FOXN2_HUMAN
ID FOXN2_HUMAN Reviewed; 431 AA.
AC P32314; Q15769; Q6P4Q2;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 3.
DT 03-AUG-2022, entry version 181.
DE RecName: Full=Forkhead box protein N2;
DE AltName: Full=Human T-cell leukemia virus enhancer factor;
GN Name=FOXN2; Synonyms=HTLF;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=1639393; DOI=10.1016/0888-7543(92)90138-i;
RA Li C., Lusis A.J., Sparkes R., Tran S.-M., Gaynor R.B.;
RT "Characterization and chromosomal mapping of the gene encoding the cellular
RT DNA binding protein HTLF.";
RL Genomics 13:658-664(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Binds to the purine-rich region in HTLV-I LTR.
CC -!- INTERACTION:
CC P32314; Q9UKB1: FBXW11; NbExp=4; IntAct=EBI-10706164, EBI-355189;
CC P32314; P22670: RFX1; NbExp=3; IntAct=EBI-10706164, EBI-716037;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P32314-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P32314-2; Sequence=VSP_035743, VSP_035744;
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DR EMBL; U57029; AAB03504.1; -; mRNA.
DR EMBL; AC091485; AAY14813.1; -; Genomic_DNA.
DR EMBL; BC063305; AAH63305.1; -; mRNA.
DR CCDS; CCDS1838.1; -. [P32314-1]
DR RefSeq; NP_002149.2; NM_002158.3. [P32314-1]
DR RefSeq; XP_005264339.1; XM_005264282.2.
DR RefSeq; XP_005264340.1; XM_005264283.2. [P32314-1]
DR RefSeq; XP_006712064.1; XM_006712001.3.
DR RefSeq; XP_006712065.1; XM_006712002.3.
DR RefSeq; XP_011531110.1; XM_011532808.2.
DR RefSeq; XP_016859445.1; XM_017003956.1.
DR RefSeq; XP_016859446.1; XM_017003957.1.
DR RefSeq; XP_016859447.1; XM_017003958.1.
DR RefSeq; XP_016859448.1; XM_017003959.1.
DR AlphaFoldDB; P32314; -.
DR SMR; P32314; -.
DR BioGRID; 109576; 18.
DR IntAct; P32314; 8.
DR MINT; P32314; -.
DR STRING; 9606.ENSP00000343633; -.
DR iPTMnet; P32314; -.
DR PhosphoSitePlus; P32314; -.
DR BioMuta; FOXN2; -.
DR DMDM; 215274148; -.
DR EPD; P32314; -.
DR jPOST; P32314; -.
DR MassIVE; P32314; -.
DR MaxQB; P32314; -.
DR PaxDb; P32314; -.
DR PeptideAtlas; P32314; -.
DR PRIDE; P32314; -.
DR ProteomicsDB; 54867; -. [P32314-1]
DR ProteomicsDB; 54868; -. [P32314-2]
DR Antibodypedia; 932; 300 antibodies from 27 providers.
DR DNASU; 3344; -.
DR Ensembl; ENST00000340553.8; ENSP00000343633.3; ENSG00000170802.17. [P32314-1]
DR GeneID; 3344; -.
DR KEGG; hsa:3344; -.
DR MANE-Select; ENST00000340553.8; ENSP00000343633.3; NM_002158.4; NP_002149.2.
DR UCSC; uc002rwh.2; human. [P32314-1]
DR CTD; 3344; -.
DR DisGeNET; 3344; -.
DR GeneCards; FOXN2; -.
DR HGNC; HGNC:5281; FOXN2.
DR HPA; ENSG00000170802; Tissue enhanced (bone marrow, brain).
DR MIM; 143089; gene.
DR neXtProt; NX_P32314; -.
DR OpenTargets; ENSG00000170802; -.
DR PharmGKB; PA162388822; -.
DR VEuPathDB; HostDB:ENSG00000170802; -.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000159118; -.
DR HOGENOM; CLU_032050_1_0_1; -.
DR InParanoid; P32314; -.
DR OMA; DPCNSDG; -.
DR OrthoDB; 699973at2759; -.
DR PhylomeDB; P32314; -.
DR TreeFam; TF105083; -.
DR PathwayCommons; P32314; -.
DR SignaLink; P32314; -.
DR BioGRID-ORCS; 3344; 14 hits in 1101 CRISPR screens.
DR ChiTaRS; FOXN2; human.
DR GenomeRNAi; 3344; -.
DR Pharos; P32314; Tbio.
DR PRO; PR:P32314; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; P32314; protein.
DR Bgee; ENSG00000170802; Expressed in endothelial cell and 187 other tissues.
DR ExpressionAtlas; P32314; baseline and differential.
DR Genevisible; P32314; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0035914; P:skeletal muscle cell differentiation; IEA:Ensembl.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..431
FT /note="Forkhead box protein N2"
FT /id="PRO_0000091868"
FT DNA_BIND 112..208
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 364..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..90
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:1639393"
FT /id="VSP_035743"
FT VAR_SEQ 91..105
FT /note="DDVPSFGPACYQNPE -> MMCDPLDQLATRTQK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:1639393"
FT /id="VSP_035744"
SQ SEQUENCE 431 AA; 47161 MW; 5F71D3C0E4BA1797 CRC64;
MGPVIGMTPD KRAETPGAEK IAGLSQIYKM GSLPEAVDAA RPKATLVDSE SADDELTNLN
WLHESTNLLT NFSLGSEGLP IVSPLYDIEG DDVPSFGPAC YQNPEKKSAT SKPPYSFSLL
IYMAIEHSPN KCLPVKEIYS WILDHFPYFA TAPTGWKNSV RHNLSLNKCF QKVERSHGKV
NGKGSLWCVD PEYKPNLIQA LKKQPFSSAS SQNGSLSPHY LSSVIKQNQV RNLKESDIDA
AAAMMLLNTS IEQGILECEK PLPLKTALQK KRSYGNAFHH PSAVRLQESD SLATSIDPKE
DHNYSASSMA AQRCASRSSV SSLSSVDEVY EFIPKNSHVG SDGSEGFHSE EDTDVDYEDD
PLGDSGYASQ PCAKISEKGQ SGKKMRKQTC QEIDEELKEA AGSLLHLAGI RTCLGSLIST
AKTQNQKQRK K
