FOXG1_CHICK
ID FOXG1_CHICK Reviewed; 451 AA.
AC Q90964;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Forkhead box protein G1;
DE Short=FoxG1;
DE AltName: Full=Brain factor 1;
DE Short=BF-1;
DE Short=BF1;
DE Short=cBF-1;
DE AltName: Full=CEQ 3-1;
DE AltName: Full=Forkhead-related protein FKHL1;
DE AltName: Full=N-62-5;
DE AltName: Full=Proto-oncogene C-QIN;
GN Name=FOXG1; Synonyms=FKHL1, FOXG1B, QIN;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7831308; DOI=10.1073/pnas.92.2.447;
RA Chang H.W., Li J., Kretzschmar D., Vogt P.K.;
RT "Avian cellular homolog of the qin oncogene.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:447-451(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=White leghorn; TISSUE=Retina;
RX PubMed=8757134; DOI=10.1038/382632a0;
RA Yuasa J., Hirano S., Yamagata M., Noda M.;
RT "Visual projection map specified by topographic expression of transcription
RT factors in the retina.";
RL Nature 382:632-635(1996).
CC -!- FUNCTION: May determine the nasotemporal axis of the retina, and
CC consequently specify the topographical projection of the retinal
CC ganglion-cell axons to the tectum by controlling expression of their
CC target genes.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
CC -!- TISSUE SPECIFICITY: Retina and brain.
CC -!- DEVELOPMENTAL STAGE: Can be detected in regions including primordial
CC retina and neuroepithelium by embryonic day 2 (E2). At E3, expressed in
CC the nasal retina and pigment epithelium as well as in the
CC telencephalon, and at E7 is expressed in retinal ganglion cells. Levels
CC begin to decline from E4 and almost disappear by E10.
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DR EMBL; L36814; AAA66954.1; -; mRNA.
DR EMBL; U47275; AAB08466.1; -; mRNA.
DR PIR; A55909; A55909.
DR RefSeq; NP_990524.1; NM_205193.1.
DR AlphaFoldDB; Q90964; -.
DR SMR; Q90964; -.
DR BioGRID; 676376; 1.
DR STRING; 9031.ENSGALP00000015999; -.
DR PaxDb; Q90964; -.
DR Ensembl; ENSGALT00000065608; ENSGALP00000054672; ENSGALG00000036364.
DR GeneID; 396110; -.
DR KEGG; gga:396110; -.
DR CTD; 2290; -.
DR VEuPathDB; HostDB:geneid_396110; -.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000160678; -.
DR InParanoid; Q90964; -.
DR OMA; AHPMSYS; -.
DR OrthoDB; 1270467at2759; -.
DR PhylomeDB; Q90964; -.
DR PRO; PR:Q90964; -.
DR Proteomes; UP000000539; Chromosome 5.
DR Bgee; ENSGALG00000036364; Expressed in brain.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0016199; P:axon midline choice point recognition; IEA:Ensembl.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IEA:Ensembl.
DR GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
DR GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0007405; P:neuroblast proliferation; IEA:Ensembl.
DR GO; GO:0048664; P:neuron fate determination; IEA:Ensembl.
DR GO; GO:0045787; P:positive regulation of cell cycle; IEA:Ensembl.
DR GO; GO:0002052; P:positive regulation of neuroblast proliferation; IEA:Ensembl.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0021852; P:pyramidal neuron migration to cerebral cortex; IEA:Ensembl.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Nucleus; Proto-oncogene;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..451
FT /note="Forkhead box protein G1"
FT /id="PRO_0000091839"
FT DNA_BIND 142..233
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 29..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..57
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 451 AA; 48857 MW; E9E5B407D2321B50 CRC64;
MLDMGDRKEV KMLPKSSFSI NSLVPEAVQS DNHSGHSHHN SHHPHHHHHH HHHHPPPPQQ
PQRAAAAEEE DEEKAPLLLP PPAAGALEAA KAEALAGKGE AGAAAAELEE KEKAAEEKKG
AAEGGKDGES GKEGEKKNGK YEKPPFSYNA LIMMAIRQSP EKRLTLNGIY EFIMKNFPYY
RENKQGWQNS IRHNLSLNKC FVKVPRHYDD PGKGNYWMLD PSSDDVFIGG TTGKLRRRST
TSRAKLAFKR GARLTSTGLT FMDRAGSLYW PMSPFLSLHH PRASSTLSYN GTASAYPSHP
MPYSSVLTQN SLGNNHSFST SNGLSVDRLV NGEIPYATHH LTAAALAASV PCGLSVPCSG
TYSLNPCSVN LLAGQTSYFF PHVPHPSMTS QSSTSMTARA ASSSTSPQAP STLPCESLRP
SLPSFTTGLS GGLSDYFTHQ NQGSSSNPLI H
