ID   FOXE1_XENLA             Reviewed;         379 AA.
AC   Q5J3Q5;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Forkhead box protein E1;
DE            Short=FoxE1;
GN   Name=foxe1 {ECO:0000250|UniProtKB:O00358};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAS82575.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Embryonic head {ECO:0000269|PubMed:16172985};
RX   PubMed=16172985; DOI=10.1387/ijdb.052011he;
RA   El-Hodiri H.M., Seufert D.W., Nekkalapudi S., Prescott N.L., Kelly L.E.,
RA   Jamrich M.;
RT   "Xenopus laevis FoxE1 is primarily expressed in the developing pituitary
RT   and thyroid.";
RL   Int. J. Dev. Biol. 49:881-884(2005).
CC   -!- FUNCTION: Transcription factor that binds consensus sites on a variety
CC       of gene promoters and activate their transcription.
CC       {ECO:0000250|UniProtKB:O00358}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O00358}.
CC   -!- TISSUE SPECIFICITY: First expressed at late neural tube and early
CC       tailbud stages in the hypophyseal placode. Expression continues in the
CC       developing pituitary at late tailbud stages. As development progresses,
CC       expressed in the mesoderm of the branchial arches. At stage 38,
CC       expressed in the developing thyroid and in the pharyngeal endoderm.
CC       {ECO:0000269|PubMed:16172985}.
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DR   EMBL; AY509892; AAS82575.1; -; mRNA.
DR   RefSeq; NP_001089013.1; NM_001095544.2.
DR   RefSeq; XP_018104746.1; XM_018249257.1.
DR   AlphaFoldDB; Q5J3Q5; -.
DR   SMR; Q5J3Q5; -.
DR   GeneID; 496399; -.
DR   KEGG; xla:496399; -.
DR   CTD; 496399; -.
DR   Xenbase; XB-GENE-865189; foxe1.L.
DR   OMA; QPAGCTG; -.
DR   OrthoDB; 1270467at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 496399; Expressed in egg cell and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISS:UniProtKB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..379
FT                   /note="Forkhead box protein E1"
FT                   /id="PRO_0000259399"
FT   DNA_BIND        66..160
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          1..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          239..265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..27
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   379 AA;  41708 MW;  E07133425592C5E0 CRC64;
     MTAESQQSPT RATAAGAGLQ QTSGFTMPVV KVEKDPAPEA SMSNGGSEVD DTHKGRRRKR
     PLQKGKPPYS YIALIAMSIA NSADRKLTLG GIYKFITERF PFYRDNSKKW QNSIRHNLTL
     NDCFIKIPRE PGRPGKGNYW ALDPNAEDMF DSGSFLRRRK RFKRTDLTTY PAYIHDTSMF
     SPLQVARATY PNTVYPNMTM SPNYSQQIAP HSSVYYPSSS PAFSSAQPRV FSINTLIGHS
     GSEHAQPPNR SISPEVNSTS SSSCNYGGSA YSSQAGSGTM LPRSTNPVPY SYSVPNSHLQ
     MNQSTYTHSN AQLFGSASRL PMPTSPPMNS DTVDFYGRMS PGQYTSLATY NSNGQLGGTN
     AYLRHATYSG NMERFVPAV