FOXF_DROME
ID FOXF_DROME Reviewed; 676 AA.
AC Q9VS05; Q8T9N0; Q95WV0;
DT 09-JAN-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Forkhead box protein biniou;
DE AltName: Full=Forkhead box protein FoxF;
DE Short=DmFoxF {ECO:0000303|PubMed:11804790};
GN Name=bin; Synonyms=FoxF {ECO:0000303|PubMed:11691840}; ORFNames=CG18647;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAK97051.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC TISSUE=Embryo {ECO:0000269|PubMed:11691840};
RX PubMed=11691840; DOI=10.1101/gad.917101;
RA Zaffran S., Kuchler A., Lee H.H., Frasch M.;
RT "biniou (FoxF), a central component in a regulatory network controlling
RT visceral mesoderm development and midgut morphogenesis in Drosophila.";
RL Genes Dev. 15:2900-2915(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000312|EMBL:ABE73246.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J.,
RA Park S., Wan K., Yu C., Celniker S.;
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000305, ECO:0000312|EMBL:AAK85150.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 13-676, SUBUNIT, SUBCELLULAR LOCATION, AND
RP DEVELOPMENTAL STAGE.
RX PubMed=11804790; DOI=10.1016/s0925-4773(01)00603-7;
RA Perez Sanchez C., Casas-Tinto S., Sanchez L., Rey-Campos J., Granadino B.;
RT "DmFoxF, a novel Drosophila fork head factor expressed in visceral
RT mesoderm.";
RL Mech. Dev. 111:163-166(2002).
RN [6] {ECO:0000305}
RP FUNCTION.
RX PubMed=12175492; DOI=10.1016/s0925-4773(02)00063-1;
RA Zaffran S., Frasch M.;
RT "The beta 3 tubulin gene is a direct target of bagpipe and biniou in the
RT visceral mesoderm of Drosophila.";
RL Mech. Dev. 114:85-93(2002).
RN [7] {ECO:0000305}
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=14523446; DOI=10.1038/nature01916;
RA Lee H.H., Norris A., Weiss J.B., Frasch M.;
RT "Jelly belly protein activates the receptor tyrosine kinase Alk to specify
RT visceral muscle pioneers.";
RL Nature 425:507-512(2003).
RN [8] {ECO:0000305}
RP FUNCTION.
RX PubMed=14718563; DOI=10.1091/mbc.e03-09-0663;
RA Marin M.C., Rodriguez J.R., Ferrus A.;
RT "Transcription of Drosophila troponin I gene is regulated by two conserved,
RT functionally identical, synergistic elements.";
RL Mol. Biol. Cell 15:1185-1196(2004).
RN [9] {ECO:0000305}
RP FUNCTION.
RX PubMed=15750188; DOI=10.1242/dev.01687;
RA Lee H.H., Frasch M.;
RT "Nuclear integration of positive Dpp signals, antagonistic Wg inputs and
RT mesodermal competence factors during Drosophila visceral mesoderm
RT induction.";
RL Development 132:1429-1442(2005).
RN [10] {ECO:0000305}
RP FUNCTION.
RX PubMed=16171793; DOI=10.1016/j.ydbio.2005.08.017;
RA Vining M.S., Bradley P.L., Comeaux C.A., Andrew D.J.;
RT "Organ positioning in Drosophila requires complex tissue-tissue
RT interactions.";
RL Dev. Biol. 287:19-34(2005).
RN [11] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=16987868; DOI=10.1242/dev.02586;
RA Zaffran S., Reim I., Qian L., Lo P.C., Bodmer R., Frasch M.;
RT "Cardioblast-intrinsic Tinman activity controls proper diversification and
RT differentiation of myocardial cells in Drosophila.";
RL Development 133:4073-4083(2006).
RN [12] {ECO:0000305}
RP FUNCTION.
RX PubMed=17511863; DOI=10.1186/1471-213x-7-49;
RA Popichenko D., Sellin J., Bartkuhn M., Paululat A.;
RT "Hand is a direct target of the forkhead transcription factor Biniou during
RT Drosophila visceral mesoderm differentiation.";
RL BMC Dev. Biol. 7:49-49(2007).
RN [13] {ECO:0000305}
RP FUNCTION.
