ID   FOXN5_XENLA             Reviewed;         295 AA.
AC   Q3BJS0;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Forkhead box protein N5;
GN   Name=foxn5 {ECO:0000312|EMBL:CAJ38822.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:CAJ38822.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Gastrula {ECO:0000269|PubMed:16525939};
RX   PubMed=16525939; DOI=10.1387/ijdb.052126ms;
RA   Schuff M., Roessner A., Donow C., Knoechel W.;
RT   "Temporal and spatial expression patterns of FoxN genes in Xenopus laevis
RT   embryos.";
RL   Int. J. Dev. Biol. 50:429-434(2006).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Ubiquitously expressed in early cleavage stage and
CC       gastrula stage embryos. {ECO:0000269|PubMed:16525939}.
CC   -!- DEVELOPMENTAL STAGE: Expressed maternally. Expression levels decrease
CC       from gastrulation until the onset of neurulation (stage 15), when
CC       expression is absent. {ECO:0000269|PubMed:16525939}.
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DR   EMBL; AM114797; CAJ38822.1; -; mRNA.
DR   RefSeq; NP_001089122.1; NM_001095653.1.
DR   AlphaFoldDB; Q3BJS0; -.
DR   SMR; Q3BJS0; -.
DR   GeneID; 733406; -.
DR   KEGG; xla:733406; -.
DR   CTD; 733406; -.
DR   Xenbase; XB-GENE-865022; foxr1.L.
DR   OrthoDB; 912825at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 733406; Expressed in ovary and 6 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..295
FT                   /note="Forkhead box protein N5"
FT                   /id="PRO_0000247737"
FT   DNA_BIND        178..275
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          119..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        120..141
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   295 AA;  34383 MW;  302E2B6CA26E7295 CRC64;
     MYLRFANRKP YEKLHLSTAL EDWDMSEELK LSITADQYFA GADDKVERYT LRRQHSTELS
     PTRSEEGDFQ ECKFRPSLWL VVDPNLVIPC PEWINRIPPA PELTSPPLQL QRQLSVEYST
     VEDSEDEAPT SCSDLMTDDD NDDSYNPCQP KNKHKRAKCL GKKMRVQKGL TELESWARPP
     LNYCNLISLA LRNSEDGCLN VQQIYSFVRD HFPFFRIAPD GWKNTVRHNL CFSSSFEKSS
     GWVCADGHRR SCLWKLTRQG RRKFRNEMHA LSDDLLHVLR RSMKKPALME LMFGM