ID   FOXJ1_XENTR             Reviewed;         438 AA.
AC   Q5M7N6; Q28JA8;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 2.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Forkhead box protein J1;
DE            Short=FoxJ1;
GN   Name=foxj1 {ECO:0000312|EMBL:AAH88533.1}; ORFNames=TNeu102g20.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:CAJ82756.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula {ECO:0000312|EMBL:CAJ82756.1};
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:CAJ82756.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tail bud {ECO:0000312|EMBL:AAH88533.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Key transcription factor required for motile ciliogenesis.
CC       Activates genes essential for motile cilia formation and function.
CC       {ECO:0000250|UniProtKB:Q708W2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FOXJ1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH88533.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAJ82756.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CR759983; CAJ82756.1; ALT_INIT; mRNA.
DR   EMBL; BC088533; AAH88533.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001011367.1; NM_001011367.1.
DR   AlphaFoldDB; Q5M7N6; -.
DR   SMR; Q5M7N6; -.
DR   PaxDb; Q5M7N6; -.
DR   DNASU; 496834; -.
DR   GeneID; 496834; -.
DR   KEGG; xtr:496834; -.
DR   CTD; 2302; -.
DR   Xenbase; XB-GENE-853648; foxj1.
DR   eggNOG; KOG2294; Eukaryota.
DR   InParanoid; Q5M7N6; -.
DR   OrthoDB; 1270467at2759; -.
DR   Proteomes; UP000008143; Chromosome 10.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0035082; P:axoneme assembly; ISS:UniProtKB.
DR   GO; GO:0032053; P:ciliary basal body organization; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0007368; P:determination of left/right symmetry; ISS:UniProtKB.
DR   GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cilium biogenesis/degradation; DNA-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..438
FT                   /note="Forkhead box protein J1"
FT                   /id="PRO_0000250444"
FT   DNA_BIND        123..217
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT                   ProRule:PRU00089"
FT   CONFLICT        72
FT                   /note="F -> S (in Ref. 1; CAJ82756)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   438 AA;  48947 MW;  829B7E2225B948A8 CRC64;
     MFDLPTVAPI DMEDSWVTFQ AEGEQGQDSF SSSVNLDDSL TSLQWLQEFS ILNANVGKAP
     SSGDSHGYKH LFGAPCSPLA ADPACLGMPH TPGKPISSST SRASHLGLQP MEDIDYKTNP
     HVKPPYSYAT LICMAMQASK KTKITLSAIY KWITDNFCYF RHADPTWQNS IRHNLSLNKC
     FIKVPREKDE PGKGGFWKID PQYADRLMNG AMKKRRLPPV QIHPAFASAQ AAASGNSNRG
     SPWQLSVNSE SHQLLKEFEE ATGEQGWNAL GEHGWNAISD GKSHKRKQPL PKRMFKAPRL
     SSSPMLCQEE QTELGSLKGD FDWEVIFDSS MNGVNFSAFE DLEVTPPLSP VTRSVDLTVH
     GKHIDCPQQW YPLGQDQAVV QNSLDFDETF LATSFLQHPW EENRNDYLSN SANIEQLFDL
     NEEFPAELND WSALGSYI