ID   FOXJ2_XENLA             Reviewed;         512 AA.
AC   Q68EZ2;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Forkhead box protein J2;
DE            Short=FoxJ2;
GN   Name=foxj2 {ECO:0000250|UniProtKB:Q28EM1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAH80056.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye {ECO:0000312|EMBL:AAH80056.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional activator. {ECO:0000250|UniProtKB:Q9P0K8}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
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DR   EMBL; BC080056; AAH80056.1; -; mRNA.
DR   RefSeq; NP_001087521.1; NM_001094052.1.
DR   AlphaFoldDB; Q68EZ2; -.
DR   SMR; Q68EZ2; -.
DR   DNASU; 447345; -.
DR   GeneID; 447345; -.
DR   KEGG; xla:447345; -.
DR   CTD; 447345; -.
DR   Xenbase; XB-GENE-865002; foxj2.S.
DR   OrthoDB; 1270467at2759; -.
DR   Proteomes; UP000186698; Chromosome 7S.
DR   Bgee; 447345; Expressed in muscle tissue and 18 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR045912; FOXJ2/3-like.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR46078; PTHR46078; 2.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..512
FT                   /note="Forkhead box protein J2"
FT                   /id="PRO_0000258006"
FT   DNA_BIND        59..150
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          25..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          143..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          284..326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          448..512
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        143..162
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        163..213
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        284..318
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        448..476
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   512 AA;  56523 MW;  A36B718D1B70EDD2 CRC64;
     MASDLGSSLT SIDWLPQLTI QASIKGSQQN SVGRKGPGSP ADPSAMLSKE EAAAHRDGKP
     PYSYANLIQY AINSAPAKRM TLSEIYRWIC DNFPYYRSAG VGWKNSIRHN LSLNKCFRKV
     PRPRDDPGKG SYWMIDSCPK EDITLPRRKR PHPDDEVSQD SFEQEVNKSP LSSASEVSMP
     QEATQGHPMN NNSPLPTYSQ ANPTQMPPDS RAPTYNNNDC YKFSFSESTF PDLSCSFRSL
     YHSLLGKQGE RGDKDLYNSM QSKQVLPPVH SEVQSSSCCM YQQNSGAAPS NLHPHNVPSI
     SGLPPSHHQA QHQQPPYLPQ QQMPRPPAPG MSLGLPSDWC SNIDSLKESF KIVSSLDWSS
     VDLSQFSDLM ESLRQAELKN WSLDQDHIAS LCDSLSHLLS TTGLLPQNHG QPPSCQAPCM
     PPTTSSACAL RGGKPGHNMA VNSYGQNQPP PVSCGHTFTV SSGYPTQSQA PPTYSQQGRH
     PHRALYPPQR PTLRYPQSSD DIQDDFDWDS IA