FOXG1_MOUSE
ID FOXG1_MOUSE Reviewed; 481 AA.
AC Q60987; Q80VP3;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 183.
DE RecName: Full=Forkhead box protein G1;
DE Short=FoxG1;
DE AltName: Full=Brain factor 1;
DE Short=BF-1;
DE Short=BF1;
DE AltName: Full=Forkhead-related protein FKHL1;
GN Name=Foxg1; Synonyms=Fkhl1, Foxg1b, Hfhbf1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8738140; DOI=10.1016/0169-328x(95)00276-x;
RA Li H., Tao W., Lai E.;
RT "Characterization of the structure and function of the gene for
RT transcription factor BF-1, an essential regulator of forebrain
RT development.";
RL Brain Res. Mol. Brain Res. 37:96-104(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, AND INTERACTION WITH TLE6 AND TLE1.
RX PubMed=16314515; DOI=10.1128/mcb.25.24.10916-10929.2005;
RA Marcal N., Patel H., Dong Z., Belanger-Jasmin S., Hoffman B.,
RA Helgason C.D., Dang J., Stifani S.;
RT "Antagonistic effects of Grg6 and Groucho/TLE on the transcription
RT repression activity of brain factor 1/FoxG1 and cortical neuron
RT differentiation.";
RL Mol. Cell. Biol. 25:10916-10929(2005).
CC -!- FUNCTION: Transcription repression factor which plays an important role
CC in the establishment of the regional subdivision of the developing
CC brain and in the development of the telencephalon.
CC {ECO:0000269|PubMed:16314515}.
CC -!- SUBUNIT: Interacts with KDM5B (By similarity). Interacts with GRG6/TLE6
CC (PubMed:16314515). Interacts with TLE1; the interaction is inhibited by
CC interaction with TLE6/GRG6 (PubMed:16314515).
CC {ECO:0000250|UniProtKB:P55316, ECO:0000269|PubMed:16314515}.
CC -!- INTERACTION:
CC Q60987; Q9Z2D6-1: Mecp2; NbExp=4; IntAct=EBI-11166131, EBI-26609102;
CC Q60987; Q9Z2D6-2: Mecp2; NbExp=2; IntAct=EBI-11166131, EBI-26609115;
CC Q60987; O43524: FOXO3; Xeno; NbExp=5; IntAct=EBI-11166131, EBI-1644164;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P55316}.
CC -!- TISSUE SPECIFICITY: CNS, and nasal half of the retina.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U36760; AAB42158.1; -; mRNA.
DR EMBL; BC046958; AAH46958.2; -; mRNA.
DR CCDS; CCDS25899.1; -.
DR RefSeq; NP_001153584.1; NM_001160112.1.
DR RefSeq; NP_032267.1; NM_008241.2.
DR AlphaFoldDB; Q60987; -.
DR SMR; Q60987; -.
DR BioGRID; 200291; 5.
DR IntAct; Q60987; 5.
DR MINT; Q60987; -.
DR STRING; 10090.ENSMUSP00000136372; -.
DR iPTMnet; Q60987; -.
DR PhosphoSitePlus; Q60987; -.
DR MaxQB; Q60987; -.
DR PaxDb; Q60987; -.
DR PRIDE; Q60987; -.
DR ProteomicsDB; 271714; -.
DR Antibodypedia; 9316; 298 antibodies from 33 providers.
DR DNASU; 15228; -.
DR Ensembl; ENSMUST00000021333; ENSMUSP00000021333; ENSMUSG00000020950.
DR Ensembl; ENSMUST00000179669; ENSMUSP00000136372; ENSMUSG00000020950.
DR GeneID; 15228; -.
DR KEGG; mmu:15228; -.
DR UCSC; uc007nmf.2; mouse.
DR CTD; 2290; -.
DR MGI; MGI:1347464; Foxg1.
DR VEuPathDB; HostDB:ENSMUSG00000020950; -.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000160678; -.
DR HOGENOM; CLU_040357_1_0_1; -.
