FOXG1_HUMAN
ID FOXG1_HUMAN Reviewed; 489 AA.
AC P55316; A6NFY2; P55315; Q14488; Q86XT7;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 180.
DE RecName: Full=Forkhead box protein G1;
DE AltName: Full=Brain factor 1;
DE Short=BF-1;
DE Short=BF1;
DE AltName: Full=Brain factor 2;
DE Short=BF-2;
DE Short=BF2;
DE Short=hBF-2;
DE AltName: Full=Forkhead box protein G1A;
DE AltName: Full=Forkhead box protein G1B;
DE AltName: Full=Forkhead box protein G1C;
DE AltName: Full=Forkhead-related protein FKHL1;
DE Short=HFK1;
DE AltName: Full=Forkhead-related protein FKHL2;
DE Short=HFK2;
DE AltName: Full=Forkhead-related protein FKHL3;
DE Short=HFK3;
GN Name=FOXG1;
GN Synonyms=FKH2, FKHL1, FKHL2, FKHL3, FKHL4, FOXG1A, FOXG1B, FOXG1C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Fetal brain;
RX PubMed=7959731; DOI=10.1006/geno.1994.1313;
RA Murphy D.B., Wiese S., Burfeind P., Schmundt D., Mattei M.-G.,
RA Schulz-Schaeffer W., Thies U.;
RT "Human brain factor 1, a new member of the fork head gene family.";
RL Genomics 21:551-557(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7599184; DOI=10.1016/0167-4781(95)00059-p;
RA Wiese S., Murphy D.B., Schlung A., Burfeind P., Schmundt D., Schnulle V.,
RA Mattei M.-G., Thies U.;
RT "The genes for human brain factor 1 and 2, members of the fork head gene
RT family, are clustered on chromosome 14q.";
RL Biochim. Biophys. Acta 1262:105-112(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP INTERACTION WITH KDM5B, MUTAGENESIS OF 388-VAL-PRO-389; 394-VAL-PRO-395 AND
RP PRO-404, AND FUNCTION.
RX PubMed=12657635; DOI=10.1074/jbc.m301994200;
RA Tan K., Shaw A.L., Madsen B., Jensen K., Taylor-Papadimitriou J.,
RA Freemont P.S.;
RT "Human PLU-1 has transcriptional repression properties and interacts with
RT the developmental transcription factors BF-1 and PAX9.";
RL J. Biol. Chem. 278:20507-20513(2003).
RN [7]
RP IDENTIFICATION OF FOXG1 AS A SINGLE-COPY GENE.
RX PubMed=17260156; DOI=10.1007/s00427-006-0128-x;
RA Bredenkamp N., Seoighe C., Illing N.;
RT "Comparative evolutionary analysis of the FoxG1 transcription factor from
RT diverse vertebrates identifies conserved recognition sites for microRNA
RT regulation.";
RL Dev. Genes Evol. 217:227-233(2007).
RN [8]
RP SUBCELLULAR LOCATION, VARIANT RTTCV CYS-244, VARIANT LEU-109, AND
RP CHARACTERIZATION OF VARIANT RTTCV CYS-244.
RX PubMed=21280142; DOI=10.1002/humu.21422;
RA Guen T.L., Fichou Y., Nectoux J., Bahi-Buisson N., Rivier F., Boddaert N.,
RA Diebold B., Heron D., Chelly J., Bienvenu T.;
RT "A missense mutation within the fork-head domain of the forkhead box G1
RT Gene (FOXG1) affects its nuclear localization.";
RL Hum. Mutat. 32:E2026-E2035(2011).
RN [9]
RP VARIANT RTTCV LEU-215.
RX PubMed=19578037; DOI=10.1136/jmg.2009.067884;
RA Mencarelli M.A., Spanhol-Rosseto A., Artuso R., Rondinella D.,
RA De Filippis R., Bahi-Buisson N., Nectoux J., Rubinsztajn R., Bienvenu T.,
RA Moncla A., Chabrol B., Villard L., Krumina Z., Armstrong J., Roche A.,
RA Pineda M., Gak E., Mari F., Ariani F., Renieri A.;
RT "Novel FOXG1 mutations associated with the congenital variant of Rett
RT syndrome.";
RL J. Med. Genet. 47:49-53(2010).
