ID   FOXG1_EQUQB             Reviewed;         488 AA.
AC   Q1A1A2;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Forkhead box protein G1;
DE            Short=FoxG1;
GN   Name=FOXG1;
OS   Equus quagga burchellii (Plains zebra) (Equus burchelli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus; Equus quagga.
OX   NCBI_TaxID=89252;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Bredenkamp N., Illing N.;
RT   "Evolutionary evolution of forkhead box G1.";
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription repression factor which plays an important role
CC       in the establishment of the regional subdivision of the developing
CC       brain and in the development of the telencephalon.
CC       {ECO:0000250|UniProtKB:P55316}.
CC   -!- SUBUNIT: Interacts with KDM5B (By similarity). Interacts with GRG6/TLE6
CC       (By similarity). Interacts with TLE1; the interaction is inhibited by
CC       interaction with TLE6/GRG6 (By similarity).
CC       {ECO:0000250|UniProtKB:P55316, ECO:0000250|UniProtKB:Q60987}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
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DR   EMBL; DQ387965; ABD38848.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q1A1A2; -.
DR   BMRB; Q1A1A2; -.
DR   SMR; Q1A1A2; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Nucleus; Proto-oncogene; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..488
FT                   /note="Forkhead box protein G1"
FT                   /id="PRO_0000254887"
FT   DNA_BIND        180..274
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          31..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          248..343
FT                   /note="Required for interaction with TLE6"
FT                   /evidence="ECO:0000250|UniProtKB:Q60987"
FT   REGION          382..405
FT                   /note="Interaction with KDM5B"
FT                   /evidence="ECO:0000250"
FT   REGION          426..454
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..59
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..83
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..113
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        139..179
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   488 AA;  52274 MW;  5BCA611EECA85980 CRC64;
     MLDMGDRKEV KMIPKSSFSI NSLVPEAVQN DNHHASHGHH NSHHPQHHHH HHHHHHHPPP
     PAPQPPPPPQ QQPPPPPQAP QPSQARGVPA ADDDKGPQQL LLPPPPPPQP PAAALDGAKA
     DGLGGKGEPG GGPGELAPVG PDEKEKGAGA GGEEKKGAGE GGKDGEGGKE GEKKNGKYEK
     PPFSYNALIM MAIRQSPEKR LTLNGIYEFI MKNFPYYREN KQGWQNSIRH NLSLNKCFVK
     VPRHYDDPGK GNYWMLDPSS DDVFIGGTTG KLRRRSTTSR AKLAFKRGAR LTSTGLTFMD
     RAGSLYWPMS PFLSLHHPRA SSTLSYNGTT SAYPSHPMPY SSVLTQNSLG NNHSFSTANG
     LSVDRLVNGE IPYATHHLTA AALAASVPCG LSVPCSGTYS LNPCSVNLLA GQTSYFFPHV
     PHPSMTSQSS TSMSARAASS STSPQAPSTL PCESLRPSLP SFTTGLSGGL SDYFTHQNQG
     SSSNPLIH