FOXN3_MOUSE
ID FOXN3_MOUSE Reviewed; 457 AA.
AC Q499D0; Q8C5N8; Q9CU83;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Forkhead box protein N3;
DE AltName: Full=Checkpoint suppressor 1;
GN Name=Foxn3; Synonyms=Ches1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAH99971.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=129/Sv X 129SvCp {ECO:0000312|EMBL:AAH99971.1};
RC TISSUE=Embryonic stem cell {ECO:0000312|EMBL:AAH99971.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2] {ECO:0000312|EMBL:BAB30701.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 46-457.
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAB30701.1};
RC TISSUE=Embryonic testis {ECO:0000312|EMBL:BAC37064.1}, and
RC Head {ECO:0000312|EMBL:BAB30701.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-97 AND SER-415, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Acts as a transcriptional repressor. May be involved in DNA
CC damage-inducible cell cycle arrests (checkpoints) (By similarity).
CC {ECO:0000250|UniProtKB:O00409}.
CC -!- SUBUNIT: Interacts through its C-terminus with the C-terminus of
CC SNW1/SKIP. {ECO:0000250|UniProtKB:O00409}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC099971; AAH99971.1; -; mRNA.
DR EMBL; AK017346; BAB30701.1; -; mRNA.
DR EMBL; AK077921; BAC37064.1; -; mRNA.
DR CCDS; CCDS26103.1; -.
DR RefSeq; NP_899009.2; NM_183186.2.
DR RefSeq; XP_006516302.1; XM_006516239.3.
DR RefSeq; XP_006516303.1; XM_006516240.2.
DR AlphaFoldDB; Q499D0; -.
DR SMR; Q499D0; -.
DR STRING; 10090.ENSMUSP00000036035; -.
DR iPTMnet; Q499D0; -.
DR PhosphoSitePlus; Q499D0; -.
DR EPD; Q499D0; -.
DR MaxQB; Q499D0; -.
DR PaxDb; Q499D0; -.
DR PeptideAtlas; Q499D0; -.
DR PRIDE; Q499D0; -.
DR ProteomicsDB; 267401; -.
DR Antibodypedia; 13438; 146 antibodies from 24 providers.
DR DNASU; 71375; -.
DR Ensembl; ENSMUST00000046859; ENSMUSP00000036035; ENSMUSG00000033713.
DR Ensembl; ENSMUST00000085108; ENSMUSP00000082189; ENSMUSG00000033713.
DR Ensembl; ENSMUST00000177451; ENSMUSP00000135082; ENSMUSG00000033713.
DR GeneID; 71375; -.
DR KEGG; mmu:71375; -.
DR UCSC; uc007ors.1; mouse.
DR CTD; 1112; -.
DR MGI; MGI:1918625; Foxn3.
DR VEuPathDB; HostDB:ENSMUSG00000033713; -.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000155937; -.
DR HOGENOM; CLU_032050_1_0_1; -.
DR InParanoid; Q499D0; -.
DR OMA; XSIGKGS; -.
DR OrthoDB; 699973at2759; -.
DR PhylomeDB; Q499D0; -.
DR TreeFam; TF105083; -.
DR BioGRID-ORCS; 71375; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Foxn3; mouse.
DR PRO; PR:Q499D0; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q499D0; protein.
DR Bgee; ENSMUSG00000033713; Expressed in animal zygote and 233 other tissues.
DR ExpressionAtlas; Q499D0; baseline and differential.
DR Genevisible; Q499D0; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0008022; F:protein C-terminus binding; ISO:MGI.
DR GO; GO:0097094; P:craniofacial suture morphogenesis; IMP:MGI.
DR GO; GO:0007095; P:mitotic G2 DNA damage checkpoint signaling; ISO:MGI.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 1: Evidence at protein level;
KW Cell cycle; DNA-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Repressor; Transcription; Transcription regulation.
FT CHAIN 1..457
FT /note="Forkhead box protein N3"
FT /id="PRO_0000245102"
FT DNA_BIND 114..210
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 86..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..373
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..422
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 83
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 85
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O00409"
FT MOD_RES 97
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 415
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 457 AA; 50345 MW; 52B473A3954C42B0 CRC64;
MGPVMPASKK AESSGISVSS GLSQRYRGSG FSKALQEDDD LDFPLPDIRL EEGAMEDEEL
TNLNWLHESK NLLKSFGESV LRSVSPVQDL DDDTPPSPAH SDMPYDARQN PNCKPPYSFS
CLIFMAIEDS PTKRLPVKDI YNWILEHFPY FANAPTGWKN SVRHNLSLNK CFKKVDKERS
QSIGKGSLWC IDPEYRQNLI QALKKTPYHP PPTPQAYQST SGPPIWPGST FFKRNGALLQ
VSPGVIQNGA RVLSRGLFPG VRPLPITPIG MTAAIRNSIT SCRMRTESEP PCGSPVVSGD
PKEDHNYSSA KSSTARSTSP TSDSISSSSS SADDHYEFAT KGSQEGSEGS FQSHESHSEP
EEEDRKPSPK EGKDALGDSG YASQHKKRQH FAKARKVPSD TLPLKKRRTE KPPESDDEEM
KEAAGSLLHL AGIRSCLNNI TNRTAKGQKE QKETAKN