RN [10]
RP VARIANTS ARG-191 AND SER-232, AND VARIANTS RTTCV 217-TYR--HIS-489 DEL AND
RP 396-CYS--HIS-489 DEL.
RX PubMed=26993267; DOI=10.1136/jmedgenet-2015-103263;
RA Trump N., McTague A., Brittain H., Papandreou A., Meyer E., Ngoh A.,
RA Palmer R., Morrogh D., Boustred C., Hurst J.A., Jenkins L., Kurian M.A.,
RA Scott R.H.;
RT "Improving diagnosis and broadening the phenotypes in early-onset seizure
RT and severe developmental delay disorders through gene panel analysis.";
RL J. Med. Genet. 53:310-317(2016).
CC -!- FUNCTION: Transcription repression factor which plays an important role
CC in the establishment of the regional subdivision of the developing
CC brain and in the development of the telencephalon.
CC {ECO:0000269|PubMed:12657635}.
CC -!- SUBUNIT: Interacts with KDM5B (PubMed:12657635). Interacts with
CC GRG6/TLE6 (By similarity). Interacts with TLE1; the interaction is
CC inhibited by interaction with TLE6/GRG6 (By similarity).
CC {ECO:0000250|UniProtKB:Q60987, ECO:0000269|PubMed:12657635}.
CC -!- INTERACTION:
CC P55316; Q04724: TLE1; NbExp=2; IntAct=EBI-715416, EBI-711424;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089,
CC ECO:0000269|PubMed:21280142}.
CC -!- TISSUE SPECIFICITY: Expression is restricted to the neurons of the
CC developing telencephalon. {ECO:0000269|PubMed:7959731}.
CC -!- DISEASE: Rett syndrome congenital variant (RTTCV) [MIM:613454]: A
CC severe neurodevelopmental disorder with features of classic Rett
CC syndrome but earlier onset in the first months of life. Clinical
CC features include progressive microcephaly, hypotonia, irresponsiveness
CC and irritability in the neonatal period, intellectual disability,
CC psychomotor regression and stereotypical movements.
CC {ECO:0000269|PubMed:19578037, ECO:0000269|PubMed:21280142,
CC ECO:0000269|PubMed:26993267}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- CAUTION: PubMed:7959731 claims that there are 3 different FOXG1
CC proteins, FOXG1A, FOXG1B, and FOXG1C. It was latter found that there is
CC only one gene and the differences between these three may be sequencing
CC errors since the protein is coded in a unique exon. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Wikipedia; Note=FOXG1 entry;
CC URL="https://en.wikipedia.org/wiki/FOXG1";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X74142; CAA52239.1; -; mRNA.
DR EMBL; X74143; CAA52240.1; -; mRNA.
DR EMBL; X74144; CAA52241.1; -; mRNA.
DR EMBL; X78202; CAA55038.1; -; Genomic_DNA.
DR EMBL; AL049777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471078; EAW65978.1; -; Genomic_DNA.
DR EMBL; BC050072; AAH50072.1; -; mRNA.
DR CCDS; CCDS9636.1; -.
DR PIR; B54743; B54743.
DR PIR; I37451; I37451.
DR RefSeq; NP_005240.3; NM_005249.4.
DR PDB; 7CBY; X-ray; 1.65 A; C=178-281.
DR PDBsum; 7CBY; -.
DR AlphaFoldDB; P55316; -.
DR BMRB; P55316; -.
DR SMR; P55316; -.
DR BioGRID; 108580; 84.
DR CORUM; P55316; -.
DR IntAct; P55316; 66.
DR MINT; P55316; -.
DR STRING; 9606.ENSP00000339004; -.
DR iPTMnet; P55316; -.
DR PhosphoSitePlus; P55316; -.
DR BioMuta; FOXG1; -.
DR DMDM; 152031604; -.
DR MassIVE; P55316; -.
DR MaxQB; P55316; -.
DR PaxDb; P55316; -.
DR PeptideAtlas; P55316; -.
DR PRIDE; P55316; -.
DR ProteomicsDB; 56844; -.
DR Antibodypedia; 9316; 298 antibodies from 33 providers.
DR DNASU; 2290; -.
