ID   FOXI3_CANLF             Reviewed;         436 AA.
AC   B5RHS5;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-NOV-2008, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Forkhead box protein I3;
GN   Name=FOXI3;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INVOLVEMENT IN DISEASE.
RX   PubMed=18787161; DOI=10.1126/science.1162525;
RA   Droegemueller C., Karlsson E.K., Hytoenen M.K., Perloski M., Dolf G.,
RA   Sainio K., Lohi H., Lindblad-Toh K., Leeb T.;
RT   "A mutation in hairless dogs implicates FOXI3 in ectodermal development.";
RL   Science 321:1462-1462(2008).
CC   -!- FUNCTION: Possible transcriptional factor. May play a role in the
CC       development of the epithelium of hair and whisker placodes and that of
CC       teeth. {ECO:0000269|PubMed:18787161}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DISEASE: Note=Defects in FOXI3 are the cause of canine ectodermal
CC       dysplasia (CED). CED is an autosomal semi-dominant trait characterized
CC       by missing or abnormally shaped teeth in addition to a hair coat that
CC       is sparse or absent. Heterozygous mutants are found in Mexican and
CC       Peruvian hairless dogs and in Chinese crested dogs. Homozygous mutants
CC       die during embryogenesis.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM998820; CAQ53186.1; -; Genomic_DNA.
DR   RefSeq; NP_001129118.1; NM_001135646.1.
DR   AlphaFoldDB; B5RHS5; -.
DR   SMR; B5RHS5; -.
DR   STRING; 9612.ENSCAFP00000041322; -.
DR   PaxDb; B5RHS5; -.
DR   GeneID; 483075; -.
DR   KEGG; cfa:483075; -.
DR   CTD; 344167; -.
DR   eggNOG; KOG2294; Eukaryota.
DR   InParanoid; B5RHS5; -.
DR   OrthoDB; 1270467at2759; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   4: Predicted;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..436
FT                   /note="Forkhead box protein I3"
FT                   /id="PRO_0000367050"
FT   DNA_BIND        158..252
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          249..319
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          340..410
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        258..277
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        357..410
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   436 AA;  44053 MW;  355E2A0E4CA2F054 CRC64;
     MALYCGDNFG VYSQPGLPPP AAAAAAAAAA PGAPPASRAP YALADYAAPP AAAANPYLWL
     NGPGVGVGVG VGVGGPPAAA AAAAAAYLGA PPPPPPPPGG AAGPFLQPPP AAGTFGCAQR
     AFAQPAPAAP ASPAGPAAPG ELGWLSMASR EDLMKMVRPP YSYSALIAMA IQSAPERKLT
     LSHIYQFVAD SFPFYQRSKA GWQNSIRHNL SLNDCFKKVP RDEDDPGKGN YWTLDPNCEK
     MFDNGNFRRK RKRRSEASSA STSTVAAGTT KSEEGLSSGL GSGVGGKPEG DSPSALLRPP
     QSPEPPEGTK STASSPGGSL LSSAPCLNTF FSSLSTLSVS SSGGAQRAGP GSRHLGIQGT
     PLSSSGAFPA SCISSEAPPD TLQLSNGASS GSGQRSSYYS PFPASTSGGQ SSPFGSPFYN
     FSMVNSLIYP REGSEV