ALBU1_SALSA
ID ALBU1_SALSA Reviewed; 608 AA.
AC P21848;
DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1991, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Albumin 1;
DE Flags: Precursor;
GN Name=alb1;
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=2261082; DOI=10.1089/dna.1990.9.647;
RA Byrnes L., Gannon F.;
RT "Atlantic salmon (Salmo salar) serum albumin: cDNA sequence, evolution, and
RT tissue expression.";
RL DNA Cell Biol. 9:647-655(1990).
CC -!- FUNCTION: Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones,
CC bilirubin and drugs. Its main function is the regulation of the
CC colloidal osmotic pressure of blood.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Plasma.
CC -!- SIMILARITY: Belongs to the ALB/AFP/VDB family. {ECO:0000255|PROSITE-
CC ProRule:PRU00769}.
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DR EMBL; X52397; CAA36643.1; -; mRNA.
DR PIR; A36238; ABONS1.
DR RefSeq; NP_001117137.1; NM_001123665.1.
DR AlphaFoldDB; P21848; -.
DR SMR; P21848; -.
DR STRING; 8030.ENSSSAP00000093436; -.
DR GeneID; 100136575; -.
DR KEGG; sasa:100136575; -.
DR CTD; 100136575; -.
DR OrthoDB; 906547at2759; -.
DR Proteomes; UP000087266; Chromosome ssa01.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00015; ALBUMIN; 3.
DR InterPro; IPR000264; ALB/AFP/VDB.
DR InterPro; IPR020858; Serum_albumin-like.
DR InterPro; IPR021177; Serum_albumin/AFP/Afamin.
DR InterPro; IPR020857; Serum_albumin_CS.
DR InterPro; IPR014760; Serum_albumin_N.
DR PANTHER; PTHR11385; PTHR11385; 1.
DR Pfam; PF00273; Serum_albumin; 3.
DR PIRSF; PIRSF002520; Serum_albumin_subgroup; 1.
DR PRINTS; PR00802; SERUMALBUMIN.
DR SMART; SM00103; ALBUMIN; 3.
DR SUPFAM; SSF48552; SSF48552; 3.
DR PROSITE; PS00212; ALBUMIN_1; 2.
DR PROSITE; PS51438; ALBUMIN_2; 3.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Lipid-binding; Metal-binding;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..14
FT /evidence="ECO:0000255"
FT PROPEP 15..18
FT /id="PRO_0000001085"
FT CHAIN 19..608
FT /note="Albumin 1"
FT /id="PRO_0000001086"
FT DOMAIN 19..205
FT /note="Albumin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT DOMAIN 206..398
FT /note="Albumin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT DOMAIN 402..600
FT /note="Albumin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT CARBOHYD 501
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 26..72
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT DISULFID 71..80
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT DISULFID 93..108
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT DISULFID 107..118
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT DISULFID 142..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT DISULFID 186..195
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT DISULFID 218..264
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT DISULFID 263..271
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT DISULFID 283..299
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT DISULFID 298..309
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT DISULFID 336..381
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT DISULFID 380..389
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT DISULFID 414..460
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT DISULFID 459..471
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT DISULFID 484..500
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT DISULFID 499..510
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT DISULFID 537..582
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
FT DISULFID 581..590
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00769"
SQ SEQUENCE 608 AA; 67151 MW; A2BD2AE2664B11EA CRC64;
MQWLSVCSLL VLLSVLSRSQ AQNQICTIFT EAKEDGFKSL ILVGLAQNLP DSTLGDLVPL
IAEALAMGVK CCSDTPPEDC ERDVADLFQS AVCSSETLVE KNDLKMCCEK TAAERTHCFV
DHKAKIPRDL SLKAELPAAD QCEDFKKDHK AFVGRFIFKF SKSNPMLPPH VVLAIAKGYG
EVLTTCCGEA EAQTCFDTKK ATFQHAVMKR VAELRSLCIV HKKYGDRVVK AKKLVQYSQK
MPQASFQEMG GMVDKIVATV APCCSGDMVT CMKERKTLVD EVCADESVLS RAAGLSACCK
EDAVHRGSCV EAMKPDPKPD GLSEHYDIHA DIAAVCQTFT KTPDVAMGKL VYEISVRHPE
SSQQVILRFA KEAEQALLQC CDMEDHAECV KTALAGSDID KKITDETDYY KKMCAAEAAV
SDDSFEKSMM VYYTRIMPQA SFDQLHMVSE TVHDVLHACC KDEQGHFVLP CAEEKLTDAI
DATCDDYDPS SINPHIAHCC NQSYSMRRHC ILAIQPDTEF TPPELDASSF HMGPELCTKD
SKDLLLSGKK LLYGVVRHKT TITEDHLKTI STKYHTMKEK CCAAEDQAAC FTEEAPKLVS
ESAELVKV