DR Ensembl; ENST00000313071.7; ENSP00000339004.3; ENSG00000176165.12.
DR GeneID; 2290; -.
DR KEGG; hsa:2290; -.
DR MANE-Select; ENST00000313071.7; ENSP00000339004.3; NM_005249.5; NP_005240.3.
DR UCSC; uc001wqe.5; human.
DR CTD; 2290; -.
DR DisGeNET; 2290; -.
DR GeneCards; FOXG1; -.
DR HGNC; HGNC:3811; FOXG1.
DR HPA; ENSG00000176165; Tissue enriched (brain).
DR MalaCards; FOXG1; -.
DR MIM; 164874; gene.
DR MIM; 613454; phenotype.
DR neXtProt; NX_P55316; -.
DR OpenTargets; ENSG00000176165; -.
DR Orphanet; 261229; 14q11.2 microduplication syndrome.
DR Orphanet; 261144; FOXG1 syndrome due to 14q12 microdeletion.
DR PharmGKB; PA162388806; -.
DR VEuPathDB; HostDB:ENSG00000176165; -.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000160678; -.
DR HOGENOM; CLU_040357_1_0_1; -.
DR InParanoid; P55316; -.
DR OMA; AHPMSYS; -.
DR OrthoDB; 1270467at2759; -.
DR PhylomeDB; P55316; -.
DR TreeFam; TF316127; -.
DR PathwayCommons; P55316; -.
DR Reactome; R-HSA-9022692; Regulation of MECP2 expression and activity.
DR Reactome; R-HSA-9617828; FOXO-mediated transcription of cell cycle genes.
DR SignaLink; P55316; -.
DR SIGNOR; P55316; -.
DR BioGRID-ORCS; 2290; 14 hits in 1099 CRISPR screens.
DR ChiTaRS; FOXG1; human.
DR GeneWiki; FOXG1; -.
DR GenomeRNAi; 2290; -.
DR Pharos; P55316; Tbio.
DR PRO; PR:P55316; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; P55316; protein.
DR Bgee; ENSG00000176165; Expressed in cortical plate and 72 other tissues.
DR Genevisible; P55316; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; TAS:ProtInc.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0007568; P:aging; IEA:Ensembl.
DR GO; GO:0016199; P:axon midline choice point recognition; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; TAS:ProtInc.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IEA:Ensembl.
DR GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
DR GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0007405; P:neuroblast proliferation; IEA:Ensembl.
DR GO; GO:0048664; P:neuron fate determination; IEA:Ensembl.
DR GO; GO:0045787; P:positive regulation of cell cycle; IEA:Ensembl.
DR GO; GO:0002052; P:positive regulation of neuroblast proliferation; IEA:Ensembl.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0021852; P:pyramidal neuron migration to cerebral cortex; IEA:Ensembl.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Developmental protein; Disease variant; DNA-binding;
KW Intellectual disability; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..489
FT /note="Forkhead box protein G1"
FT /id="PRO_0000091835"
FT DNA_BIND 181..275
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 31..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..344
FT /note="Required for interaction with TLE6"
FT /evidence="ECO:0000250|UniProtKB:Q60987"
FT REGION 383..406
FT /note="Interaction with KDM5B"
FT /evidence="ECO:0000269|PubMed:12657635"
FT REGION 427..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..59
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..87
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..115
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 109
FT /note="P -> L (in dbSNP:rs398124203)"
FT /evidence="ECO:0000269|PubMed:21280142"
FT /id="VAR_064395"
FT VARIANT 191
FT /note="M -> R (found in a patient with developmental delay
FT with seizures and mild developmental delay; unknown
FT pathological significance)"
FT /evidence="ECO:0000269|PubMed:26993267"
FT /id="VAR_078715"
FT VARIANT 215
FT /note="F -> L (in RTTCV; dbSNP:rs267606828)"
FT /evidence="ECO:0000269|PubMed:19578037"
FT /id="VAR_063885"
FT VARIANT 217..489
FT /note="Missing (in RTTCV)"
FT /evidence="ECO:0000269|PubMed:26993267"
FT /id="VAR_078716"
FT VARIANT 232
FT /note="N -> S (probable disease-associated variant found in
FT a patient with developmental delay)"
FT /evidence="ECO:0000269|PubMed:26993267"
FT /id="VAR_078717"
FT VARIANT 244
FT /note="R -> C (in RTTCV; the mutant protein extensively,
FT although not fully, localizes in nuclear speckles, while
FT the wild-type is more widely dispersed throughout the
FT nucleus; dbSNP:rs786205009)"
FT /evidence="ECO:0000269|PubMed:21280142"
FT /id="VAR_064396"
FT VARIANT 396..489
FT /note="Missing (in RTTCV)"
FT /evidence="ECO:0000269|PubMed:26993267"
FT /id="VAR_078718"
FT MUTAGEN 388..389
FT /note="VP->AA: Abolishes interaction with KDM5B."
