ID   FOXG1_MNELE             Reviewed;         318 AA.
AC   Q8ITI5;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Forkhead box protein G1 {ECO:0000250|UniProtKB:P55316};
DE   AltName: Full=Brain factor 1 {ECO:0000303|PubMed:12185487};
DE            Short=ctenoBF-1 {ECO:0000303|PubMed:12185487};
GN   Name=FOXG1 {ECO:0000250|UniProtKB:P55316};
GN   Synonyms=BF-1 {ECO:0000303|PubMed:12185487};
OS   Mnemiopsis leidyi (Sea walnut) (Warty comb jellyfish).
OC   Eukaryota; Metazoa; Ctenophora; Tentaculata; Lobata; Bolinopsidae;
OC   Mnemiopsis.
OX   NCBI_TaxID=27923;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAN17798.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROBABLE FUNCTION, AND TISSUE SPECIFICITY.
RC   TISSUE=Larva {ECO:0000269|PubMed:12185487};
RX   PubMed=12185487; DOI=10.1007/s00427-002-0248-x;
RA   Yamada A., Martindale M.Q.;
RT   "Expression of the ctenophore Brain Factor 1 forkhead gene ortholog
RT   (ctenoBF-1) mRNA is restricted to the presumptive mouth and feeding
RT   apparatus: implications for axial organization in the Metazoa.";
RL   Dev. Genes Evol. 212:338-348(2002).
CC   -!- FUNCTION: Probable transcription factor. {ECO:0000269|PubMed:12185487}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in uncleaved zygotes with increasing
CC       intensity until the 8-cell stage. Confined to aboral region during 16-
CC       cell and 32-cell stage, afterwards found in ectodermal derivatives, in
CC       particular surrounding the blastopore and along the tentacular axis.
CC       Not expressed in the apical organ nor along the esophageal axis in
CC       mesodermal and endodermal derivatives. Expression subsides after
CC       hatching. {ECO:0000269|PubMed:12185487}.
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DR   EMBL; AF477500; AAN17798.1; -; mRNA.
DR   AlphaFoldDB; Q8ITI5; -.
DR   SMR; Q8ITI5; -.
DR   HOGENOM; CLU_875214_0_0_1; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..318
FT                   /note="Forkhead box protein G1"
FT                   /id="PRO_0000389517"
FT   DNA_BIND        27..121
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          193..258
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        193..230
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        231..245
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   318 AA;  35384 MW;  E5DE04AAE3BCE36E CRC64;
     MVVTTATKPH PFSIENILKS ASPKPQKPLF SYNALIAMAI SQSPLKKLTL SEIYDFIIET
     FPYYRDNKKG WQNSIRHNLS LNKCFVKVPR HYNDPGKGNY WMLNPNSDEV FIGGKLRRRP
     GQNGGSLESY MHLKTRTSPY QRGDTVCKRD RVVYLSNSGA GNCQFYQPVP CSSPTAMLSR
     SSLIVQTSPT TLTIPHHPPQ NYIQTLSPNV SPVRVGNQTS PRQSALPSSS LPLLPSPPSL
     PSKLSSPPLP SLSTNLPSPP LDTGDILLSP FLRQTVDSTS QNFLEHMIRI REQVQRSGHL
     ALAQSRAVVY QPIPRKSL