ID   FOXG1_EPOGA             Reviewed;         485 AA.
AC   Q1A1A3;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Forkhead box protein G1;
DE            Short=FoxG1;
GN   Name=FOXG1;
OS   Epomophorus gambianus (Gambian epauletted fruit bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC   Pteropodinae; Epomophorini-Myonycterini lineage; Epomophorini; Epomophorus.
OX   NCBI_TaxID=372077;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Bredenkamp N., Illing N.;
RT   "Evolutionary evolution of forkhead box G1.";
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription repression factor which plays an important role
CC       in the establishment of the regional subdivision of the developing
CC       brain and in the development of the telencephalon.
CC       {ECO:0000250|UniProtKB:P55316}.
CC   -!- SUBUNIT: Interacts with KDM5B (By similarity). Interacts with GRG6/TLE6
CC       (By similarity). Interacts with TLE1; the interaction is inhibited by
CC       interaction with TLE6/GRG6 (By similarity).
CC       {ECO:0000250|UniProtKB:P55316, ECO:0000250|UniProtKB:Q60987}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
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DR   EMBL; DQ387964; ABD38847.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q1A1A3; -.
DR   SMR; Q1A1A3; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Nucleus; Proto-oncogene; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..485
FT                   /note="Forkhead box protein G1"
FT                   /id="PRO_0000254886"
FT   DNA_BIND        177..271
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          31..177
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          245..340
FT                   /note="Required for interaction with TLE6"
FT                   /evidence="ECO:0000250|UniProtKB:Q60987"
FT   REGION          379..402
FT                   /note="Interaction with KDM5B"
FT                   /evidence="ECO:0000250"
FT   REGION          423..451
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..58
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..83
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        136..176
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   485 AA;  51854 MW;  497B60335A93857C CRC64;
     MLDMGDRKEV KMIPKSSFSI NSLVPEAVQN DNHHASHGHH NSHHPQHHHH HHHHHHPPPP
     APQPPPPPQQ QPPPPPQAPQ PPQARGAPAA DDDKGPQQLL LPPPPPPAAA LDGAKADGLG
     GKGEPGGGGP GELAPVGPDE KEKGAGAGGE EKKGAGEGGK DGEGGKEGEK KNGKYEKPPF
     SYNALIMMAI RQSPEKRLTL NGIYEFIMKN FPYYRENKQG WQNSIRHNLS LNKCFVKVPR
     HYDDPGKGNY WMLDPSSDDV FIGGTTGKLR RRSTTSRAKL AFKRGARLTS TGLTFMDRAG
     SLYWPMSPFL SLHHPRASST LSYNGTTSAY PSHPMPYSSV LTQNSLGNNH SFSTANGLSV
     DRLVNGEIPY ATHHLTAAAL AASVPCGLSV PCSGTYSLNP CSVNLLAGQT SYFFPHVPHP
     SMTSQSSTSM SARAASSSTS PQAPSTLPCE SLRPSLPSFT TGLSGGLSDY FTHQNQGSSS
     NPLIH