FT /evidence="ECO:0000269|PubMed:12657635"
FT MUTAGEN 394..395
FT /note="VP->AA: Abolishes interaction with KDM5B."
FT /evidence="ECO:0000269|PubMed:12657635"
FT MUTAGEN 404
FT /note="P->A: Abolishes interaction with KDM5B."
FT /evidence="ECO:0000269|PubMed:12657635"
FT CONFLICT 27..28
FT /note="AV -> GL (in Ref. 1; CAA52239/CAA52240 and 2;
FT CAA55038)"
FT /evidence="ECO:0000305"
FT CONFLICT 69..75
FT /note="PQQQQPP -> RAAQQQQ (in Ref. 1; CAA52239)"
FT /evidence="ECO:0000305"
FT CONFLICT 79..138
FT /note="PPAPQPPQTRGAPAADDDKGPQQLLLPPPPPPPPAAALDGAKADGLGGKGEP
FT GGGPGELA -> RRGARRRRRRGPSSCCSAAHAHGAPEGQRQLAQGDRRGRGIC (in
FT Ref. 1; CAA52240 and 2; CAA55038)"
FT /evidence="ECO:0000305"
FT CONFLICT 81..96
FT /note="APQPPQTRGAPAADDD -> LAPQAGGAAQSNDE (in Ref. 1;
FT CAA52239)"
FT /evidence="ECO:0000305"
FT CONFLICT 101
FT /note="Q -> L (in Ref. 1; CAA52239)"
FT /evidence="ECO:0000305"
FT CONFLICT 107..117
FT /note="PPPPPPAAALD -> TDHHRPPS (in Ref. 1; CAA52239)"
FT /evidence="ECO:0000305"
FT CONFLICT 122..133
FT /note="DGLGGKGEPGGG -> GGCCR (in Ref. 1; CAA52239)"
FT /evidence="ECO:0000305"
FT CONFLICT 122
FT /note="D -> V (in Ref. 5; AAH50072)"
FT /evidence="ECO:0000305"
FT CONFLICT 138
FT /note="A -> G (in Ref. 1; CAA52239)"
FT /evidence="ECO:0000305"
FT CONFLICT 148..150
FT /note="GAG -> AR (in Ref. 1; CAA52240 and 2; CAA55038)"
FT /evidence="ECO:0000305"
FT CONFLICT 183
FT /note="P -> PP (in Ref. 1; CAA52241)"
FT /evidence="ECO:0000305"
FT CONFLICT 194
FT /note="I -> M (in Ref. 1; CAA52240 and 2; CAA55038)"
FT /evidence="ECO:0000305"
FT CONFLICT 226
FT /note="Q -> H (in Ref. 1; CAA52241)"
FT /evidence="ECO:0000305"
FT CONFLICT 231
FT /note="H -> D (in Ref. 1; CAA52241)"
FT /evidence="ECO:0000305"
FT CONFLICT 237
FT /note="K -> M (in Ref. 5; AAH50072)"
FT /evidence="ECO:0000305"
FT CONFLICT 274
FT /note="Missing (in Ref. 1; CAA52240 and 2; CAA55038)"
FT /evidence="ECO:0000305"
FT CONFLICT 276
FT /note="Missing (in Ref. 1; CAA52240 and 2; CAA55038)"
FT /evidence="ECO:0000305"
FT CONFLICT 281
FT /note="R -> P (in Ref. 1; CAA52239/CAA52240 and 2;
FT CAA55038)"
FT /evidence="ECO:0000305"
FT CONFLICT 284
FT /note="L -> P (in Ref. 1; CAA52240 and 2; CAA55038)"
FT /evidence="ECO:0000305"
FT CONFLICT 286..291
FT /note="FKRGAR -> AFRWCA (in Ref. 1; CAA52241)"
FT /evidence="ECO:0000305"
FT CONFLICT 291
FT /note="R -> A (in Ref. 1; CAA52239/CAA52240 and 2;
FT CAA55038)"
FT /evidence="ECO:0000305"
FT CONFLICT 302..320
FT /note="RAGSLYWPMSPFLSLHHPR -> APAPSTGPCRPSCPCTTP (in Ref.
