FOXI3_HUMAN
ID FOXI3_HUMAN Reviewed; 420 AA.
AC A8MTJ6; B5RI09;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 3.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Forkhead box protein I3;
GN Name=FOXI3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP IDENTIFICATION.
RX PubMed=18787161; DOI=10.1126/science.1162525;
RA Droegemueller C., Karlsson E.K., Hytoenen M.K., Perloski M., Dolf G.,
RA Sainio K., Lohi H., Lindblad-Toh K., Leeb T.;
RT "A mutation in hairless dogs implicates FOXI3 in ectodermal development.";
RL Science 321:1462-1462(2008).
CC -!- FUNCTION: Possible transcriptional factor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; AC012671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BN001221; CAR63508.1; -; Genomic_DNA.
DR EMBL; BN001222; CAR63509.1; -; mRNA.
DR CCDS; CCDS77433.1; -.
DR RefSeq; NP_001129121.1; NM_001135649.1.
DR AlphaFoldDB; A8MTJ6; -.
DR SMR; A8MTJ6; -.
DR BioGRID; 131290; 2.
DR STRING; 9606.ENSP00000478384; -.
DR iPTMnet; A8MTJ6; -.
DR PhosphoSitePlus; A8MTJ6; -.
DR BioMuta; FOXI3; -.
DR EPD; A8MTJ6; -.
DR MassIVE; A8MTJ6; -.
DR PeptideAtlas; A8MTJ6; -.
DR PRIDE; A8MTJ6; -.
DR ProteomicsDB; 2029; -.
DR Antibodypedia; 73246; 130 antibodies from 22 providers.
DR DNASU; 344167; -.
DR Ensembl; ENST00000428390.3; ENSP00000478384.2; ENSG00000214336.5.
DR GeneID; 344167; -.
DR KEGG; hsa:344167; -.
DR MANE-Select; ENST00000428390.3; ENSP00000478384.2; NM_001135649.3; NP_001129121.1.
DR UCSC; uc032nud.2; human.
DR CTD; 344167; -.
DR DisGeNET; 344167; -.
DR GeneCards; FOXI3; -.
DR HGNC; HGNC:35123; FOXI3.
DR HPA; ENSG00000214336; Group enriched (placenta, retina).
DR MIM; 612351; gene.
DR neXtProt; NX_A8MTJ6; -.
DR OpenTargets; ENSG00000214336; -.
DR PharmGKB; PA164720107; -.
DR VEuPathDB; HostDB:ENSG00000214336; -.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000162575; -.
DR HOGENOM; CLU_046860_0_0_1; -.
DR InParanoid; A8MTJ6; -.
DR OMA; FHNFSMV; -.
DR OrthoDB; 1270467at2759; -.
DR PhylomeDB; A8MTJ6; -.
DR PathwayCommons; A8MTJ6; -.
DR BioGRID-ORCS; 344167; 10 hits in 209 CRISPR screens.
DR GenomeRNAi; 344167; -.
DR Pharos; A8MTJ6; Tbio.
DR PRO; PR:A8MTJ6; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; A8MTJ6; protein.
DR Bgee; ENSG00000214336; Expressed in placenta and 8 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..420
FT /note="Forkhead box protein I3"
FT /id="PRO_0000341225"
FT DNA_BIND 145..239
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 103..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 420 AA; 43326 MW; 4531A9DA62B322E7 CRC64;
MALYCGDNFG VYSQPGLPPP AATAAAPGAP PAARAPYGLA DYAAPPAAAA NPYLWLNGPG
VGGPPSAAAA AAAAYLGAPP PPPPPGAAAG PFLQPPPAAG TFGCSQRPFA QPAPAAPASP
AAPAGPGELG WLSMASREDL MKMVRPPYSY SALIAMAIQS APERKLTLSH IYQFVADSFP
FYQRSKAGWQ NSIRHNLSLN DCFKKVPRDE DDPGKGNYWT LDPNCEKMFD NGNFRRKRKR
RSEASNGSTV AAGTSKSEEG LSSGLGSGVG GKPEEESPST LLRPSHSPEP PEGTKSTASS
PGGPMLTSTP CLNTFFSSLS SLSVSSSVST QRALPGSRHL GIQGAQLPSS GVFSPTSISE
ASADTLQLSN STSNSTGQRS SYYSPFPAST SGGQSSPFSS PFHNFSMVNS LIYPREGSEV
