FOXG1_RAT
ID FOXG1_RAT Reviewed; 480 AA.
AC Q00939;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Forkhead box protein G1;
DE Short=FoxG1;
DE AltName: Full=Brain factor 1;
DE Short=BF-1;
DE Short=BF1;
DE AltName: Full=Forkhead-related protein FKHL1;
GN Name=Foxg1; Synonyms=Fkhl1, Foxg1b;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=1350202; DOI=10.1016/0896-6273(92)90210-5;
RA Tao W., Lai E.;
RT "Telencephalon-restricted expression of BF-1, a new member of the HNF-
RT 3/fork head gene family, in the developing rat brain.";
RL Neuron 8:957-966(1992).
CC -!- FUNCTION: Transcription repression factor which plays an important role
CC in the establishment of the regional subdivision of the developing
CC brain and in the development of the telencephalon.
CC {ECO:0000250|UniProtKB:P55316}.
CC -!- SUBUNIT: Interacts with KDM5B (By similarity). Interacts with GRG6/TLE6
CC (By similarity). Interacts with TLE1; the interaction is inhibited by
CC interaction with TLE6/GRG6 (By similarity).
CC {ECO:0000250|UniProtKB:P55316, ECO:0000250|UniProtKB:Q60987}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P55316}.
CC -!- TISSUE SPECIFICITY: Is expressed in the cortex, olfactory bulb,
CC hippocampus, and caudate putamen.
CC -!- DEVELOPMENTAL STAGE: More abundant in fetal brain compared with the
CC adult brain.
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DR EMBL; M87634; AAA40812.1; -; mRNA.
DR PIR; JH0672; JH0672.
DR RefSeq; NP_036692.1; NM_012560.2.
DR AlphaFoldDB; Q00939; -.
DR BMRB; Q00939; -.
DR SMR; Q00939; -.
DR BioGRID; 246542; 1.
DR STRING; 10116.ENSRNOP00000067118; -.
DR iPTMnet; Q00939; -.
DR PhosphoSitePlus; Q00939; -.
DR PaxDb; Q00939; -.
DR Ensembl; ENSRNOT00000075349; ENSRNOP00000067118; ENSRNOG00000047891.
DR Ensembl; ENSRNOT00000107556; ENSRNOP00000082177; ENSRNOG00000047891.
DR Ensembl; ENSRNOT00000116180; ENSRNOP00000077714; ENSRNOG00000047891.
DR GeneID; 24370; -.
DR KEGG; rno:24370; -.
DR UCSC; RGD:2619; rat.
DR CTD; 2290; -.
DR RGD; 2619; Foxg1.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000160678; -.
DR HOGENOM; CLU_040357_1_0_1; -.
DR InParanoid; Q00939; -.
DR OMA; AHPMSYS; -.
DR OrthoDB; 1270467at2759; -.
DR PhylomeDB; Q00939; -.
DR Reactome; R-RNO-9617828; FOXO-mediated transcription of cell cycle genes.
DR PRO; PR:Q00939; -.
DR Proteomes; UP000002494; Chromosome 6.
DR Bgee; ENSRNOG00000047891; Expressed in Ammon's horn and 3 other tissues.
DR Genevisible; Q00939; RN.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:RGD.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0007568; P:aging; IEP:RGD.
DR GO; GO:0016199; P:axon midline choice point recognition; ISO:RGD.
DR GO; GO:0007420; P:brain development; IEP:RGD.
DR GO; GO:0048667; P:cell morphogenesis involved in neuron differentiation; ISO:RGD.
DR GO; GO:0021954; P:central nervous system neuron development; ISO:RGD.
DR GO; GO:0021987; P:cerebral cortex development; ISO:RGD.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; ISO:RGD.
DR GO; GO:0030900; P:forebrain development; ISO:RGD.
DR GO; GO:0042472; P:inner ear morphogenesis; ISO:RGD.
DR GO; GO:0045665; P:negative regulation of neuron differentiation; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:RGD.
DR GO; GO:0007405; P:neuroblast proliferation; IEA:Ensembl.
DR GO; GO:0022008; P:neurogenesis; ISO:RGD.
DR GO; GO:0048664; P:neuron fate determination; ISO:RGD.
DR GO; GO:0045787; P:positive regulation of cell cycle; ISO:RGD.
DR GO; GO:0002052; P:positive regulation of neuroblast proliferation; ISO:RGD.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; ISO:RGD.
DR GO; GO:0021852; P:pyramidal neuron migration to cerebral cortex; ISO:RGD.
DR GO; GO:0051726; P:regulation of cell cycle; ISO:RGD.
DR GO; GO:0010468; P:regulation of gene expression; ISO:RGD.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; ISO:RGD.
DR GO; GO:2000177; P:regulation of neural precursor cell proliferation; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..480
FT /note="Forkhead box protein G1"
FT /id="PRO_0000091838"
FT DNA_BIND 171..262
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 31..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 240..335
FT /note="Required for interaction with TLE6"
FT /evidence="ECO:0000250|UniProtKB:Q60987"
FT REGION 374..397
FT /note="Interaction with KDM5B"
FT /evidence="ECO:0000250"
FT REGION 418..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..58
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..84
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..171
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 480 AA; 51466 MW; 00425B2F5298F444 CRC64;
MLDMGDRKEV KMIPKSSFSI NSLVPEAVQN DNHHASHGHH NSHHPQHHHH HHHHHHPPPP
APQPPPPPPQ QQQQPPPAPQ PPQARGAPAA DDDKGPQPLL LPPSAALDGA KADALGAKGE
PGGGPAELAP VGPDEKEKGA GAGGEEKKGA GEGGKDGEGG KEGDKKNGKY EKPPFSYNAL
IMMAIRQSPE KRLTLNGIYE FIMKNFPYYR ENKQGWQNSI RHNLSLNKCF VKVPRHYDDP
GKGNYWMLDP SSDDVFIGGT TGKLRRRSTT SRAKLAFKRG ARLTSTGLTF MDRAGSLYWP
MSPFLSLHHP RASSTLSYNG TTSAYPSHPM PYSSVLTQNS LGNNHSFSTA NGLSVDRLVN
GEIPYATHHL TAAALAASVP CGLSVPCSGT YSLNPCSVNL LAGQTSYFFP HVPHPSMTSQ
TSTSMSARAA SSSTSPQAPS TLPCESLRPS LPSFTTGLSG GLSDYFTHQN QGSSSNPLIH