RX PubMed=17908931; DOI=10.1101/gad.437607;
RA Jakobsen J.S., Braun M., Astorga J., Gustafson E.H., Sandmann T.,
RA Karzynski M., Carlsson P., Furlong E.E.;
RT "Temporal ChIP-on-chip reveals Biniou as a universal regulator of the
RT visceral muscle transcriptional network.";
RL Genes Dev. 21:2448-2460(2007).
RN [14] {ECO:0000305}
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=20736287; DOI=10.1242/dev.046573;
RA Ismat A., Schaub C., Reim I., Kirchner K., Schultheis D., Frasch M.;
RT "HLH54F is required for the specification and migration of longitudinal gut
RT muscle founders from the caudal mesoderm of Drosophila.";
RL Development 137:3107-3117(2010).
RN [15] {ECO:0000305}
RP FUNCTION.
RX PubMed=22378636; DOI=10.1242/dev.069005;
RA Zhu X., Ahmad S.M., Aboukhalil A., Busser B.W., Kim Y., Tansey T.R.,
RA Haimovich A., Jeffries N., Bulyk M.L., Michelson A.M.;
RT "Differential regulation of mesodermal gene expression by Drosophila cell
RT type-specific Forkhead transcription factors.";
RL Development 139:1457-1466(2012).
CC -!- FUNCTION: Component of a regulatory network controlling visceral
CC mesoderm development and midgut morphogenesis. Transcriptional
CC regulator involved in the activation of a large number of genes in the
CC visceral mesoderm including betaTub60D, dpp and Hand. Binds to and
CC regulates a number of enhancers driving expression in the visceral
CC mesoderm in a temporally and spatially restricted manner. Also to binds
CC to enhancers cooperatively with activators, such as bap or HLH54F, to
CC coregulate expression of shared target genes in the visceral mesoderm.
CC Binds to the Ndg enhancer and drives expression of Ndg in the late
CC visceral musculature. May be involved in the transcriptional regulation
CC of wupA in the visceral mesoderm. Plays an indirect role in the later
CC stages of salivary gland positioning. {ECO:0000269|PubMed:11691840,
CC ECO:0000269|PubMed:12175492, ECO:0000269|PubMed:14718563,
CC ECO:0000269|PubMed:15750188, ECO:0000269|PubMed:16171793,
CC ECO:0000269|PubMed:17511863, ECO:0000269|PubMed:17908931,
CC ECO:0000269|PubMed:20736287, ECO:0000269|PubMed:22378636}.
CC -!- SUBUNIT: Binds to DNA. {ECO:0000269|PubMed:11804790}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089,
CC ECO:0000269|PubMed:11804790, ECO:0000269|PubMed:14523446}.
CC -!- TISSUE SPECIFICITY: In embryo, expressed in all types of visceral
CC muscles and their progenitors (at protein level). In late stage 10
CC embryo, expressed in the caudal visceral mesoderm and trunk and hindgut
CC visceral mesoderm progenitors. {ECO:0000269|PubMed:11691840,
CC ECO:0000269|PubMed:14523446, ECO:0000269|PubMed:16987868,
CC ECO:0000269|PubMed:20736287}.
CC -!- DEVELOPMENTAL STAGE: First detected at E10, when it is expressed in
CC progenitors of all three types of visceral musculature including in
CC primordia of the circular midgut muscles, in foregut and hindgut
CC visceral mesoderm primordia and in the caudal visceral mesoderm. At
CC E10-E11, it is detected in nuclei of cells of the presumptive visceral
CC mesoderm. At E12, expression persists in trunk and hindgut visceral
CC mesoderm. By E14, expressed in both circular and longitudinal
CC precursors of midgut muscles, and by E16, expressed in foregut, midgut
CC and hindgut visceral muscles (at protein level). First detected at the
CC embryonic syncytial blastoderm stage. {ECO:0000269|PubMed:11691840,
CC ECO:0000269|PubMed:11804790}.
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DR EMBL; AF292388; AAK97051.1; -; mRNA.
DR EMBL; AE014296; AAF50625.2; -; Genomic_DNA.
DR EMBL; BT025075; ABE73246.1; -; mRNA.
DR EMBL; AY044243; AAK85150.1; -; mRNA.
DR RefSeq; NP_523950.2; NM_079226.3.
DR AlphaFoldDB; Q9VS05; -.
DR SMR; Q9VS05; -.
DR BioGRID; 64215; 11.
DR IntAct; Q9VS05; 8.
