ID   FOXN3_PIG               Reviewed;         485 AA.
AC   Q33BP8;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Forkhead box protein N3;
DE   AltName: Full=Checkpoint suppressor 1;
GN   Name=FOXN3; Synonyms=CHES1;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1] {ECO:0000312|EMBL:BAE48220.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Skeletal muscle {ECO:0000312|EMBL:BAE48220.1};
RX   PubMed=16573525; DOI=10.1111/j.1365-2052.2005.01397.x;
RA   Sato S., Hasebe H., Sato S., Asahi Y., Hayashi T., Kobayashi E.,
RA   Sugimoto Y.;
RT   "High-resolution physical mapping and construction of a porcine contig
RT   spanning the intramuscular fat content QTL.";
RL   Anim. Genet. 37:113-120(2006).
CC   -!- FUNCTION: Acts as a transcriptional repressor. May be involved in DNA
CC       damage-inducible cell cycle arrests (checkpoints) (By similarity).
CC       {ECO:0000250|UniProtKB:O00409}.
CC   -!- SUBUNIT: Interacts through its C-terminus with the C-terminus of
CC       SNW1/SKIP. {ECO:0000250|UniProtKB:O00409}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; AB240453; BAE48220.1; -; mRNA.
DR   RefSeq; NP_001038001.1; NM_001044536.1.
DR   AlphaFoldDB; Q33BP8; -.
DR   SMR; Q33BP8; -.
DR   STRING; 9823.ENSSSCP00000002629; -.
DR   PaxDb; Q33BP8; -.
DR   PRIDE; Q33BP8; -.
DR   GeneID; 733584; -.
DR   KEGG; ssc:733584; -.
DR   CTD; 1112; -.
DR   eggNOG; KOG2294; Eukaryota.
DR   InParanoid; Q33BP8; -.
DR   OrthoDB; 699973at2759; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; DNA-binding; Nucleus; Phosphoprotein; Reference proteome;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..485
FT                   /note="Forkhead box protein N3"
FT                   /id="PRO_0000245103"
FT   DNA_BIND        114..210
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          86..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          315..454
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        341..363
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        380..401
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        427..452
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         83
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q499D0"
FT   MOD_RES         85
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O00409"
FT   MOD_RES         97
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q499D0"
FT   MOD_RES         443
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q499D0"
SQ   SEQUENCE   485 AA;  53307 MW;  463AAD1990B4DF65 CRC64;
     MGPVMPPSKK PESPGISVSS GLSQCYRGSS FSKALQEDDD LDFSLPDIRL EEGAMEDEEL
     TNLNWLHESK NLLKSFGDSV LRSVSPVQDL DDDTPPSPAH SDMPYDARQN PNCKPPYSFS
     CLIFMAIEDS PTKRLPVKDI YNWILEHFPY FANAPTGWKN SVRHNLSLNK CFKKVDKERS
     QSIGKGSLWC IDPEYRQNLI QALKKTPYHS HSNVFNTPPA SPQAYQSTSG PPIWPGSTFF
     KRNGALLQDP DIDAASAMML LNTPPEIQAG FPPGVIQNGA RVLSRGLFPG VRPLPITPIG
     MTAAVRNGLT SCRMRTESEP SCGSPVVSGD PKEDHNYSSA KSSHARSTSP ASDCVSSSSA
     DDHYEFATKG GQEGSEGSFQ SHESHSETEE DDRKCSPKEA KDALGDSGYA SQHKKRQHFA
     KARKVPSDTL PLKKRRTEKP PESDDEEMKE AAGSLLHLAG IRSCLNNITN RTAKGQKEQK
     ETTKN