ID   FOXN3_XENTR             Reviewed;         464 AA.
AC   Q28G71;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Forkhead box protein N3;
GN   Name=foxn3 {ECO:0000250|UniProtKB:Q3BJS3}; ORFNames=TGas136a14.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:CAJ83827.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a transcriptional repressor. May be involved in DNA
CC       damage-inducible cell cycle arrests (checkpoints) (By similarity).
CC       {ECO:0000250|UniProtKB:O00409}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; CR761524; CAJ83827.1; -; mRNA.
DR   RefSeq; XP_012823843.1; XM_012968389.2.
DR   RefSeq; XP_012823844.1; XM_012968390.2.
DR   AlphaFoldDB; Q28G71; -.
DR   SMR; Q28G71; -.
DR   STRING; 8364.ENSXETP00000036315; -.
DR   PaxDb; Q28G71; -.
DR   DNASU; 549054; -.
DR   Ensembl; ENSXETT00000036316; ENSXETP00000036316; ENSXETG00000016645.
DR   GeneID; 549054; -.
DR   CTD; 1112; -.
DR   Xenbase; XB-GENE-483117; foxn3.
DR   eggNOG; KOG2294; Eukaryota.
DR   InParanoid; Q28G71; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000016645; Expressed in 2-cell stage embryo and 13 other tissues.
DR   ExpressionAtlas; Q28G71; differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; DNA-binding; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..464
FT                   /note="Forkhead box protein N3"
FT                   /id="PRO_0000247735"
FT   DNA_BIND        113..209
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          1..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          85..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          294..337
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          381..428
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..29
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..53
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        319..337
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        404..428
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   464 AA;  51645 MW;  702994B1AC5F62C5 CRC64;
     MGPIMPPSKK PESTGISVSS QCYRSSTLSN PLHDDDDLDF PPPAVKINKE KGGMEDEELT
     NLNWLHESKN LLKSFGDTVL RSVSPVQDID DDTPPSPAQS DMPYDAKQNP NCKPPYSFSC
     LIFMAIEDSP TKRLPVKDIY NWILEHFPYF ANAPTGWKNS VRHNLSLNKC FKKVDKDRSQ
     SIGKGSLWCI DPEYRQNLIQ ALKKTPYHPY SHVFNTPPTS PQAYQSTSVP PLWPGSTFFK
     KNGALLQVPP GVIQNGARVL NRGIFSGVRP LPINPIGAMA ASVRNGIANC RTRMESEPSC
     GSPLVSSDPK DDHNYSSAKS ANKRSSSPSD SISSSSADDH YEFAAKVCRE GSDISFQSHE
     SFSETEEEDK KQIKKELKDS LVESGYSSQH KKKQHLLKLR RIPSDALPLK KRRTEKPPES
     DDEEMKEAAG SLLHLAGIRS CLNNITNRTA KGQKEQKDKE TTKN