ID   FOXG1_PIPRU             Reviewed;         484 AA.
AC   Q1A1A4;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Forkhead box protein G1;
DE            Short=FoxG1;
GN   Name=FOXG1;
OS   Pipistrellus rusticus (Rusty pipistrelle).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Pipistrellus.
OX   NCBI_TaxID=372076;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Bredenkamp N., Illing N.;
RT   "Evolutionary evolution of forkhead box G1.";
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription repression factor which plays an important role
CC       in the establishment of the regional subdivision of the developing
CC       brain and in the development of the telencephalon.
CC       {ECO:0000250|UniProtKB:P55316}.
CC   -!- SUBUNIT: Interacts with KDM5B (By similarity). Interacts with GRG6/TLE6
CC       (By similarity). Interacts with TLE1; the interaction is inhibited by
CC       interaction with TLE6/GRG6 (By similarity).
CC       {ECO:0000250|UniProtKB:P55316, ECO:0000250|UniProtKB:Q60987}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DQ387963; ABD38846.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q1A1A4; -.
DR   SMR; Q1A1A4; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Nucleus; Proto-oncogene; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..484
FT                   /note="Forkhead box protein G1"
FT                   /id="PRO_0000254888"
FT   DNA_BIND        176..270
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          31..176
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          244..339
FT                   /note="Required for interaction with TLE6"
FT                   /evidence="ECO:0000250|UniProtKB:Q60987"
FT   REGION          378..401
FT                   /note="Interaction with KDM5B"
FT                   /evidence="ECO:0000250"
FT   REGION          422..450
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..58
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..82
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        135..175
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   484 AA;  51731 MW;  94A1B82C8812A876 CRC64;
     MLDMGDRKEV KMIPKSSFSI NSLVPEAVQN DNHHASHGHH NSHHPQHHHH HHHHHHPPPP
     APQPPPPPQQ QPPPPQAPQP PQARGAPAAD DDKGPQQLLL PPPPPPAAAL DGAKADGLGG
     KGEPGGGGAG ELAPVGPDEK EKGAGAGGEE KKGAGEGGKD GEGGKEGEKK NGKYEKPPFS
     YNALIMMAIR QSPEKRLTLN GIYEFIMKNF PYYRENKQGW QNSIRHNLSL NKCFVKVPRH
     YDDPGKGNYW MLDPSSDDVF IGGTTGKLRR RSTTSRAKLA FKRGARLTST GLTFMDRAGS
     LYWPMSPFLS LHHPRASSTL SYNGTTSAYP SHPMPYSSVL TQNSLGNNHS FSTANGLSVD
     RLVNGEIPYA THHLTAAALA ASVPCGLSVP CSGTYSLNPC SVNLLAGQTS YFFPHVPHPS
     MTSQSSTSMS ARAASSSTSP QAPSTLPCES LRPSLPSFTT GLSGGLSDYF THQNQGSSSN
     PLIH