ID   FOXF1_XENTR             Reviewed;         373 AA.
AC   Q28BS5;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Forkhead box protein F1;
DE            Short=FoxF1;
GN   Name=foxf1 {ECO:0000312|EMBL:CAJ83103.1}; ORFNames=TNeu093i16.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:CAJ83103.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula {ECO:0000312|EMBL:CAJ83103.1};
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable transcription factor. Required for smooth muscle
CC       (visceral mesoderm) differentiation during gut development. Also
CC       required for normal proliferation of the lateral plate mesoderm. Acts
CC       as a downstream mediator of bmp4-signaling (By similarity).
CC       {ECO:0000250|UniProtKB:Q9W707}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
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DR   EMBL; CR942666; CAJ83103.1; -; mRNA.
DR   RefSeq; NP_001039226.1; NM_001045761.1.
DR   AlphaFoldDB; Q28BS5; -.
DR   SMR; Q28BS5; -.
DR   STRING; 8364.ENSXETP00000007706; -.
DR   PaxDb; Q28BS5; -.
DR   DNASU; 734087; -.
DR   GeneID; 734087; -.
DR   KEGG; xtr:734087; -.
DR   CTD; 2294; -.
DR   Xenbase; XB-GENE-478922; foxf1.
DR   eggNOG; KOG2294; Eukaryota.
DR   InParanoid; Q28BS5; -.
DR   OrthoDB; 1120805at2759; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000003565; Expressed in anterior neural ridge (Xenopus) and 27 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR   GO; GO:0030509; P:BMP signaling pathway; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0048566; P:embryonic digestive tract development; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0048745; P:smooth muscle tissue development; ISS:UniProtKB.
DR   GO; GO:0002040; P:sprouting angiogenesis; IEA:Ensembl.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..373
FT                   /note="Forkhead box protein F1"
FT                   /id="PRO_0000259402"
FT   DNA_BIND        54..148
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          1..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          236..255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          283..306
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   373 AA;  40382 MW;  56AF7F8271665D14 CRC64;
     MTAEIQQPPS QPPAQSSPMS AATDKHGGQP SVMESANCAT KTKKTNAGIR RPEKPPYSYI
     ALIVMAIQSS PTKRLTLSEI YQFLQSRFPF FRGSYQGWKN SVRHNLSLNE CFIKLPKGLG
     RPGKGHYWTI DPASEFMFEE GSFRRRPRGF RRKCQALKPM YSMMNGLGFN HIPETYSFQG
     ASGTIACPPN SLSLDSGIGM MNGHLPSNVD GMGLSGHPVS HIAANGGHSY MGSCTGSSGG
     DYSHHDSGSP LLGGGGVMEP HSVYSSPASA WAPSASTPYI KQQPLSPCNS AANPLSSSLS
     SHSLDQSYLH QNSHNTASEL QGIPRYHSQS PSMNDRKEFV FSFNAMASSS MHSGSGSYYH
     QQVGYQDIKP CVM