FOXI2_MOUSE
ID FOXI2_MOUSE Reviewed; 311 AA.
AC Q3I5G5; Q8BIK9;
DT 07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Forkhead box protein I2;
GN Name=Foxi2 {ECO:0000312|MGI:MGI:3028075};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAY79175.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAY79175.1};
RC TISSUE=Midbrain {ECO:0000312|EMBL:AAY79175.1};
RX PubMed=16289364; DOI=10.1016/j.bbaexp.2005.09.003;
RA Wijchers P.J.E.C., Hoekman M.F.M., Burbach J.P.H., Smidt M.P.;
RT "Cloning and analysis of the murine Foxi2 transcription factor.";
RL Biochim. Biophys. Acta 1731:133-138(2005).
RN [2] {ECO:0000312|EMBL:BAC32291.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAC32291.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:BAC32291.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3] {ECO:0000312|EMBL:AAH96623.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAH96623.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:AAH96623.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Possible transcriptional activator. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DEVELOPMENTAL STAGE: Expressed in a subset of cells of the olfactory
CC epithelium, in the dental epithelium, in developing whiskers and in
CC cells lining the endolymphatic duct of the inner ear at stage 16.5 dpc.
CC Also expressed in kidney, hair follicles, thymus and in collecting
CC ducts from the mandibular gland as well as in a subset of epithelial
CC cells lining the sublingual and submaxillary ducts from the salivary
CC glands to the oral cavity at stage 18.5 dpc. Expressed in the
CC developing brain along a neuromeric boundary between prosomeres p5 and
CC p6 as well as in the neural layer of the retina.
CC {ECO:0000269|PubMed:16289364}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH96623.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC32291.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; DQ078268; AAY79175.1; -; mRNA.
DR EMBL; AK045276; BAC32291.1; ALT_INIT; mRNA.
DR EMBL; BC096623; AAH96623.1; ALT_INIT; mRNA.
DR CCDS; CCDS21942.2; -.
DR RefSeq; NP_899016.1; NM_183193.2.
DR AlphaFoldDB; Q3I5G5; -.
DR SMR; Q3I5G5; -.
DR STRING; 10090.ENSMUSP00000053641; -.
DR PhosphoSitePlus; Q3I5G5; -.
DR PaxDb; Q3I5G5; -.
DR PRIDE; Q3I5G5; -.
DR ABCD; Q3I5G5; 1 sequenced antibody.
DR Antibodypedia; 32477; 80 antibodies from 18 providers.
DR DNASU; 270004; -.
DR Ensembl; ENSMUST00000060356; ENSMUSP00000053641; ENSMUSG00000048377.
DR GeneID; 270004; -.
DR KEGG; mmu:270004; -.
DR CTD; 399823; -.
DR MGI; MGI:3028075; Foxi2.
DR VEuPathDB; HostDB:ENSMUSG00000048377; -.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000161176; -.
DR InParanoid; Q3I5G5; -.
DR OrthoDB; 1270467at2759; -.
DR PhylomeDB; Q3I5G5; -.
DR BioGRID-ORCS; 270004; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q3I5G5; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q3I5G5; protein.
DR Bgee; ENSMUSG00000048377; Expressed in perihilar interstitium and 56 other tissues.
DR ExpressionAtlas; Q3I5G5; baseline and differential.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..311
FT /note="Forkhead box protein I2"
FT /id="PRO_0000091848"
FT DNA_BIND 99..193
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 188..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 311 AA; 32784 MW; E4C510D9004DDF2C CRC64;
MAGFCDSLGS CSVPHGLTRA IAHPPSYGRT DLSSGRRLWV NSAALSPAPY ATGPGPAPSY
AAATLAVPGS LLGASGGLAG ADLAWLSLSG QQELLRLVRP PYSYSALIAM AIQSAPLRRL
TLSQIYQYVA GNFPFYKRSK AGWQNSIRHN LSLNDCFKKV PRDENDPGKG NYWTLDPNCE
KMFDNGNFRR KRRRRGETSE AAVPGASSPE GTALEPRGST PQDPQTSPSP SEATTTCLSG
FSTAMGALAG GFGALPDGLA HDFSLRRPPP TAAAHSPQIP NTAPGFAPGH QTGATGFRMG
HLIYSRDGTE V
