ID   FOXG1_CERSI             Reviewed;         486 AA.
AC   Q1A1A1;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Forkhead box protein G1;
DE            Short=FoxG1;
GN   Name=FOXG1;
OS   Ceratotherium simum (White rhinoceros) (Square-lipped rhinoceros).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Rhinocerotidae; Ceratotherium.
OX   NCBI_TaxID=9807;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Bredenkamp N., Illing N.;
RT   "Evolutionary evolution of forkhead box G1.";
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription repression factor which plays an important role
CC       in the establishment of the regional subdivision of the developing
CC       brain and in the development of the telencephalon.
CC       {ECO:0000250|UniProtKB:P55316}.
CC   -!- SUBUNIT: Interacts with KDM5B (By similarity). Interacts with GRG6/TLE6
CC       (By similarity). Interacts with TLE1; the interaction is inhibited by
CC       interaction with TLE6/GRG6 (By similarity).
CC       {ECO:0000250|UniProtKB:P55316, ECO:0000250|UniProtKB:Q60987}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
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DR   EMBL; DQ387966; ABD38849.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q1A1A1; -.
DR   BMRB; Q1A1A1; -.
DR   SMR; Q1A1A1; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Nucleus; Proto-oncogene; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..486
FT                   /note="Forkhead box protein G1"
FT                   /id="PRO_0000254885"
FT   DNA_BIND        178..272
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          30..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          246..341
FT                   /note="Required for interaction with TLE6"
FT                   /evidence="ECO:0000250|UniProtKB:Q60987"
FT   REGION          380..403
FT                   /note="Interaction with KDM5B"
FT                   /evidence="ECO:0000250"
FT   REGION          424..452
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..59
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..83
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..112
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        137..177
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   486 AA;  51960 MW;  FDDF8DE578FDF541 CRC64;
     MLDMGDRKEV KMIPKSSFSI NSLVPEAVQS DNHHASHGHH NSHHPQHHHH HHHHHHHPPP
     PAPQPPPPPP PPQQPPPAPQ PSQARGVPAA DDDKGPQQLL LPPPPPPPPA AALDGAKADG
     LGGKGEPGGG PGELAPVGPD EKEKGAGAGG EEKKGAGEGG KDGEGGKEGE KKNGKYEKPP
     FSYNALIMMA IRQSPEKRLT LNGIYEFIMK NFPYYRENKQ GWQNSIRHNL SLNKCFVKVP
     RHYDDPGKGN YWMLDPSSDD VFIGGTTGKL RRRSTTSRAK LAFKRGARLT STGLTFMDRA
     GSLYWPMSPF LSLHHPRASS TLSYNGTTSA YPSHPMPYSS VLTQNSLGNN HSFSTANGLS
     VDRLVNGEIP YATHHLTAAA LAASVPCGLS VPCSGTYSLN PCSVNLLAGQ TSYFFPHVPH
     PSMTSQSSTS MSARAASSST SPQAPSTLPC ESLRPSLPSF TTGLSGGLSD YFTHQNQGSS
     SNPLIH