FOXJ1_RAT
ID FOXJ1_RAT Reviewed; 421 AA.
AC Q63247;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Forkhead box protein J1;
DE AltName: Full=Hepatocyte nuclear factor 3 forkhead homolog 4 {ECO:0000303|PubMed:7753791};
DE Short=HFH-4 {ECO:0000303|PubMed:7753791};
GN Name=Foxj1; Synonyms=Hfh4 {ECO:0000303|PubMed:7753791};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley; TISSUE=Testis;
RX PubMed=7753791; DOI=10.1073/pnas.92.10.4249;
RA Hackett B.P., Brody S.L., Liang M., Zeitz I.D., Bruns L.A., Gitlin J.D.;
RT "Primary structure of hepatocyte nuclear factor/forkhead homologue 4 and
RT characterization of gene expression in the developing respiratory and
RT reproductive epithelium.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:4249-4253(1995).
CC -!- FUNCTION: Transcription factor specifically required for the formation
CC of motile cilia. Acts by activating transcription of genes that mediate
CC assembly of motile cilia, such as CFAP157. Binds the DNA consensus
CC sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G,
CC W is A or T, D is not C, and K is G or T). Activates the transcription
CC of a variety of ciliary proteins in the developing brain and lung.
CC {ECO:0000250|UniProtKB:Q61660}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q61660}.
CC -!- TISSUE SPECIFICITY: Pulmonary epithelium, testis and oviduct.
CC {ECO:0000269|PubMed:7753791}.
CC -!- SIMILARITY: Belongs to the FOXJ1 family. {ECO:0000305}.
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DR EMBL; L36388; AAC37671.1; -; mRNA.
DR RefSeq; NP_446284.1; NM_053832.1.
DR AlphaFoldDB; Q63247; -.
DR SMR; Q63247; -.
DR GeneID; 116557; -.
DR KEGG; rno:116557; -.
DR CTD; 2302; -.
DR RGD; 621764; Foxj1.
DR InParanoid; Q63247; -.
DR OrthoDB; 1270467at2759; -.
DR PhylomeDB; Q63247; -.
DR PRO; PR:Q63247; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISO:RGD.
DR GO; GO:0030036; P:actin cytoskeleton organization; ISO:RGD.
DR GO; GO:0090630; P:activation of GTPase activity; ISO:RGD.
DR GO; GO:0035082; P:axoneme assembly; ISS:UniProtKB.
DR GO; GO:0007420; P:brain development; ISO:RGD.
DR GO; GO:1990314; P:cellular response to insulin-like growth factor stimulus; IEP:RGD.
DR GO; GO:0002508; P:central tolerance induction; ISO:RGD.
DR GO; GO:0032053; P:ciliary basal body organization; ISS:UniProtKB.
DR GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR GO; GO:0007368; P:determination of left/right symmetry; ISS:UniProtKB.
DR GO; GO:0060429; P:epithelium development; ISO:RGD.
DR GO; GO:0035089; P:establishment of apical/basal cell polarity; ISO:RGD.
DR GO; GO:0072016; P:glomerular parietal epithelial cell development; ISO:RGD.
DR GO; GO:0007507; P:heart development; ISO:RGD.
DR GO; GO:0006959; P:humoral immune response; ISO:RGD.
DR GO; GO:0060972; P:left/right pattern formation; ISO:RGD.
DR GO; GO:0050900; P:leukocyte migration; ISO:RGD.
DR GO; GO:0060428; P:lung epithelium development; ISO:RGD.
DR GO; GO:0035502; P:metanephric part of ureteric bud development; ISO:RGD.
DR GO; GO:0044458; P:motile cilium assembly; ISO:RGD.
DR GO; GO:0050869; P:negative regulation of B cell activation; ISO:RGD.
DR GO; GO:0002635; P:negative regulation of germinal center formation; ISO:RGD.
DR GO; GO:0002924; P:negative regulation of humoral immune response mediated by circulating immunoglobulin; ISO:RGD.
DR GO; GO:0032715; P:negative regulation of interleukin-6 production; ISO:RGD.
DR GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISO:RGD.
DR GO; GO:0033085; P:negative regulation of T cell differentiation in thymus; ISO:RGD.
DR GO; GO:0042130; P:negative regulation of T cell proliferation; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0002897; P:positive regulation of central B cell tolerance induction; ISO:RGD.
DR GO; GO:1901248; P:positive regulation of lung ciliated cell differentiation; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR GO; GO:0030856; P:regulation of epithelial cell differentiation; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0032355; P:response to estradiol; IEP:RGD.
DR GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
DR GO; GO:0007283; P:spermatogenesis; IEP:RGD.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW Activator; Cilium biogenesis/degradation; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..421
FT /note="Forkhead box protein J1"
FT /id="PRO_0000091852"
FT DNA_BIND 120..210
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 421 AA; 45566 MW; F5365D33B20926AF CRC64;
MAESWLRLCG AGPGEEAGPE GGMEEPDALD DSLTSLQWLQ EFSILNAKAP TLPPGGTDPL
GYHQVPGLVA PGSPLAADPA CLGQPHTPGK PTSSCTSRSA PPGLQAPPPD DVDYATNPHV
KPPYSYATLI CMAMQASKAT KITLSAIYKW ITDNFCYFRH ADPTWQNSIR HNLSLNKCFI
KVPREKDEPG KGGFWRIDPQ YAERLLSGAF KKRRLPPVHI HPAFARQAAQ EPSTAPWGGP
LTVNREAQQL LQEFEEATGE GGWGTGEGRL GHKRKQPLPK RVAKVLRPPS TLLLTQEEQG
ELEPLKGNFD WEAIFEAGAL GEELSSLEGL ELSPPLSPSS HGEVDLTVHG RHINCPATWG
PPVEQATDSL DFDETFLATS FLQHPWDESS SGCLPPEPLF EAGDATLAAD LQDWASVGAF
L
