ID   FOXE4_XENLA             Reviewed;         365 AA.
AC   Q9PTK2;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Forkhead box protein E4;
DE            Short=FoxE4;
DE   AltName: Full=Xlens1;
GN   Name=foxe4 {ECO:0000303|PubMed:15656969};
GN   Synonyms=lens1 {ECO:0000312|EMBL:AAF20385.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAF20385.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RC   TISSUE=Embryonic head {ECO:0000269|PubMed:10529427};
RX   PubMed=10529427; DOI=10.1242/dev.126.22.5107;
RA   Kenyon K.L., Moody S.A., Jamrich M.;
RT   "A novel fork head gene mediates early steps during Xenopus lens
RT   formation.";
RL   Development 126:5107-5116(1999).
RN   [2] {ECO:0000305}
RP   REVIEW.
RX   PubMed=15656969; DOI=10.1016/j.gene.2004.09.037;
RA   Pohl B.S., Knoechel W.;
RT   "Of fox and frogs: fox (fork head/winged helix) transcription factors in
RT   Xenopus development.";
RL   Gene 344:21-32(2005).
CC   -!- FUNCTION: Probable transcription factor. Mediates lens formation in the
CC       embryo by promoting the proliferation of the specified lens ectoderm
CC       and suppressing its terminal differentiation.
CC       {ECO:0000269|PubMed:10529427, ECO:0000269|PubMed:15656969}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: First expressed at the end of gastrulation (stage
CC       13) in the anterior ectodermal placode. During intermediate neural
CC       plate stages (stages 14-16), expression expands to the presumptive
CC       nasal ectoderm (PNE) and the presumptive lens ectoderm (PLE). By stages
CC       18-21, expression begins to deplete in the PNE, while intensifying in
CC       the PLE so that by late neural stages (stages 22), expression is
CC       restricted to the PLE. Throughout tailbud stages (stage 23-31),
CC       expression is maintained in the lens placode and lens vesicle. In the
CC       maturing lens (stage 32-onwards), expression is restricted to the
CC       anterior lens epithelium, where it remains during the tadpole stage. In
CC       tadpoles there is additional expression in the ventral midline of the
CC       pharynx. Expression continues in the adult eye.
CC       {ECO:0000269|PubMed:10529427}.
CC   -!- INDUCTION: By pax6. {ECO:0000269|PubMed:10529427}.
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DR   EMBL; AF186464; AAF20385.1; -; mRNA.
DR   RefSeq; NP_001079202.1; NM_001085733.2.
DR   AlphaFoldDB; Q9PTK2; -.
DR   SMR; Q9PTK2; -.
DR   PRIDE; Q9PTK2; -.
DR   GeneID; 373809; -.
DR   KEGG; xla:373809; -.
DR   CTD; 373809; -.
DR   Xenbase; XB-GENE-865391; foxe3.L.
DR   OrthoDB; 1270467at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 373809; Expressed in camera-type eye and 1 other tissue.
DR   GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; NAS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0002088; P:lens development in camera-type eye; IMP:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..365
FT                   /note="Forkhead box protein E4"
FT                   /id="PRO_0000258000"
FT   DNA_BIND        48..142
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   365 AA;  40397 MW;  66A1E9AAC697578B CRC64;
     MDSPDSVRVK CESKGSCSPE EGLNNGLPEE HNQASGGRRR KRPVQRGKPP YSYIALIAMA
     IANSPERKLT LGGIYKFIME RFPFYRENSK KWQNSIRHNL TLNDCFVKIP REPGHPGKGN
     YWTLDPAAED MFDNGSFLRR RKRFKRTDIT TYPGYMQNSS AFTPTPTGRA SYPNSIYSSV
     GSGYNPQIHQ THHPAVVHQY YQSPGEAGQG QHRMFSIDSL INQQSLMQPS PGAELTHHSL
     GLNGNLGNMT NSCSVGDLSC FQTQSISPTG VGSLLNRSSN AVSSNLTYSY SSSPPHLPVP
     PASYSPNNSQ LYGSTSRLAM RSGPCVDHTD QLLSLPGTQI NGVCQYNNSS YMRQTHFASG
     LERYM