FOXJ2_XENTR
ID FOXJ2_XENTR Reviewed; 512 AA.
AC Q28EM1; Q6GL06;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Forkhead box protein J2;
DE AltName: Full=XtFoxJ2;
DE Short=FoxJ2;
GN Name=foxj2 {ECO:0000312|EMBL:CAJ83450.1}; ORFNames=TGas040m18.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000312|EMBL:CAJ83450.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastrula {ECO:0000312|EMBL:CAJ83450.1};
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|EMBL:CAJ83450.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tail bud {ECO:0000312|EMBL:AAH74713.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=16461016; DOI=10.1016/j.modgep.2005.11.007;
RA Choi V.M., Harland R.M., Khokha M.K.;
RT "Developmental expression of FoxJ1.2, FoxJ2, and FoxQ1 in Xenopus
RT tropicalis.";
RL Gene Expr. Patterns 6:443-447(2006).
CC -!- FUNCTION: Transcriptional activator. {ECO:0000250|UniProtKB:Q9P0K8}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed broadly prior to stage 23, after which
CC expression becomes restricted to dorsal tissues. By stage 28,
CC restricted to the notochord and floorplate. Expressed almost
CC exclusively in the most ventral part of the neural tube in anterior
CC regions of the embryo. In posterior regions, expressed more dorsally in
CC the neural tube. At stage 35, expression remains in the notochord,
CC neural tube and brain. {ECO:0000269|PubMed:16461016}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH74713.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CR848176; CAJ83450.1; -; mRNA.
DR EMBL; BC074713; AAH74713.1; ALT_INIT; mRNA.
DR RefSeq; NP_001005675.2; NM_001005675.2.
DR AlphaFoldDB; Q28EM1; -.
DR SMR; Q28EM1; -.
DR PaxDb; Q28EM1; -.
DR DNASU; 448174; -.
DR GeneID; 448174; -.
DR KEGG; xtr:448174; -.
DR CTD; 55810; -.
DR Xenbase; XB-GENE-483646; foxj2.
DR eggNOG; KOG2294; Eukaryota.
DR HOGENOM; CLU_034661_0_0_1; -.
DR InParanoid; Q28EM1; -.
DR OMA; PVHSEVQ; -.
DR OrthoDB; 1270467at2759; -.
DR TreeFam; TF333250; -.
DR Proteomes; UP000008143; Chromosome 7.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000027639; Expressed in skeletal muscle tissue and 15 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR045912; FOXJ2/3-like.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46078; PTHR46078; 2.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..512
FT /note="Forkhead box protein J2"
FT /id="PRO_0000258007"
FT DNA_BIND 59..150
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 25..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 144..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..312
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 512 AA; 56531 MW; 58EDF1A0EF5AA78A CRC64;
MASDLGSSLT SIDWLPQLTI QAAMKGSQQN NAGRKGPGSP TDPSAMLSKE EAAAHRDGKP
PYSYANLIQY AINSAPAKRM TLSEIYRWIC DNFPYYRNAG VGWKNSIRHN LSLNKCFRKV
PRPRDDPGKG SYWMIDSCPK EDVALPRRKR PHPDDEVSQD SFEQDVNKSP LRSASEVSMP
QEGTQGHPMN NNSPLPSYSQ ANPTQMPPDS RAPTYNNNDC YKFSFSESTF PDLGCSFRSL
YHSLLGKQGE RGDKDLYNSM QSKQVLPPVH SEVQSSSCCM YQQNSGAAPS NLHPHNVPSI
SGPPPPHHQA QHQQPPYLPQ QQMPRPPAPG MSLGLPSDWC SNIDSLKESF KIVSSLDWSS
VDLSQFSDLM ESLRQAELKN WSLDQDHIAS LCDSLSHLLS TTGLLPPTHG QPPSCQAPCM
PPTTSSACAL RGGKPVHNMT VNSYGQNQPP PVSCGHTFTA SSGYPIQSQA PPTYSQQGRH
PQRALYPPQR PTLRYPQSSD DIQDDFDWDS IA
