FOXF2_MOUSE
ID FOXF2_MOUSE Reviewed; 446 AA.
AC O54743; B2RQI5; Q3V1L3; Q78DW1;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Forkhead box protein F2;
DE AltName: Full=Protein LUN;
GN Name=Foxf2; Synonyms=Lun;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], NUCLEOTIDE SEQUENCE [MRNA] OF 11-446,
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=9676429; DOI=10.1006/geno.1998.5288;
RA Miura N., Kakinuma H., Sato M., Aiba N., Terada K., Sugiyama T.;
RT "Mouse forkhead (winged helix) gene LUN encodes a transactivator that acts
RT in the lung.";
RL Genomics 50:346-356(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable transcription activator for a number of lung-
CC specific genes (PubMed:9676429). Mediates up-regulation of the E3
CC ligase IRF2BPL and drives ubiquitination and degradation of CTNNB1 (By
CC similarity). {ECO:0000250|UniProtKB:Q12947,
CC ECO:0000269|PubMed:9676429}.
CC -!- SUBUNIT: Interacts with the transcription factors TBP and TFIIB.
CC {ECO:0000250|UniProtKB:Q12947}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q12947}.
CC -!- TISSUE SPECIFICITY: Uniquely expressed in the bronchiolar epithelium
CC and in type II pneumocytes. {ECO:0000269|PubMed:9676429}.
CC -!- DOMAIN: Two activation domains, AD1 and AD2, C-terminal of (and
CC distinct from) the forkhead domains are necessary for transcriptional
CC activation. {ECO:0000250}.
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DR EMBL; Y12293; CAA72972.1; -; Genomic_DNA.
DR EMBL; Y12294; CAA72972.1; JOINED; Genomic_DNA.
DR EMBL; Y11148; CAA72035.1; -; mRNA.
DR EMBL; AK132385; BAE21137.1; -; mRNA.
DR EMBL; BC137947; AAI37948.1; -; mRNA.
DR EMBL; BC137949; AAI37950.1; -; mRNA.
DR CCDS; CCDS26424.1; -.
DR RefSeq; NP_034355.2; NM_010225.2.
DR AlphaFoldDB; O54743; -.
DR SMR; O54743; -.
DR STRING; 10090.ENSMUSP00000046789; -.
DR PhosphoSitePlus; O54743; -.
DR MaxQB; O54743; -.
DR PaxDb; O54743; -.
DR PeptideAtlas; O54743; -.
DR PRIDE; O54743; -.
DR ProteomicsDB; 271713; -.
DR Antibodypedia; 9203; 241 antibodies from 23 providers.
DR DNASU; 14238; -.
DR Ensembl; ENSMUST00000042054; ENSMUSP00000046789; ENSMUSG00000038402.
DR GeneID; 14238; -.
DR KEGG; mmu:14238; -.
DR UCSC; uc007pzo.2; mouse.
DR CTD; 2295; -.
DR MGI; MGI:1347479; Foxf2.
DR VEuPathDB; HostDB:ENSMUSG00000038402; -.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000162527; -.
DR HOGENOM; CLU_039845_0_0_1; -.
DR InParanoid; O54743; -.
DR OMA; CPVTANG; -.
DR OrthoDB; 1120805at2759; -.
DR PhylomeDB; O54743; -.
DR TreeFam; TF351598; -.
DR BioGRID-ORCS; 14238; 2 hits in 76 CRISPR screens.
DR ChiTaRS; Topors; mouse.
DR PRO; PR:O54743; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; O54743; protein.
DR Bgee; ENSMUSG00000038402; Expressed in brain blood vessel and 192 other tissues.
DR Genevisible; O54743; MM.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0005667; C:transcription regulator complex; ISO:MGI.
DR GO; GO:0003677; F:DNA binding; IDA:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0140296; F:general transcription initiation factor binding; ISO:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0001093; F:TFIIB-class transcription factor binding; ISO:MGI.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0048596; P:embryonic camera-type eye morphogenesis; IMP:BHF-UCL.
DR GO; GO:0048566; P:embryonic digestive tract development; IGI:MGI.
DR GO; GO:0042249; P:establishment of planar polarity of embryonic epithelium; IMP:MGI.
DR GO; GO:0030198; P:extracellular matrix organization; IMP:MGI.
DR GO; GO:0048806; P:genitalia development; ISO:MGI.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:0032434; P:regulation of proteasomal ubiquitin-dependent protein catabolic process; ISO:MGI.
DR GO; GO:1902914; P:regulation of protein polyubiquitination; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060021; P:roof of mouth development; ISO:MGI.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..446
FT /note="Forkhead box protein F2"
FT /id="PRO_0000322981"
FT DNA_BIND 100..194
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 1..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 257..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 340..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 266
FT /note="H -> Q (in Ref. 1; CAA72972/CAA72035)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 446 AA; 46383 MW; 390A03EB325DAAEB CRC64;
MSTEGGPPPP PPRPPPAPLR RACSPAPGAL QAALMSPPPA ATLESTSSSS SSSSASCASS
SSNSVSASAG ACKSAASSGG AGAGSGGTKK ATSGLRRPEK PPYSYIALIV MAIQSSPSKR
LTLSEIYQFL QARFPFFRGA YQGWKNSVRH NLSLNECFIK LPKGLGRPGK GHYWTIDPAS
EFMFEEGSFR RRPRGFRRKC QALKPMYHRV VSGLGFGASL LPQGFDFQAP PSAPLGCHGQ
GGYGGLDMMP AGYDTGAGAP GHAHPHHLHH HHVPHMSPNP GSTYMASCPV PAGPAGVGAA
AGGGGGGGDY GPDSSSSPVP SSPAMASAIE CHSPYTSPAA HWSSPGASPY LKQPPALTPS
SNPAASAGLH PSMSSYSLEQ SYLHQNARED LSVGLPRYQH HSTPVCDRKD FVLNFNGISS
FHPSASGSYY HHHHQSVCQD IKPCVM
