ID   FOXN2_XENLA             Reviewed;         430 AA.
AC   Q66J77;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Forkhead box protein N2;
GN   Name=foxn2 {ECO:0000303|PubMed:16525939};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAH81030.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAH81030.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=16525939; DOI=10.1387/ijdb.052126ms;
RA   Schuff M., Roessner A., Donow C., Knoechel W.;
RT   "Temporal and spatial expression patterns of FoxN genes in Xenopus laevis
RT   embryos.";
RL   Int. J. Dev. Biol. 50:429-434(2006).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in the developing eye from stage 23.
CC       Localized to the prospective retinal layer and a layer of cells lateral
CC       to the ventricular zone. At stage 29, expression extends to the
CC       branchial arches and the brain. At stage 33/34, expressed in the vagal
CC       ganglion. At stage 36, expression in the retina decreases. Not
CC       expressed in the eye lens. {ECO:0000269|PubMed:16525939}.
CC   -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically. Present
CC       in all embryonic stages including early cleavage stages, with levels
CC       decreasing slightly during gastrulation and neurulation (stages 10-20).
CC       Levels then increase at stage 30 and expression persists until stage
CC       45. {ECO:0000269|PubMed:16525939}.
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DR   EMBL; BC081030; AAH81030.1; -; mRNA.
DR   RefSeq; NP_001087640.1; NM_001094171.1.
DR   AlphaFoldDB; Q66J77; -.
DR   SMR; Q66J77; -.
DR   PRIDE; Q66J77; -.
DR   DNASU; 447464; -.
DR   GeneID; 447464; -.
DR   KEGG; xla:447464; -.
DR   CTD; 447464; -.
DR   Xenbase; XB-GENE-952923; foxn2.S.
DR   Proteomes; UP000186698; Chromosome 5S.
DR   Bgee; 447464; Expressed in blastula and 18 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..430
FT                   /note="Forkhead box protein N2"
FT                   /id="PRO_0000247732"
FT   DNA_BIND        108..204
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          1..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          299..326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          338..391
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        311..326
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   430 AA;  47096 MW;  1E666D3359647DDE CRC64;
     MGPATGMTPD KNIESPTAEK VPGLSQTENM GSLPEEVGAA RPKASMVDNG ATDEELTNLN
     WLHESTNLLN NFSLGSEGVS AGSPLYDIEG DLSPSGCQTP EKLSASSKPP YSFSLLIYMA
     IEHSPNKCLP VKDIYSWILD RFPYFSTAPT GWKNSVRHNL SLNKYFQKVE RSHGKVNGKG
     SLWCVDPEYK PSLIQALKKQ PFSSALALYT PPTSPTSVSS RPYVLTSASR RKQIHYVKDS
     DIDAATAMML LNSSIKEEAL DRQKPQPLKV VLPKKRSYAS AFKHCPPLSL QENDGEVINI
     DPKEDHNYSA SGGDSQRCES RSSVSSLSSV EEVYEFIPKN SRTGSDGSEG FHSEDDTDID
     YEEDTLGDNG YVPQPSGNDL HGSKLRKEAS QDIDEELKEA AGSLLHLAGI RTCLDSLLKT
     AKAQSHKHRK