DR InParanoid; Q60987; -.
DR OMA; AHPMSYS; -.
DR OrthoDB; 1270467at2759; -.
DR PhylomeDB; Q60987; -.
DR TreeFam; TF316127; -.
DR Reactome; R-MMU-9617828; FOXO-mediated transcription of cell cycle genes.
DR BioGRID-ORCS; 15228; 7 hits in 74 CRISPR screens.
DR ChiTaRS; Foxg1; mouse.
DR PRO; PR:Q60987; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q60987; protein.
DR Bgee; ENSMUSG00000020950; Expressed in cortical plate and 131 other tissues.
DR ExpressionAtlas; Q60987; baseline and differential.
DR Genevisible; Q60987; MM.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IC:NTNU_SB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0007568; P:aging; IEA:Ensembl.
DR GO; GO:0016199; P:axon midline choice point recognition; IMP:MGI.
DR GO; GO:0048667; P:cell morphogenesis involved in neuron differentiation; IMP:MGI.
DR GO; GO:0021954; P:central nervous system neuron development; IMP:MGI.
DR GO; GO:0021987; P:cerebral cortex development; IDA:MGI.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:MGI.
DR GO; GO:0030900; P:forebrain development; IMP:MGI.
DR GO; GO:0042472; P:inner ear morphogenesis; IMP:MGI.
DR GO; GO:0045665; P:negative regulation of neuron differentiation; IMP:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:0007405; P:neuroblast proliferation; IMP:MGI.
DR GO; GO:0022008; P:neurogenesis; IDA:MGI.
DR GO; GO:0030182; P:neuron differentiation; IMP:MGI.
DR GO; GO:0048664; P:neuron fate determination; IDA:MGI.
DR GO; GO:0045787; P:positive regulation of cell cycle; IMP:MGI.
DR GO; GO:0002052; P:positive regulation of neuroblast proliferation; IMP:MGI.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IGI:MGI.
DR GO; GO:0021852; P:pyramidal neuron migration to cerebral cortex; IDA:MGI.
DR GO; GO:0051726; P:regulation of cell cycle; IDA:MGI.
DR GO; GO:0010468; P:regulation of gene expression; IMP:MGI.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; IMP:MGI.
DR GO; GO:2000177; P:regulation of neural precursor cell proliferation; IGI:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..481
FT /note="Forkhead box protein G1"
FT /id="PRO_0000091837"
FT DNA_BIND 172..263
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 31..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 241..336
FT /note="Required for interaction with TLE6"
FT /evidence="ECO:0000269|PubMed:16314515"
FT REGION 375..398
FT /note="Interaction with KDM5B"
FT /evidence="ECO:0000250"
FT REGION 419..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..58
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..85
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..172
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 481 AA; 51625 MW; FF6786C3513AB452 CRC64;
MLDMGDRKEV KMIPKSSFSI NSLVPEAVQN DNHHASHGHH NSHHPQHHHH HHHHHHPPPP
APQPPPPPPQ QQQQQPPPAP QPPQARGAPA ADDDKGPQPL LLPPSTALDG AKADALGAKG
EPGGGPAELA PVGPDEKEKG AGAGGEEKKG AGEGGKDGEG GKEGDKKNGK YEKPPFSYNA
LIMMAIRQSP EKRLTLNGIY EFIMKNFPYY RENKQGWQNS IRHNLSLNKC FVKVPRHYDD
PGKGNYWMLD PSSDDVFIGG TTGKLRRRST TSRAKLAFKR GARLTSTGLT FMDRAGSLYW
PMSPFLSLHH PRASSTLSYN GTTSAYPSHP MPYSSVLTQN SLGNNHSFST ANGLSVDRLV
NGEIPYATHH LTAAALAASV PCGLSVPCSG TYSLNPCSVN LLAGQTSYFF PHVPHPSMTS
QTSTSMSARA ASSSTSPQAP STLPCESLRP SLPSFTTGLS GGLSDYFTHQ NQGSSSNPLI
H
