FOXI1_MOUSE
ID FOXI1_MOUSE Reviewed; 372 AA.
AC Q922I5; Q5SRI5; Q9D299;
DT 07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2007, sequence version 2.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Forkhead box protein I1;
GN Name=Foxi1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAB31957.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAB31957.2};
RC TISSUE=Thymus {ECO:0000312|EMBL:BAB31957.2};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4] {ECO:0000305}
RP FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=12642503; DOI=10.1242/dev.00376;
RA Hulander M., Kiernan A.E., Blomqvist S.R., Carlsson P., Samuelsson E.-J.,
RA Johansson B.R., Steel K.P., Enerbaeck S.;
RT "Lack of pendrin expression leads to deafness and expansion of the
RT endolymphatic compartment in inner ears of Foxi1 null mutant mice.";
RL Development 130:2013-2025(2003).
RN [5] {ECO:0000305}
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=15173882; DOI=10.1172/jci200420665;
RA Blomqvist S.R., Vidarsson H., Fitzgerald S., Johansson B.R., Ollerstam A.,
RA Brown R., Persson A.E.G., Bergstroem G., Enerbaeck S.;
RT "Distal renal tubular acidosis in mice that lack the forkhead transcription
RT factor Foxi1.";
RL J. Clin. Invest. 113:1560-1570(2004).
CC -!- FUNCTION: Transcriptional activator required for the development of
CC normal hearing, sense of balance and kidney function. Required for the
CC expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial
CC cells and the development of the endolymphatic system in the inner ear.
CC Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1
CC and the differentiation of intercalated cells in the epithelium of
CC distal renal tubules. {ECO:0000269|PubMed:12642503,
CC ECO:0000269|PubMed:15173882}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Expressed in intercalated cells of the epithelium
CC of the distal renal tubule. {ECO:0000269|PubMed:15173882}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the entire otic vesicle at stage 9.5
CC dpc gradually restricted to the epithelium of the endolymphatic ducts
CC at stage 16.5 dpc. {ECO:0000269|PubMed:12642503}.
CC -!- DISRUPTION PHENOTYPE: Mice are deaf, impaired in their sense of balance
CC and suffer from distal renal tubular acidosis.
CC {ECO:0000269|PubMed:12642503, ECO:0000269|PubMed:15173882}.
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DR EMBL; AK019994; BAB31957.2; -; mRNA.
DR EMBL; AL671971; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC007475; AAH07475.2; -; mRNA.
DR CCDS; CCDS24539.1; -.
DR RefSeq; NP_076396.3; NM_023907.4.
DR AlphaFoldDB; Q922I5; -.
DR SMR; Q922I5; -.
DR STRING; 10090.ENSMUSP00000058651; -.
DR iPTMnet; Q922I5; -.
DR PhosphoSitePlus; Q922I5; -.
DR PaxDb; Q922I5; -.
DR PRIDE; Q922I5; -.
DR ProteomicsDB; 267399; -.
DR Antibodypedia; 28812; 506 antibodies from 31 providers.
DR DNASU; 14233; -.
DR Ensembl; ENSMUST00000060271; ENSMUSP00000058651; ENSMUSG00000047861.
DR GeneID; 14233; -.
DR KEGG; mmu:14233; -.
DR UCSC; uc007ikw.1; mouse.
DR CTD; 2299; -.
DR MGI; MGI:1096329; Foxi1.
DR VEuPathDB; HostDB:ENSMUSG00000047861; -.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000161316; -.
DR HOGENOM; CLU_046860_1_0_1; -.
DR InParanoid; Q922I5; -.
DR OMA; TGIIYHR; -.
DR OrthoDB; 1270467at2759; -.
DR PhylomeDB; Q922I5; -.
DR TreeFam; TF316127; -.
DR BioGRID-ORCS; 14233; 6 hits in 71 CRISPR screens.
DR ChiTaRS; Foxi1; mouse.
DR PRO; PR:Q922I5; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q922I5; protein.
DR Bgee; ENSMUSG00000047861; Expressed in inner medullary collecting duct and 60 other tissues.
DR Genevisible; Q922I5; MM.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IC:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:MGI.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0042472; P:inner ear morphogenesis; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR033065; Foxi1.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11829:SF180; PTHR11829:SF180; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW Activator; Deafness; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..372
FT /note="Forkhead box protein I1"
FT /id="PRO_0000091847"
FT DNA_BIND 117..211
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 66
FT /note="L -> F (in Ref. 1; BAB31957)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 372 AA; 40798 MW; 3856C263040CFB44 CRC64;
MSSFDLPAPS PPRCSPQFPS IGQEPPEMNL YYENFFHPQG MPSPQRPTSF EGGGEYGTTP
NPYLWLNGPA MTPPPYLPGT NASPFLPQAY GMQRQLLPSD LGWLPIPSQE ELMKLVRPPY
SYSALIAMAI HGAPDQRLTL SQIYQYVADN FPFYNKSKAG WQNSIRHNLS LNDCFKKVPR
DEDDPGKGNY WTLDPNCEKM FDNGNFRRKR KRKSDSSSST SSLASEKTEN GLLASSPKPT
EPQEVLDTAS PDTTTSSPEK RSSPAPSGTP CLNNFLSTMT AYVSGTNPIS RSVATPGLSS
EPIDKMGQNS LNFNSYTPLT NLSSHGNGGE WANPVATNAL GYGGSVFNQF SPHFYNSINT
NGILFPREGT EV
