ID   FOXL3_HUMAN             Reviewed;         233 AA.
AC   A0A1W2PRP0;
DT   17-JUN-2020, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2017, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Forkhead box protein L3 {ECO:0000305};
GN   Name=FOXL3 {ECO:0000312|HGNC:HGNC:54201};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
CC   -!- FUNCTION: Probable transcriptional regulator.
CC       {ECO:0000250|UniProtKB:Q12952}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
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DR   EMBL; AC187653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_011513358.1; XM_011515056.1.
DR   AlphaFoldDB; A0A1W2PRP0; -.
DR   SMR; A0A1W2PRP0; -.
DR   BioMuta; ENSG00000248767; -.
DR   MassIVE; A0A1W2PRP0; -.
DR   PeptideAtlas; A0A1W2PRP0; -.
DR   Ensembl; ENST00000506382.2; ENSP00000492766.1; ENSG00000248767.2.
DR   MANE-Select; ENST00000506382.2; ENSP00000492766.1; NM_001374838.1; NP_001361767.1.
DR   GeneCards; FOXL3; -.
DR   HGNC; HGNC:54201; FOXL3.
DR   HPA; ENSG00000248767; Tissue enriched (testis).
DR   neXtProt; NX_A0A1W2PRP0; -.
DR   VEuPathDB; HostDB:ENSG00000248767; -.
DR   GeneTree; ENSGT00940000162800; -.
DR   OMA; CRPAYSY; -.
DR   SignaLink; A0A1W2PRP0; -.
DR   GenomeRNAi; 100288524; -.
DR   PRO; PR:A0A1W2PRP0; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; A0A1W2PRP0; protein.
DR   Bgee; ENSG00000248767; Expressed in right testis and 29 other tissues.
DR   ExpressionAtlas; A0A1W2PRP0; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Nucleus; Reference proteome; Transcription.
FT   CHAIN           1..233
FT                   /note="Forkhead box protein L3"
FT                   /id="PRO_0000450370"
FT   DNA_BIND        32..130
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          125..198
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   233 AA;  25969 MW;  614D84FBD16F22E9 CRC64;
     MFDSSQYPYN CFNYDADDYP AGSSDEDKRL TRPAYSYIAL IAMAIQQSPA GRVTLSGIYD
     FIMRKFPYYR ANQRAWQNSI RHNLSLNSCF VKVPRSEGHE KGKGNYWTFA GGCESLLDLF
     ENGNYRRRRR RRGPKREGPR GPRAGGAQGP SGPSEPPAAQ GRLAPDSAGE GAPGREPPAS
     PAPPGKEHPR DLKFSIDYIL SSPDPFPGLK PPCLAQEGRY PRLENVGLHF WTM