FOXG1_CHLPG
ID FOXG1_CHLPG Reviewed; 489 AA.
AC Q1A1A5;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 25-MAY-2022, entry version 57.
DE RecName: Full=Forkhead box protein G1;
DE Short=FoxG1;
GN Name=FOXG1;
OS Chlorocebus pygerythrus (Vervet monkey) (Cercopithecus pygerythrus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60710;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Bredenkamp N., Illing N.;
RT "Evolutionary evolution of forkhead box G1.";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription repression factor which plays an important role
CC in the establishment of the regional subdivision of the developing
CC brain and in the development of the telencephalon.
CC {ECO:0000250|UniProtKB:P55316}.
CC -!- SUBUNIT: Interacts with KDM5B (By similarity). Interacts with GRG6/TLE6
CC (By similarity). Interacts with TLE1; the interaction is inhibited by
CC interaction with TLE6/GRG6 (By similarity).
CC {ECO:0000250|UniProtKB:P55316, ECO:0000250|UniProtKB:Q60987}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
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DR EMBL; DQ387962; ABD38845.1; -; Genomic_DNA.
DR AlphaFoldDB; Q1A1A5; -.
DR SMR; Q1A1A5; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Nucleus; Proto-oncogene; Transcription;
KW Transcription regulation.
FT CHAIN 1..489
FT /note="Forkhead box protein G1"
FT /id="PRO_0000254884"
FT DNA_BIND 181..275
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 31..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..344
FT /note="Required for interaction with TLE6"
FT /evidence="ECO:0000250|UniProtKB:Q60987"
FT REGION 383..406
FT /note="Interaction with KDM5B"
FT /evidence="ECO:0000250"
FT REGION 427..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..59
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..87
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..115
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 489 AA; 52321 MW; 0329B0CBE087EB3A CRC64;
MLDMGDRKEV KMIPKSSFSI NSLVPEAVQN DNHHASHGHH NSHHPQHHHH HHHHHHHPPP
PAPQPPPPPQ QQPPPPPPPP APQPPQTRGA PAADDDKGPQ QLLLPPPPPP PPAAALDGAK
ADGLGGKGEP GGGPGELAPV GPDEKEKGAG AGGEEKKGAG EGGKDGEGGK EGEKKNGKYE
KPPFSYNALI MMAIRQSPEK RLTLNGIYEF IMKNFPYYRE NKQGWQNSIR HNLSLNKCFV
KVPRHYDDPG KGNYWMLDPS SDDVFIGGTT GKLRRRSTTS RAKLAFKRGA RLTSTGLTFM
DRAGSLYWPM SPFLSLHHPR ASSTLSYNGT TSAYPSHPMP YSSVLTQNSL GNNHSFSTAN
GLSVDRLVNG EIPYATHHLT AAALAASVPC GLSVPCSGTY SLNPCSVNLL AGQTSYFFPH
VPHPSMTSQS STSMSARAAS SSTSPQAPST LPCESLRPSL PSFTTGLSGG LSDYFTHQNQ
GSSSNPLIH
