ID   FOXI2_XENTR             Reviewed;         368 AA.
AC   Q28HT3;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Forkhead box protein I2;
GN   Name=foxi2 {ECO:0000250|UniProtKB:Q5NDM2}; ORFNames=TGas144f13.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:CAJ83471.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possible transcriptional activator. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR760754; CAJ83471.1; -; mRNA.
DR   RefSeq; NP_001016544.1; NM_001016544.2.
DR   AlphaFoldDB; Q28HT3; -.
DR   SMR; Q28HT3; -.
DR   STRING; 8364.ENSXETP00000048326; -.
DR   PaxDb; Q28HT3; -.
DR   GeneID; 549298; -.
DR   KEGG; xtr:549298; -.
DR   CTD; 399823; -.
DR   Xenbase; XB-GENE-982122; foxi2.
DR   eggNOG; KOG2294; Eukaryota.
DR   InParanoid; Q28HT3; -.
DR   OrthoDB; 1270467at2759; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..368
FT                   /note="Forkhead box protein I2"
FT                   /id="PRO_0000247730"
FT   DNA_BIND        124..218
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          33..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          243..272
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        250..265
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   368 AA;  40439 MW;  F7DAF3D0A5FE6AA4 CRC64;
     MNTFGQQPTN PHAQDLLDMA MYCDHFSLYH QQQNQQLPQR PAAPPALGYG RNEYSSPTAS
     PYPWLNGPAM NSSPYLNGGS GSPYFPAGYG GGQRQFIPPS SGFGVADFPW LSIPNQADLL
     KMVRPPYSYS SLIAMAIQNN PEKKLTLSQI YSYVAENFPF YKKSKAGWQN SIRHNLSLND
     CFKKVARDDN DPGKGNYWTL DPNCEKMFDN GNFRRKRKRK SESVEAGFDG DASEDKKELA
     LKSLGSDSPR GASALEQSSY GTPESKSRPA GGLAALDSSH CFTNFASNMN ALMNVGAPRH
     FSARLGDFSN SRHYLAELAS CPISSPQISE PQTGSKVPCY PSKQASSLCT SVMNSFSLNH
     LYSREGEV