ID   FOXD5_XENTR             Reviewed;         352 AA.
AC   Q5WM45; Q28F09;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Forkhead box protein D5;
DE            Short=FoxD5;
DE   AltName: Full=XtFoxD5;
GN   Name=foxd5 {ECO:0000312|EMBL:CAH64539.1}; ORFNames=TGas140e03.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:CAH64539.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX   PubMed=15555577; DOI=10.1016/j.bbrc.2004.10.177;
RA   Schoen C., Koester M., Knoechel W.;
RT   "A downstream enhancer is essential for Xenopus FoxD5 transcription.";
RL   Biochem. Biophys. Res. Commun. 325:1360-1366(2004).
RN   [2] {ECO:0000312|EMBL:CAJ81989.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula {ECO:0000312|EMBL:CAJ81989.1};
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor. {ECO:0000250|UniProtKB:Q9PRJ8}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expression begins in the newly forming dorsal
CC       mesoderm and is maintained during gastrulation at the dorsal blastopore
CC       lip (Spemann organizer). At the early neurula stages, expressed in a
CC       row of cells along the dorsal midline that are destined to become the
CC       fllor plate of the neural tube. At late neurula, expressed within the
CC       anterior and posterior poles of the embryo. After neural closure,
CC       expression is detected only in the tailtip, the otic vesicle and at the
CC       midbrain/hindbrain boundary. {ECO:0000269|PubMed:15555577}.
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DR   EMBL; AJ850137; CAH64539.1; -; Genomic_DNA.
DR   EMBL; CR762235; CAJ81989.1; -; mRNA.
DR   RefSeq; NP_001016928.1; NM_001016928.1.
DR   AlphaFoldDB; Q5WM45; -.
DR   SMR; Q5WM45; -.
DR   PaxDb; Q5WM45; -.
DR   GeneID; 549682; -.
DR   KEGG; xtr:549682; -.
DR   CTD; 549682; -.
DR   Xenbase; XB-GENE-479247; foxd4l1.1.
DR   eggNOG; KOG2294; Eukaryota.
DR   InParanoid; Q5WM45; -.
DR   OrthoDB; 1270467at2759; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..352
FT                   /note="Forkhead box protein D5"
FT                   /id="PRO_0000259618"
FT   DNA_BIND        97..191
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          47..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..85
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        247
FT                   /note="A -> S (in Ref. 2; CAJ81989)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   352 AA;  39652 MW;  63FCC046E965BC46 CRC64;
     MSLSQESGAH HDPQDYPVVS DEEDEIDILG EDDSCSLKSH FYLQPTHSEM GDSGILSPSK
     LSCTESESDS SGESEGGTSK DSPATPSGGK AKRALVKPPY SYIALITMAI LQSPHKKLTL
     SGICDFISSK FPYYKDKFPA WQNSIRHNLS LNDCFIKIPR EPGNPGKGNY WTLDPASEDM
     FDNGSFLRRR KRFKRHQQEF FKDGLVMYNP LPYYRPYSTI QPQQVLQQTP VACMAIPENL
     TMPTHLAPYP DIKRKVPYPD QGVHRGFEAL DADNHPNKSQ SKCSFSIENI MRKPKEPEPS
     FSTFNPHWNY NHLLQRPNSC LLPAVLNLST GPLLSNAQGT RQYNLIKFPG CY