ID   FOXI2_RAT               Reviewed;         101 AA.
AC   Q63248;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 132.
DE   RecName: Full=Forkhead box protein I2;
DE   AltName: Full=Hepatocyte nuclear factor 3 forkhead homolog 5;
DE            Short=HFH-5;
DE   Flags: Fragment;
GN   Name=Foxi2; Synonyms=Foxi1, Hfh5;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=Sprague-Dawley;
RX   PubMed=7683413; DOI=10.1073/pnas.90.9.3948;
RA   Clevidence D.E., Overdier D.G., Tao W., Qian X., Pani L., Lai E.,
RA   Costa R.H.;
RT   "Identification of nine tissue-specific transcription factors of the
RT   hepatocyte nuclear factor 3/forkhead DNA-binding-domain family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:3948-3952(1993).
CC   -!- FUNCTION: Possible transcriptional activator. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
CC   -!- TISSUE SPECIFICITY: Low levels in lung and liver.
CC       {ECO:0000269|PubMed:7683413}.
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DR   EMBL; L13205; AAA41321.1; -; mRNA.
DR   PIR; I60919; I60919.
DR   AlphaFoldDB; Q63248; -.
DR   SMR; Q63248; -.
DR   STRING; 10116.ENSRNOP00000025569; -.
DR   PaxDb; Q63248; -.
DR   UCSC; RGD:621739; rat.
DR   RGD; 621739; Foxi2.
DR   eggNOG; KOG2294; Eukaryota.
DR   InParanoid; Q63248; -.
DR   PhylomeDB; Q63248; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:RGD.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           <1..>101
FT                   /note="Forkhead box protein I2"
FT                   /id="PRO_0000091849"
FT   DNA_BIND        2..93
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   NON_TER         1
FT   NON_TER         101
SQ   SEQUENCE   101 AA;  11988 MW;  3BED48CF13A26F9C CRC64;
     LVRPPYSYSA LIAMAIQSAP RRRLTLSQIY QYVAGNFPFY KRTKAGWQNS IRHNLSLNDC
     FKKVPRDEND PGKGNYWMLD PNCEKMFDNG NFRRKRRRRG E