMnet; Q60688; -.
DR PhosphoSitePlus; Q60688; -.
DR PaxDb; Q60688; -.
DR PRIDE; Q60688; -.
DR ProteomicsDB; 271712; -.
DR DNASU; 14237; -.
DR Ensembl; ENSMUST00000058600; ENSMUSP00000058575; ENSMUSG00000051490.
DR GeneID; 14237; -.
DR KEGG; mmu:14237; -.
DR UCSC; uc008hav.1; mouse.
DR CTD; 2298; -.
DR MGI; MGI:1347467; Foxd4.
DR VEuPathDB; HostDB:ENSMUSG00000051490; -.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000163353; -.
DR HOGENOM; CLU_040357_3_0_1; -.
DR InParanoid; Q60688; -.
DR OMA; CAISCAP; -.
DR OrthoDB; 1270467at2759; -.
DR PhylomeDB; Q60688; -.
DR TreeFam; TF316127; -.
DR BioGRID-ORCS; 14237; 4 hits in 73 CRISPR screens.
DR PRO; PR:Q60688; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q60688; protein.
DR Bgee; ENSMUSG00000051490; Expressed in granulocyte and 25 other tissues.
DR Genevisible; Q60688; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..444
FT /note="Forkhead box protein D4"
FT /id="PRO_0000091822"
FT DNA_BIND 102..193
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..47
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..256
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 201..204
FT /note="RHHP -> PTTR (in Ref. 3; CAA50742)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 444 AA; 48047 MW; FFDC8EDDC6FC18FE CRC64;
MNSARAGHLR STPPPSPLSS DQDEVEIDVL AEEEDGDQTE EEDDEEESHK CLERSLQRPG
ARTLAGRSAG DCGDLSNSSG FLRKFRAPRT PATTTADGPQ PAKPPYSYIA LITMAILQSP
HKRLTLSGIC AFISGRFPYY RRKFPAWQNS IRHNLSLNDC FVKIPREPGH PGKGNYWSLD
PASQDMFDNG SFLRRRKRFK RHHPPSGGHP HCPFPPPAVP ATLHVSQPSL LLRYSAPPQP
NLAAHPAAPP RSHPCAPLHP HPMRYLLLAA PAYGDNPRKA EGADPATPLA IPALQPVLGS
QPWERDQSSG TRSGRGCASF TIESIMQGVT GGGTGSAQSP SFAPWSYCHL LQHPPCLLHP
QAASPLFHMS AGSRTILPQQ PQPPLPLQQE QHHCAISCAP GKGVRLGQHL SAVAALLRQQ
PAADDGRLTT LAALSGREGT LPEF