FT 1; CAA52240 and 2; CAA55038)"
FT /evidence="ECO:0000305"
FT CONFLICT 356
FT /note="F -> S (in Ref. 1; CAA52240 and 2; CAA55038)"
FT /evidence="ECO:0000305"
FT CONFLICT 371
FT /note="E -> G (in Ref. 1; CAA52240 and 2; CAA55038)"
FT /evidence="ECO:0000305"
FT CONFLICT 385
FT /note="A -> T (in Ref. 1; CAA52240 and 2; CAA55038)"
FT /evidence="ECO:0000305"
FT CONFLICT 393
FT /note="S -> L (in Ref. 1; CAA52240 and 2; CAA55038)"
FT /evidence="ECO:0000305"
FT CONFLICT 439
FT /note="A -> T (in Ref. 5; AAH50072)"
FT /evidence="ECO:0000305"
FT CONFLICT 446..450
FT /note="QAPST -> AGPPRP (in Ref. 1; CAA52240 and 2;
FT CAA55038)"
FT /evidence="ECO:0000305"
FT CONFLICT 446
FT /note="Q -> P (in Ref. 1; CAA52239)"
FT /evidence="ECO:0000305"
FT CONFLICT 449..450
FT /note="ST -> RP (in Ref. 1; CAA52239)"
FT /evidence="ECO:0000305"
FT HELIX 186..196
FT /evidence="ECO:0007829|PDB:7CBY"
FT HELIX 204..214
FT /evidence="ECO:0007829|PDB:7CBY"
FT HELIX 216..219
FT /evidence="ECO:0007829|PDB:7CBY"
FT HELIX 222..235
FT /evidence="ECO:0007829|PDB:7CBY"
FT STRAND 239..242
FT /evidence="ECO:0007829|PDB:7CBY"
FT STRAND 254..257
FT /evidence="ECO:0007829|PDB:7CBY"
FT HELIX 259..263
FT /evidence="ECO:0007829|PDB:7CBY"
FT STRAND 264..266
FT /evidence="ECO:0007829|PDB:7CBY"
FT TURN 268..270
FT /evidence="ECO:0007829|PDB:7CBY"
FT STRAND 272..275
FT /evidence="ECO:0007829|PDB:7CBY"
SQ SEQUENCE 489 AA; 52352 MW; 897945F9CE4F2A71 CRC64;
MLDMGDRKEV KMIPKSSFSI NSLVPEAVQN DNHHASHGHH NSHHPQHHHH HHHHHHHPPP
PAPQPPPPPQ QQQPPPPPPP APQPPQTRGA PAADDDKGPQ QLLLPPPPPP PPAAALDGAK
ADGLGGKGEP GGGPGELAPV GPDEKEKGAG AGGEEKKGAG EGGKDGEGGK EGEKKNGKYE
KPPFSYNALI MMAIRQSPEK RLTLNGIYEF IMKNFPYYRE NKQGWQNSIR HNLSLNKCFV
KVPRHYDDPG KGNYWMLDPS SDDVFIGGTT GKLRRRSTTS RAKLAFKRGA RLTSTGLTFM
DRAGSLYWPM SPFLSLHHPR ASSTLSYNGT TSAYPSHPMP YSSVLTQNSL GNNHSFSTAN
GLSVDRLVNG EIPYATHHLT AAALAASVPC GLSVPCSGTY SLNPCSVNLL AGQTSYFFPH
VPHPSMTSQS STSMSARAAS SSTSPQAPST LPCESLRPSL PSFTTGLSGG LSDYFTHQNQ
GSSSNPLIH
