FOXF_CAEEL
ID FOXF_CAEEL Reviewed; 362 AA.
AC P91278;
DT 10-FEB-2021, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 2.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=Forkhead box protein F {ECO:0000305};
DE AltName: Full=FOXF homolog {ECO:0000303|PubMed:20335356};
GN Name=let-381 {ECO:0000312|WormBase:F26B1.7};
GN ORFNames=F26B1.7 {ECO:0000312|WormBase:F26B1.7};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=20335356; DOI=10.1242/dev.048496;
RA Amin N.M., Shi H., Liu J.;
RT "The FoxF/FoxC factor LET-381 directly regulates both cell fate
RT specification and cell differentiation in C. elegans mesoderm
RT development.";
RL Development 137:1451-1460(2010).
CC -!- FUNCTION: Transcription factor that is required for cell fate of
CC coelomocytes which are non-muscle mesodermal cells (PubMed:20335356).
CC Acts in concert with, and by activating expression of, the homeodomain
CC gene ceh-34 (PubMed:20335356). Binds to the sequence motif 5'-
CC ATAAA[T/C]A-3' (PubMed:20335356). {ECO:0000269|PubMed:20335356}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089,
CC ECO:0000269|PubMed:20335356}.
CC -!- DEVELOPMENTAL STAGE: Expression begins during embryogenesis and
CC persists in a small number of cells throughout larval development (at
CC protein level) (PubMed:20335356). Expressed transiently in the
CC postembryonic non-gonadal mesoderm (M lineage), first detected in M.dlp
CC and M.drp as they begin to divide (PubMed:20335356).
CC {ECO:0000269|PubMed:20335356}.
CC -!- DISRUPTION PHENOTYPE: Embryonic lethality; those few animals that
CC survive to adulthood lack functional embryonic and M lineage
CC (mesoblast-cell) derived coelomocytes (CCs) (PubMed:20335356). RNAi-
CC mediated knockdown abolishes expression of ceh-34 in the M lineage
CC (PubMed:20335356). {ECO:0000269|PubMed:20335356}.
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DR EMBL; BX284601; CCD64199.1; -; Genomic_DNA.
DR PIR; T30169; T30169.
DR RefSeq; NP_491826.1; NM_059425.3.
DR AlphaFoldDB; P91278; -.
DR SMR; P91278; -.
DR STRING; 6239.F26B1.7; -.
DR PaxDb; P91278; -.
DR EnsemblMetazoa; F26B1.7.1; F26B1.7.1; WBGene00002601.
DR GeneID; 172331; -.
DR KEGG; cel:CELE_F26B1.7; -.
DR UCSC; F26B1.7; c. elegans.
DR CTD; 172331; -.
DR WormBase; F26B1.7; CE28006; WBGene00002601; let-381.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000173807; -.
DR HOGENOM; CLU_785810_0_0_1; -.
DR InParanoid; P91278; -.
DR OMA; FMDDWRF; -.
DR OrthoDB; 1270467at2759; -.
DR PhylomeDB; P91278; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00002601; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:WormBase.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0007501; P:mesodermal cell fate specification; IMP:WormBase.
DR GO; GO:0002119; P:nematode larval development; IMP:UniProtKB.
DR GO; GO:0048337; P:positive regulation of mesodermal cell fate specification; IGI:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 1: Evidence at protein level;
KW Activator; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..362
FT /note="Forkhead box protein F"
FT /id="PRO_0000451992"
FT DNA_BIND 72..169
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 19..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..70
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 362 AA; 39981 MW; 3033D6E19C93DA87 CRC64;
MECSTAIYSL ANALGPLKLD STAPNNSHRT IKAENYFNED EEDYNENSHE DSEDSKEDSD
GQGCRSRKRK EKPPFSYIAL IAMAISKRPD KKATLAEIYS YLQENFEFFR GEYAGWRNSI
RHNLSLNECF VKLPKDTGES YRGRKGHKWT ISDSCEFMLE ENGFRRRPRG YKARKRTHFP
GVTASNEMGI GGATFDYPSS TTELTDSGTS SLNTDVKNIL LNGGEDFGPS ISDQLVSSTT
SAVLPSLNGP DQSPIYPNYF GYGTAEFPMQ WASPTYDWPY YATPHIGLCS SDFPGISPSP
TVTPQVSPYF YPPAITTASS FMDDWRFGVS SAAVGAYDSS ASFLAAETTA GDVAIPQDLS
DC
