ID   FOXN2_XENTR             Reviewed;         334 AA.
AC   Q28F43;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Forkhead box protein N2;
GN   Name=foxn2 {ECO:0000250|UniProtKB:Q66J77}; ORFNames=TGas051c08.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:CAJ83519.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; CR762174; CAJ83519.1; -; mRNA.
DR   RefSeq; NP_001017017.1; NM_001017017.2.
DR   AlphaFoldDB; Q28F43; -.
DR   SMR; Q28F43; -.
DR   PaxDb; Q28F43; -.
DR   GeneID; 549771; -.
DR   KEGG; xtr:549771; -.
DR   CTD; 3344; -.
DR   Xenbase; XB-GENE-952918; foxn2.
DR   eggNOG; KOG2294; Eukaryota.
DR   InParanoid; Q28F43; -.
DR   OrthoDB; 699973at2759; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..334
FT                   /note="Forkhead box protein N2"
FT                   /id="PRO_0000247733"
FT   DNA_BIND        108..204
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          1..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          83..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   334 AA;  36380 MW;  BF27E7481D9D5EC5 CRC64;
     MGPVTGMTPD KNIETPAAEK VPGLSQTENM GSLPEEVGAA RPKASMVDSG TTDEELTNLN
     WLHESTNLLN NFSLGSEGVP TGSPLYDIEG DLSPSGCQTP EKLSASSKPP YSFSLLIYMA
     IEHSPNKCLP VKDIYSWILD RFPYFATAPT GWKNSVRHNL SLNKYFQKVE RSHGKVNGKG
     SLWCVDPEYK PSLIQALKKQ PFSSALALYT PPTSPTSVSS RSSVSSLSSV EEVYEFIPKN
     SRAGSDGSEG FHSEDDTDID YEEDMLGDSG YVSQPCINPS SNDLHGNKLR KEACQDIDDE
     LKEAAGSLLH LAGIRTCLDS LLKTAKAQSQ KHRK