FOXG1_XENLA
ID FOXG1_XENLA Reviewed; 436 AA.
AC Q9YHC5; Q9PS85;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Forkhead box protein G1;
DE Short=FoxG1;
DE AltName: Full=Brain factor 1;
DE Short=BF-1;
DE Short=xBF-1;
DE Short=xBF1;
DE AltName: Full=Forkhead protein 4;
DE Short=FKH-4;
DE Short=xFKH4;
GN Name=foxg1 {ECO:0000303|PubMed:15656969}; Synonyms=bf-1, bf1, fkh4;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAC79501.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Embryo {ECO:0000269|PubMed:9811573};
RX PubMed=9811573; DOI=10.1242/dev.125.24.4889;
RA Bourguignon C., Li J., Papalopulu N.;
RT "XBF-1, a winged helix transcription factor with dual activity, has a role
RT in positioning neurogenesis in Xenopus competent ectoderm.";
RL Development 125:4889-4900(1998).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 128-189, AND TISSUE SPECIFICITY.
RC TISSUE=Embryo {ECO:0000269|PubMed:7586752};
RX PubMed=7586752; DOI=10.1002/dvg.1020170203;
RA Dirksen M.-L., Jamrich M.;
RT "Differential expression of fork head genes during early Xenopus and
RT zebrafish development.";
RL Dev. Genet. 17:107-116(1995).
RN [3] {ECO:0000305}
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RC TISSUE=Embryo {ECO:0000269|PubMed:8951057};
RX PubMed=8951057; DOI=10.1242/dev.122.11.3409;
RA Papalopulu N., Kintner C.;
RT "A posteriorising factor, retinoic acid, reveals that anteroposterior
RT patterning controls the timing of neuronal differentiation in Xenopus
RT neuroectoderm.";
RL Development 122:3409-3418(1996).
RN [4]
RP FUNCTION.
RX PubMed=10096060; DOI=10.1016/s0925-4773(98)00190-7;
RA Gomez-Skarmeta J.L., de la Calle-Mustienes E., Modolell J., Mayor R.;
RT "Xenopus brain factor-2 controls mesoderm, forebrain and neural crest
RT development.";
RL Mech. Dev. 80:15-27(1999).
RN [5] {ECO:0000305}
RP FUNCTION.
RX PubMed=10683182; DOI=10.1242/dev.127.6.1303;
RA Hardcastle Z., Papalopulu N.;
RT "Distinct effects of XBF-1 in regulating the cell cycle inhibitor p27(XIC1)
RT and imparting a neural fate.";
RL Development 127:1303-1314(2000).
RN [6] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=11997220; DOI=10.1016/s1096-4959(01)00521-8;
RA Eagleson G.W., Dempewolf R.D.;
RT "The role of the anterior neural ridge and Fgf-8 in early forebrain
RT patterning and regionalization in Xenopus laevis.";
RL Comp. Biochem. Physiol. 132B:179-189(2002).
RN [7] {ECO:0000305}
RP REVIEW.
RX PubMed=15656969; DOI=10.1016/j.gene.2004.09.037;
RA Pohl B.S., Knoechel W.;
RT "Of fox and frogs: fox (fork head/winged helix) transcription factors in
RT Xenopus development.";
RL Gene 344:21-32(2005).
CC -!- FUNCTION: A neural-specific transcription factor that can act as both a
CC transcriptional activator and a transcriptional repressor. Both
CC represses and activates neuronal differentiation in a dose-dependent
CC manner, independently regulating cell fate choice and cell
CC proliferation. Converts ectoderm to a neural fate. Suppresses the
CC transcription of the cell cycle inhibitor p27xic1 and promotes the
CC proliferation of neuroectodermal cells at a high concentration.
CC Promotes the transcription of p27xic1 and inhibits ectodermal
CC proliferation at low concentrations. The transcription factors foxd1
CC and foxg1 mutually repress each other to pattern the forebrain.
CC {ECO:0000269|PubMed:10096060, ECO:0000269|PubMed:10683182,
CC ECO:0000269|PubMed:9811573}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC -!- TISSUE SPECIFICITY: At late gastrula and early neurula stages,
CC expressed in a narrow stripe at the anterior end of the neural plate.
CC At later stages, this stripe of expression thickens and expression also
CC appears in the lateral margin of the neural plate. The anterior line
CC differentiates to show expression in the forebrain, anterior (nasal)
CC retina and olfactory placode, whereas the lateral cells form neural
CC crest cells that migrate in the first branchial arch. In tailbud stages
CC and tadpoles, expressed primarily in the neuroepithelial cells of the
CC telencephalon. {ECO:0000269|PubMed:11997220,
CC ECO:0000269|PubMed:7586752, ECO:0000269|PubMed:8951057,
CC ECO:0000269|PubMed:9811573}.
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DR EMBL; AF101387; AAC79501.1; -; mRNA.
DR RefSeq; NP_001079165.1; NM_001085696.1.
DR AlphaFoldDB; Q9YHC5; -.
DR SMR; Q9YHC5; -.
DR GeneID; 373732; -.
DR KEGG; xla:373732; -.
DR CTD; 373732; -.
DR Xenbase; XB-GENE-865339; foxg1.L.
DR OrthoDB; 1270467at2759; -.
DR Proteomes; UP000186698; Chromosome 8L.
DR Bgee; 373732; Expressed in internal ear and 5 other tissues.
DR GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; NAS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IMP:UniProtKB.
DR GO; GO:0050768; P:negative regulation of neurogenesis; IMP:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:UniProtKB.
DR GO; GO:0050769; P:positive regulation of neurogenesis; IMP:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0042659; P:regulation of cell fate specification; IMP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; Differentiation; DNA-binding;
KW Neurogenesis; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..436
FT /note="Forkhead box protein G1"
FT /id="PRO_0000250441"
FT DNA_BIND 128..222
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..127
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 436 AA; 47967 MW; 4878CECF6646EC89 CRC64;
MLDMGDRKEV KMIPKSSFSI NSLMPEAVQN DNHPQPHHHH HHQQQPQHLQ LPQQHHLQPH
HRPLQEEDEL DKSLLEVKTE SLPPGKGDPA ASELPGEDKD KIDDKKVDGK DGDSGKDGGD
KKNGKYEKPP FSYNALIMMA IRQSPEKRLT LNGIYEFIMK NFPYYRENKQ GWQNSIRHNL
SLNKCFVKVP RHYDDPGKGN YWMLDPSSDD VFIGGTTGKL RRRSTTSRAK LAFKRGARLT
STGLTFMDRA GSLYWPMSPF LSLHHPRASS TLSYNGTTSA YPSQPMPYSS VLTQNSLGNN
HSFSTSNGLS VDRLVNGEIP YATHHLTAAA LAASVPCGLP VPCSGTYSLN PCSVNLLAGQ
TGYFFPHVPH PSITSQSSTS MAARAASSST SPQAPSTLPC ESLRPALPSF TTGLSGGLSD
YFTHQNQGSS SNSLIH