DR STRING; 7227.FBpp0076609; -.
DR PaxDb; Q9VS05; -.
DR DNASU; 38766; -.
DR EnsemblMetazoa; FBtr0076900; FBpp0076609; FBgn0045759.
DR GeneID; 38766; -.
DR KEGG; dme:Dmel_CG18647; -.
DR UCSC; CG18647-RA; d. melanogaster.
DR CTD; 38766; -.
DR FlyBase; FBgn0045759; bin.
DR VEuPathDB; VectorBase:FBgn0045759; -.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000173807; -.
DR HOGENOM; CLU_404541_0_0_1; -.
DR InParanoid; Q9VS05; -.
DR OMA; DNANFYA; -.
DR OrthoDB; 686550at2759; -.
DR PhylomeDB; Q9VS05; -.
DR SignaLink; Q9VS05; -.
DR BioGRID-ORCS; 38766; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 38766; -.
DR PRO; PR:Q9VS05; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0045759; Expressed in visceral muscle primordium (Drosophila) and 16 other tissues.
DR Genevisible; Q9VS05; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IGI:FlyBase.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:FlyBase.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0001710; P:mesodermal cell fate commitment; IMP:FlyBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:FlyBase.
DR GO; GO:0007435; P:salivary gland morphogenesis; IMP:FlyBase.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..676
FT /note="Forkhead box protein biniou"
FT /id="PRO_0000420793"
FT DNA_BIND 311..408
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 22..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 131..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..46
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..302
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..608
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 7
FT /note="A -> V (in Ref. 1; AAK97051)"
FT /evidence="ECO:0000305"
FT CONFLICT 38
FT /note="S -> T (in Ref. 1; AAK97051)"
FT /evidence="ECO:0000305"
FT CONFLICT 156
FT /note="A -> V (in Ref. 1; AAK97051)"
FT /evidence="ECO:0000305"
FT CONFLICT 211
FT /note="P -> S (in Ref. 1; AAK97051)"
FT /evidence="ECO:0000305"
FT CONFLICT 275
FT /note="E -> D (in Ref. 1; AAK97051)"
FT /evidence="ECO:0000305"
FT CONFLICT 508
FT /note="V -> L (in Ref. 1; AAK97051)"
FT /evidence="ECO:0000305"
FT CONFLICT 536
FT /note="G -> E (in Ref. 1; AAK97051)"
FT /evidence="ECO:0000305"
FT CONFLICT 606
FT /note="P -> T (in Ref. 1; AAK97051)"
FT /evidence="ECO:0000305"
FT CONFLICT 648
FT /note="A -> V (in Ref. 1; AAK97051)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 676 AA; 71063 MW; 8280B17C5B065AB9 CRC64;
MIKSEEASDR SVMTMDQLGG YYHDPRAHPP FSHPHAHSHP HQHTHTGHPY RAGNLLTGGN
YQAMGGGESP TELIDEKPNI GYMELKHYMD ATPTATPVSA AQHYSLSALH SMGTPPASSS
PIPPYGVLMT AHSAGSASPQ SNSKTPTDLP QDLQYASSST STAKVQPLQV QLQPLNHQYA
STIKYCSNNT ILSANDYQLL TSQEQAGQQQ PQQLPAQQLQ HSPGGGYMSR ISTSPSQVIS
NAHGMPVLNY SSSSSSPAKS LNGSESSPPS QNHLENKVSG SAVVGTGGSS QQDAPSTPDT
TKKSGTRRPE KPALSYINMI GHAIKESPTG KLTLSEIYAY LQKSYEFFRG PYVGWKNSVR
HNLSLNECFK KLPKGMGVGK PGKGNYWTID ENSAHLFEDE GSLRRRPRGY RSKIKVKPYA
GHANGYYASG YGDAGMDNGN YYASPAFASY DYSAAGATGV SPAGGQGFAD PWNAHAAHSG
SSSVGVGMGV GPLPQYTNIS CLAAGGNVNG SATTPPLAHS ALGMAPSASS SSSPLGAAAT
LQSDYAPTAS LVAAGYSYAT SAGSLDNGLR SISLQQLPGL SSIQHAQAQA QAQAHHHHHQ
HHASHPSHSH QGHGSMHQNH GTSSTTPPPS QSGGSHGIDH SPIDRKPAYL PPISPPPMMV
ALNGGGGYYE GLKYAN
